Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins
It is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell surface. It presents as a terminal structure on either glycoproteins or g...
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Open Exploration
2023-02-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A10084/10084.pdf |
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| author | Qiushi Chen Han Liu Xuechen Li |
| author_facet | Qiushi Chen Han Liu Xuechen Li |
| author_sort | Qiushi Chen |
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| description | It is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell surface. It presents as a terminal structure on either glycoproteins or glycolipids and has been demonstrated to be related to various biological processes, such as fertilization and selectin binding. Due to the vital role of sLeX, its synthesis as well as its determination approaches have attracted considerable attention from many researchers. In this review, the focus is sLeX on glycoproteins. The biological importance of sLeX in fertilization and development, immunity, cancers, and other aspects will be first introduced. Then the chemical and enzymatic synthesis of sLeX including the contributions from more than 15 international research groups will be described, followed by a brief view of the sLeX detection focusing on monosaccharides and linkages. This review is valuable for those readers who are interested in the chemistry and biology of sLeX. |
| format | Article |
| id | doaj-art-43616eb3f9e4471e8e1d9687f2638cc0 |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Open Exploration |
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| series | Exploration of Drug Science |
| spelling | doaj-art-43616eb3f9e4471e8e1d9687f2638cc02025-02-08T05:16:46ZengOpen ExplorationExploration of Drug Science2836-76772023-02-011315410.37349/eds.2023.00004Essential functions, syntheses and detection of sialyl Lewis X on glycoproteinsQiushi Chen0https://orcid.org/0000-0001-8355-2801Han Liu1https://orcid.org/0000-0003-1412-4584Xuechen Li2https://orcid.org/0000-0001-5465-7727Department of Chemistry, The University of Hong Kong, Hong Kong 999077, China; Laboratory for Synthetic Chemistry and Chemical Biology Limited, Hong Kong Science Park, Hong Kong 999077, ChinaDepartment of Chemistry, The University of Hong Kong, Hong Kong 999077, ChinaDepartment of Chemistry, The University of Hong Kong, Hong Kong 999077, ChinaIt is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell surface. It presents as a terminal structure on either glycoproteins or glycolipids and has been demonstrated to be related to various biological processes, such as fertilization and selectin binding. Due to the vital role of sLeX, its synthesis as well as its determination approaches have attracted considerable attention from many researchers. In this review, the focus is sLeX on glycoproteins. The biological importance of sLeX in fertilization and development, immunity, cancers, and other aspects will be first introduced. Then the chemical and enzymatic synthesis of sLeX including the contributions from more than 15 international research groups will be described, followed by a brief view of the sLeX detection focusing on monosaccharides and linkages. This review is valuable for those readers who are interested in the chemistry and biology of sLeX.https://www.explorationpub.com/uploads/Article/A10084/10084.pdfsialyl lewis xbiological functionsynthesismass spectrometryglycoproteins |
| spellingShingle | Qiushi Chen Han Liu Xuechen Li Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins Exploration of Drug Science sialyl lewis x biological function synthesis mass spectrometry glycoproteins |
| title | Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins |
| title_full | Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins |
| title_fullStr | Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins |
| title_full_unstemmed | Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins |
| title_short | Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins |
| title_sort | essential functions syntheses and detection of sialyl lewis x on glycoproteins |
| topic | sialyl lewis x biological function synthesis mass spectrometry glycoproteins |
| url | https://www.explorationpub.com/uploads/Article/A10084/10084.pdf |
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