Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study
Background: Glioblastomas are aggressive brain tumours that significantly impact patients’ functional and psychological well-being, making the evaluation of health-related quality of life (HRQoL) essential. Aim: This study aims to assess the quality of life (QoL) and neurocognitive status of gliobl...
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| Format: | Article |
| Language: | English |
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AOSIS
2025-01-01
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| Series: | Journal of Public Health in Africa |
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| Online Access: | https://publichealthinafrica.org/index.php/jphia/article/view/660 |
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| author | Mohamed A Baba Ahmed Kharbach Mohamed Lmejjati Nawal Adali |
| author_facet | Mohamed A Baba Ahmed Kharbach Mohamed Lmejjati Nawal Adali |
| author_sort | Mohamed A Baba |
| collection | DOAJ |
| description | Background: Glioblastomas are aggressive brain tumours that significantly impact patients’ functional and psychological well-being, making the evaluation of health-related quality of life (HRQoL) essential.
Aim: This study aims to assess the quality of life (QoL) and neurocognitive status of glioblastoma patients in Morocco.
Setting: Patients were recruited from two renowned oncology centres in Morocco.
Methods: Patients receiving care at two renowned oncology centres were enrolled between April 2021 and January 2024. The QLQ-C30 and QLQ-BN20 scales were used to assess QoL, while neurocognitive function was evaluated using the Mini-Mental State Examination (MMSE) test. Data normality were checked using the Shapiro-Wilk test, and non-parametric methods were used to compare scores. Variables such as age, tumour laterality, residence, and educational status were examined for their association with overall QoL. Both univariate linear regression and multivariate regression analyses were conducted. Statistical analyses were performed using the JAMOVI software.
Results: The study enrolled 106 patients, with a median age of 56.7 years. Among them, 66% were male, while 34% were female. Multiple linear regression showed that age (B: –15.46; 95% CI: –24.15 to –6.77; p 0.001), education level (B: –9.36; 95% CI: 0.84 to 17.88; p = 0.032), distance from hospital (B: –9.85; 95% CI: –18.34 to –1.36; p = 0.023), and tumour laterality (B= –12.36; 95% CI: –20.65 to –4.06; p = 0.004) were significantly associated with overall QoL at 3 months follow-up.
Conclusion: The results indicate a decline in HRQoL during follow-up among glioblastoma patients. Advancing age, tumour location on the left side, education level, and proximity to the hospital significantly influence the overall QoL.
Contribution: This study highlights the critical factors impacting HRQoL in glioblastoma patients in Morocco, providing insights for improving patient care. |
| format | Article |
| id | doaj-art-41a445864319433e94f94207a5db6517 |
| institution | Kabale University |
| issn | 2038-9922 2038-9930 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Journal of Public Health in Africa |
| spelling | doaj-art-41a445864319433e94f94207a5db65172025-02-11T13:24:50ZengAOSISJournal of Public Health in Africa2038-99222038-99302025-01-01161e1e710.4102/jphia.v16i1.660778Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective studyMohamed A Baba0Ahmed Kharbach1Mohamed Lmejjati2Nawal Adali3Department of Public Health, Faculty of Medicine and Pharmacy of Agadir, Ibn Zohr University, Agadir, Morocco; and Laboratory of Cell Biology and Molecular Genetics, Department of Biology, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco; and High Institute of Nursing Professions and Technical Health, AgadirLaboratory of Cell Biology and Molecular Genetics, Department of Biology, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco; and Department of Public Health, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University, RabatDepartment of Neurosurgery, Faculty of Medicine and Pharmacy of Agadir, Ibn Zohr University, AgadirDepartment of Neurology, Faculty of Medicine and Pharmacy of Agadir, Ibn Zohr University, AgadirBackground: Glioblastomas are aggressive brain tumours that significantly impact patients’ functional and psychological well-being, making the evaluation of health-related quality of life (HRQoL) essential. Aim: This study aims to assess the quality of life (QoL) and neurocognitive status of glioblastoma patients in Morocco. Setting: Patients were recruited from two renowned oncology centres in Morocco. Methods: Patients receiving care at two renowned oncology centres were enrolled between April 2021 and January 2024. The QLQ-C30 and QLQ-BN20 scales were used to assess QoL, while neurocognitive function was evaluated using the Mini-Mental State Examination (MMSE) test. Data normality were checked using the Shapiro-Wilk test, and non-parametric methods were used to compare scores. Variables such as age, tumour laterality, residence, and educational status were examined for their association with overall QoL. Both univariate linear regression and multivariate regression analyses were conducted. Statistical analyses were performed using the JAMOVI software. Results: The study enrolled 106 patients, with a median age of 56.7 years. Among them, 66% were male, while 34% were female. Multiple linear regression showed that age (B: –15.46; 95% CI: –24.15 to –6.77; p 0.001), education level (B: –9.36; 95% CI: 0.84 to 17.88; p = 0.032), distance from hospital (B: –9.85; 95% CI: –18.34 to –1.36; p = 0.023), and tumour laterality (B= –12.36; 95% CI: –20.65 to –4.06; p = 0.004) were significantly associated with overall QoL at 3 months follow-up. Conclusion: The results indicate a decline in HRQoL during follow-up among glioblastoma patients. Advancing age, tumour location on the left side, education level, and proximity to the hospital significantly influence the overall QoL. Contribution: This study highlights the critical factors impacting HRQoL in glioblastoma patients in Morocco, providing insights for improving patient care.https://publichealthinafrica.org/index.php/jphia/article/view/660cancerglioblastomabrainquality of lifemorocco |
| spellingShingle | Mohamed A Baba Ahmed Kharbach Mohamed Lmejjati Nawal Adali Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study Journal of Public Health in Africa cancer glioblastoma brain quality of life morocco |
| title | Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study |
| title_full | Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study |
| title_fullStr | Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study |
| title_full_unstemmed | Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study |
| title_short | Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study |
| title_sort | neurocognitive function and health related quality of life among glioblastoma patients a prospective study |
| topic | cancer glioblastoma brain quality of life morocco |
| url | https://publichealthinafrica.org/index.php/jphia/article/view/660 |
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