The Association between Abnormal Vaginal Flora and Cytological Evidence of HPV with Prematurity in High-Risk Pregnant Women
Objective: To evaluate the association between abnormal vaginal flora and cytological evidence of HPV with prematurity in high-risk pregnant women. Study design: A prospective cohort study was designed with high-risk pregnant women who delivered singletons between 20-42 gestational weeks between...
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| Format: | Article |
| Language: | English |
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Medical Network
2020-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/928 |
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| author | Alana Dantas Freire Ada Isa Custódio José Queiroz Filho Janaína Crispim Freitas Ana Katherine Gonçalves Ricardo Ney Cobucci |
| author_facet | Alana Dantas Freire Ada Isa Custódio José Queiroz Filho Janaína Crispim Freitas Ana Katherine Gonçalves Ricardo Ney Cobucci |
| author_sort | Alana Dantas Freire |
| collection | DOAJ |
| description |
Objective: To evaluate the association between abnormal vaginal flora and cytological evidence of HPV with prematurity in high-risk pregnant women.
Study design: A prospective cohort study was designed with high-risk pregnant women who delivered singletons between 20-42 gestational weeks between January to November 2018. Vaginal specimens were collected to obtain material from the upper lateral vaginal vault and cervix for direct microscopic examination of vaginal contents and preparation of Gram-stained and pap smear slides. Potential determinants of infection were assessed using the chi-square test. Poisson regression was used to determine the prevalence ratio and 95% confidence interval of the association between the vaginal flora and cytology with prematurity and a p <0.05 was considered as statistical significance.
Results: A total of 68 pap smear and high vaginal swab samples were collected from high-risk pregnant women with a mean age of 30.3 years. There were 26 (38.2%) cases of abnormal vaginal flora and 6 (8.8%) of HPV-induced cytological abnormalities. The preterm delivery rate was comparable between women with normal and abnormal vaginal flora (11.9% vs. 11.5%, prevalence ratio 1.0 [95% confidence interval: 0.8-1.2], aPR 1.0 [95% confidence interval: 0.8-1.2]) and between women with and without abnormal cytology (16.7% vs. 11.3%, prevalence ratio 0.9 [95% confidence interval: 0.6-1.4], aPR 0.9 [95% confidence interval: 0.6-1.4]).
Conclusions: We determined no association between abnormal cytology or altered vaginal flora in high-risk pregnancy in terms of overall preterm birth rate.
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| format | Article |
| id | doaj-art-46f8bbf6b47a408999d1998f40e0e6c2 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-46f8bbf6b47a408999d1998f40e0e6c22025-02-11T21:10:43ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182020-12-0126310.21613/GORM.2019.928The Association between Abnormal Vaginal Flora and Cytological Evidence of HPV with Prematurity in High-Risk Pregnant WomenAlana Dantas Freire0Ada Isa Custódio1José Queiroz Filho2Janaína Crispim Freitas3Ana Katherine Gonçalves4Ricardo Ney Cobucci5Federal University of Rio Grande do Norte (UFRN)Federal University of Rio Grande do Norte (UFRN)Federal University of Rio Grande do Norte (UFRN)Federal University of Rio Grande do Norte (UFRN)Federal University of Rio Grande do Norte (UFRN)Potiguar University- UnP Objective: To evaluate the association between abnormal vaginal flora and cytological evidence of HPV with prematurity in high-risk pregnant women. Study design: A prospective cohort study was designed with high-risk pregnant women who delivered singletons between 20-42 gestational weeks between January to November 2018. Vaginal specimens were collected to obtain material from the upper lateral vaginal vault and cervix for direct microscopic examination of vaginal contents and preparation of Gram-stained and pap smear slides. Potential determinants of infection were assessed using the chi-square test. Poisson regression was used to determine the prevalence ratio and 95% confidence interval of the association between the vaginal flora and cytology with prematurity and a p <0.05 was considered as statistical significance. Results: A total of 68 pap smear and high vaginal swab samples were collected from high-risk pregnant women with a mean age of 30.3 years. There were 26 (38.2%) cases of abnormal vaginal flora and 6 (8.8%) of HPV-induced cytological abnormalities. The preterm delivery rate was comparable between women with normal and abnormal vaginal flora (11.9% vs. 11.5%, prevalence ratio 1.0 [95% confidence interval: 0.8-1.2], aPR 1.0 [95% confidence interval: 0.8-1.2]) and between women with and without abnormal cytology (16.7% vs. 11.3%, prevalence ratio 0.9 [95% confidence interval: 0.6-1.4], aPR 0.9 [95% confidence interval: 0.6-1.4]). Conclusions: We determined no association between abnormal cytology or altered vaginal flora in high-risk pregnancy in terms of overall preterm birth rate. https://gorm.com.tr/index.php/GORM/article/view/928High-riskPapanicolaou testPregnancyVaginal infection |
| spellingShingle | Alana Dantas Freire Ada Isa Custódio José Queiroz Filho Janaína Crispim Freitas Ana Katherine Gonçalves Ricardo Ney Cobucci The Association between Abnormal Vaginal Flora and Cytological Evidence of HPV with Prematurity in High-Risk Pregnant Women Gynecology Obstetrics & Reproductive Medicine High-risk Papanicolaou test Pregnancy Vaginal infection |
| title | The Association between Abnormal Vaginal Flora and Cytological Evidence of HPV with Prematurity in High-Risk Pregnant Women |
| title_full | The Association between Abnormal Vaginal Flora and Cytological Evidence of HPV with Prematurity in High-Risk Pregnant Women |
| title_fullStr | The Association between Abnormal Vaginal Flora and Cytological Evidence of HPV with Prematurity in High-Risk Pregnant Women |
| title_full_unstemmed | The Association between Abnormal Vaginal Flora and Cytological Evidence of HPV with Prematurity in High-Risk Pregnant Women |
| title_short | The Association between Abnormal Vaginal Flora and Cytological Evidence of HPV with Prematurity in High-Risk Pregnant Women |
| title_sort | association between abnormal vaginal flora and cytological evidence of hpv with prematurity in high risk pregnant women |
| topic | High-risk Papanicolaou test Pregnancy Vaginal infection |
| url | https://gorm.com.tr/index.php/GORM/article/view/928 |
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