Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity?
Chronic graft-versus-host disease is a common complication after allogeneic hematopoietic stem cell transplantation, with pulmonary chronic graft-versus-host disease (PcGvHD) particularly associated with a dismal prognosis. Lung transplantation (LuTx) is a final therapeutic option for well-selected...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | JHLT Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950133425000047 |
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| author | Andrea Zajacova, MD Hélène Schoemans, MD, PhD Mark Greer, MD, MRCP Hildegard Greinix, MD Peter Jaksch, MD Osnat Shtraichman, MD Rayid Abdulqawi, MD, PhD Are M. Holm, MD, PhD Robin Vos, MD, PhD Saskia Bos, MD, PhD |
| author_facet | Andrea Zajacova, MD Hélène Schoemans, MD, PhD Mark Greer, MD, MRCP Hildegard Greinix, MD Peter Jaksch, MD Osnat Shtraichman, MD Rayid Abdulqawi, MD, PhD Are M. Holm, MD, PhD Robin Vos, MD, PhD Saskia Bos, MD, PhD |
| author_sort | Andrea Zajacova, MD |
| collection | DOAJ |
| description | Chronic graft-versus-host disease is a common complication after allogeneic hematopoietic stem cell transplantation, with pulmonary chronic graft-versus-host disease (PcGvHD) particularly associated with a dismal prognosis. Lung transplantation (LuTx) is a final therapeutic option for well-selected patients affected by this condition. Nevertheless, only a small group of PcGvHD patients are referred for LuTx. This review addresses common concerns regarding referral and listing of PcGvHD patients for LuTx (such as risk of relapse of hematological malignancy, infectious complications and rejection) and survival outcomes of this specific cohort of patients. Importantly, LuTx for PcGvHD has comparable outcomes to other indications. The establishment of specific LuTx indication criteria for PcGvHD patients may improve referral rates and timing of both referral and listing of suitable candidates. |
| format | Article |
| id | doaj-art-45a24bd9698644c1b7b46ba8e07618eb |
| institution | Kabale University |
| issn | 2950-1334 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JHLT Open |
| spelling | doaj-art-45a24bd9698644c1b7b46ba8e07618eb2025-02-09T05:02:03ZengElsevierJHLT Open2950-13342025-02-017100209Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity?Andrea Zajacova, MD0Hélène Schoemans, MD, PhD1Mark Greer, MD, MRCP2Hildegard Greinix, MD3Peter Jaksch, MD4Osnat Shtraichman, MD5Rayid Abdulqawi, MD, PhD6Are M. Holm, MD, PhD7Robin Vos, MD, PhD8Saskia Bos, MD, PhD9Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium; Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Dept. of CHROMETA, KU Leuven, Leuven, BelgiumDepartment of Haematology, Bone marrow Transplant Unit, University Hospitals Leuven, Leuven, Belgium; KU Leuven, Department of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, Leuven, BelgiumDepartment of Respiratory Medicine & Infectious Diseases, Hannover Medical School, Hannover, GermanyDivision of Haematology Medical University Graz, Graz, AustriaDepartment of Thoracic Surgery, Medical University of Vienna, Vienna, AustriaPulmonary Institute, Rabin Medical Center, Affiliated with Sackler School of Medicine Tel Aviv University, Petach Tikva, IsraelLung Health Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi ArabiaDept of Respiratory Medicine, Oslo University Hospital, Oslo, NorwayDepartment of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium; Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Dept. of CHROMETA, KU Leuven, Leuven, BelgiumDepartment of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium; Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Dept. of CHROMETA, KU Leuven, Leuven, Belgium; Reprint requests: Dr. Saskia Bos, Dept. of Respiratory Diseases, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.Chronic graft-versus-host disease is a common complication after allogeneic hematopoietic stem cell transplantation, with pulmonary chronic graft-versus-host disease (PcGvHD) particularly associated with a dismal prognosis. Lung transplantation (LuTx) is a final therapeutic option for well-selected patients affected by this condition. Nevertheless, only a small group of PcGvHD patients are referred for LuTx. This review addresses common concerns regarding referral and listing of PcGvHD patients for LuTx (such as risk of relapse of hematological malignancy, infectious complications and rejection) and survival outcomes of this specific cohort of patients. Importantly, LuTx for PcGvHD has comparable outcomes to other indications. The establishment of specific LuTx indication criteria for PcGvHD patients may improve referral rates and timing of both referral and listing of suitable candidates.http://www.sciencedirect.com/science/article/pii/S2950133425000047Lung transplantationPulmonary graft-versus-host diseaseBronchiolitis obliteransSyndromeRestrictive allograft syndromeGvHD |
| spellingShingle | Andrea Zajacova, MD Hélène Schoemans, MD, PhD Mark Greer, MD, MRCP Hildegard Greinix, MD Peter Jaksch, MD Osnat Shtraichman, MD Rayid Abdulqawi, MD, PhD Are M. Holm, MD, PhD Robin Vos, MD, PhD Saskia Bos, MD, PhD Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity? JHLT Open Lung transplantation Pulmonary graft-versus-host disease Bronchiolitis obliterans Syndrome Restrictive allograft syndrome GvHD |
| title | Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity? |
| title_full | Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity? |
| title_fullStr | Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity? |
| title_full_unstemmed | Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity? |
| title_short | Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity? |
| title_sort | lung transplantation for pulmonary chronic graft versus host disease a missed opportunity |
| topic | Lung transplantation Pulmonary graft-versus-host disease Bronchiolitis obliterans Syndrome Restrictive allograft syndrome GvHD |
| url | http://www.sciencedirect.com/science/article/pii/S2950133425000047 |
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