Impact of Postpartum Dexamethasone on Postpartum Disease Stabilization in Women with HELLP Syndrome
OBJECTIVE: To investigate the impact of postpartum corticosteroid therapy on maternal disease in women with HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome. STUDY DESIGN: Thirty-eight patients diagnosed with HELLP syndrome were randomly assigned to treatment (n= 19) and contro...
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| Format: | Article |
| Language: | English |
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Medical Network
2015-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/4 |
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| author | Ayla Sargın Oruç Figen Türkçapar Serdar Oğuz Necati Hançerlioğulları Ümit Bilge Nuri Danışman |
| author_facet | Ayla Sargın Oruç Figen Türkçapar Serdar Oğuz Necati Hançerlioğulları Ümit Bilge Nuri Danışman |
| author_sort | Ayla Sargın Oruç |
| collection | DOAJ |
| description |
OBJECTIVE: To investigate the impact of postpartum corticosteroid therapy on maternal disease in women with HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome.
STUDY DESIGN: Thirty-eight patients diagnosed with HELLP syndrome were randomly assigned to treatment (n= 19) and control (n=19) groups. Patients in the treatment group were administered dexamethasone 8 mg, 4 mg and 2 mg IV twice daily, on the postoperative days 1, 2 and 3 consecutively. The first dose was given immediately postpartum. Mean arterial pressure, platelet count , aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels were determined every 6 hours. Duration of intensive care and urinary output were also investigated.
RESULTS: Relative to the control group, the mean arterial pressure became significantly decreased at 42 hours in the steroid-treated group (p = 0.0035), the platelet count increased significantly by 24 hours (p<0.05), and AST and ALT decreased significantly by 24 and 18 hours respectively (p=0.02 and p = 0.01, respectively). Treatment group had higher mean platelet count for all time intervals and the difference between the groups was significant after the postpartum 42nd hour (p=0.03).
CONCLUSION: We observed a rapid resolution of the laboratory and clinical parameters in patients with HELLP syndrome treated with corticosteroids postpartum. We postulate that use of this therapeutic approach could result in reduced overall maternal morbidity and mortality, shorter intensive-care unit stay, with reduced medical care costs.
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| format | Article |
| id | doaj-art-4452d3c3bf0e4bec931552d216a9c73b |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-4452d3c3bf0e4bec931552d216a9c73b2025-02-11T21:26:20ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182015-12-012134Impact of Postpartum Dexamethasone on Postpartum Disease Stabilization in Women with HELLP SyndromeAyla Sargın Oruç0Figen Türkçapar1Serdar Oğuz2Necati Hançerlioğulları3Ümit Bilge4Nuri Danışman5Zekai Tahir Burak Women’s Health Teaching and Research Hospital, AnkaraZekai Tahir Burak Women’s Health Teaching and Research Hospital, AnkaraZekai Tahir Burak Women’s Health Teaching and Research Hospital, AnkaraZekai Tahir Burak Women’s Health Teaching and Research Hospital, AnkaraZekai Tahir Burak Women’s Health Teaching and Research Hospital, AnkaraZekai Tahir Burak Women’s Health Teaching and Research Hospital, Ankara OBJECTIVE: To investigate the impact of postpartum corticosteroid therapy on maternal disease in women with HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome. STUDY DESIGN: Thirty-eight patients diagnosed with HELLP syndrome were randomly assigned to treatment (n= 19) and control (n=19) groups. Patients in the treatment group were administered dexamethasone 8 mg, 4 mg and 2 mg IV twice daily, on the postoperative days 1, 2 and 3 consecutively. The first dose was given immediately postpartum. Mean arterial pressure, platelet count , aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels were determined every 6 hours. Duration of intensive care and urinary output were also investigated. RESULTS: Relative to the control group, the mean arterial pressure became significantly decreased at 42 hours in the steroid-treated group (p = 0.0035), the platelet count increased significantly by 24 hours (p<0.05), and AST and ALT decreased significantly by 24 and 18 hours respectively (p=0.02 and p = 0.01, respectively). Treatment group had higher mean platelet count for all time intervals and the difference between the groups was significant after the postpartum 42nd hour (p=0.03). CONCLUSION: We observed a rapid resolution of the laboratory and clinical parameters in patients with HELLP syndrome treated with corticosteroids postpartum. We postulate that use of this therapeutic approach could result in reduced overall maternal morbidity and mortality, shorter intensive-care unit stay, with reduced medical care costs. https://gorm.com.tr/index.php/GORM/article/view/4PreeclampsiaHELLPCorticosteroids |
| spellingShingle | Ayla Sargın Oruç Figen Türkçapar Serdar Oğuz Necati Hançerlioğulları Ümit Bilge Nuri Danışman Impact of Postpartum Dexamethasone on Postpartum Disease Stabilization in Women with HELLP Syndrome Gynecology Obstetrics & Reproductive Medicine Preeclampsia HELLP Corticosteroids |
| title | Impact of Postpartum Dexamethasone on Postpartum Disease Stabilization in Women with HELLP Syndrome |
| title_full | Impact of Postpartum Dexamethasone on Postpartum Disease Stabilization in Women with HELLP Syndrome |
| title_fullStr | Impact of Postpartum Dexamethasone on Postpartum Disease Stabilization in Women with HELLP Syndrome |
| title_full_unstemmed | Impact of Postpartum Dexamethasone on Postpartum Disease Stabilization in Women with HELLP Syndrome |
| title_short | Impact of Postpartum Dexamethasone on Postpartum Disease Stabilization in Women with HELLP Syndrome |
| title_sort | impact of postpartum dexamethasone on postpartum disease stabilization in women with hellp syndrome |
| topic | Preeclampsia HELLP Corticosteroids |
| url | https://gorm.com.tr/index.php/GORM/article/view/4 |
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