NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication
Abstract The rise of antibiotic resistance has made bacterial infections a persistent global health issue. In particular, extracellular polymeric substances (EPS) secreted by bacteria limit the effectiveness of conventional antibiotics, making biofilm removal challenging. To address this, we created...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Biological Engineering |
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| Online Access: | https://doi.org/10.1186/s13036-024-00469-6 |
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| author | Hyeonseo Park Tejal V. Patil Jieun Lee Hojin Kim Seong-Jun Cho Ki-Taek Lim |
| author_facet | Hyeonseo Park Tejal V. Patil Jieun Lee Hojin Kim Seong-Jun Cho Ki-Taek Lim |
| author_sort | Hyeonseo Park |
| collection | DOAJ |
| description | Abstract The rise of antibiotic resistance has made bacterial infections a persistent global health issue. In particular, extracellular polymeric substances (EPS) secreted by bacteria limit the effectiveness of conventional antibiotics, making biofilm removal challenging. To address this, we created ND@PDA nanoparticles by coating the surface of nanodiamonds (ND) with polydopamine (PDA). These nanoparticles were then integrated into polyvinyl alcohol to fabricate PVA/ND@PDA nanofiber scaffolds, resulting in an innovative platform with enhanced photothermal, antibacterial and antibiofilm properties. Upon exposure to near-infrared (NIR) light, the scaffolds exhibited a significant photothermal activity, oxidative stress and effectively damaging key bacterial components, such as biofilm, bacterial membranes, and proteins. Additionally, the catechol groups in PDA provided strong cell adhesion and high biocompatibility on the nanofiber surface. Our research proposes a platform that not only effectively addresses antibiotic-resistant infections but also contributes to advancements in wound healing therapies by enabling controlled antibacterial action with minimal toxicity. |
| format | Article |
| id | doaj-art-453f8c5874f84409be60ee53f9d555f2 |
| institution | Kabale University |
| issn | 1754-1611 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biological Engineering |
| spelling | doaj-art-453f8c5874f84409be60ee53f9d555f22025-02-09T12:41:02ZengBMCJournal of Biological Engineering1754-16112025-02-0119112210.1186/s13036-024-00469-6NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradicationHyeonseo Park0Tejal V. Patil1Jieun Lee2Hojin Kim3Seong-Jun Cho4Ki-Taek Lim5Department of Biosystems Engineering, Kangwon National UniversityDepartment of Biosystems Engineering, Kangwon National UniversityDepartment of Biosystems Engineering, Kangwon National UniversityDepartment of Biosystems Engineering, Kangwon National UniversityDepartment of Food Science and Biotechnology, Kangwon National UniversityDepartment of Biosystems Engineering, Kangwon National UniversityAbstract The rise of antibiotic resistance has made bacterial infections a persistent global health issue. In particular, extracellular polymeric substances (EPS) secreted by bacteria limit the effectiveness of conventional antibiotics, making biofilm removal challenging. To address this, we created ND@PDA nanoparticles by coating the surface of nanodiamonds (ND) with polydopamine (PDA). These nanoparticles were then integrated into polyvinyl alcohol to fabricate PVA/ND@PDA nanofiber scaffolds, resulting in an innovative platform with enhanced photothermal, antibacterial and antibiofilm properties. Upon exposure to near-infrared (NIR) light, the scaffolds exhibited a significant photothermal activity, oxidative stress and effectively damaging key bacterial components, such as biofilm, bacterial membranes, and proteins. Additionally, the catechol groups in PDA provided strong cell adhesion and high biocompatibility on the nanofiber surface. Our research proposes a platform that not only effectively addresses antibiotic-resistant infections but also contributes to advancements in wound healing therapies by enabling controlled antibacterial action with minimal toxicity.https://doi.org/10.1186/s13036-024-00469-6ND@PDANIRPhotothermalROSAntibacterialBiofilm |
| spellingShingle | Hyeonseo Park Tejal V. Patil Jieun Lee Hojin Kim Seong-Jun Cho Ki-Taek Lim NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication Journal of Biological Engineering ND@PDA NIR Photothermal ROS Antibacterial Biofilm |
| title | NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication |
| title_full | NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication |
| title_fullStr | NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication |
| title_full_unstemmed | NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication |
| title_short | NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication |
| title_sort | nir activated catechol functionalized nanodiamond nanofibers for accelerating on demand mrsa and e coli biofilm eradication |
| topic | ND@PDA NIR Photothermal ROS Antibacterial Biofilm |
| url | https://doi.org/10.1186/s13036-024-00469-6 |
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