Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapy
Background and purpose: Despite recognizing the effectiveness of carbon-ion radiotherapy (C-ion RT) in treating head and neck adenoid cystic carcinoma (HN-ACC), the impact of perineural tumor spread (PNTS) on treatment outcomes and the relationship between PNTS and post-treatment marginal recurrence...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Clinical and Translational Radiation Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405630825000187 |
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| author | Atsushi Musha Nobuteru Kubo Hidemasa Kawamura Naoko Okano Masahiro Onishi Takeru Ohtaka Midori Tamura Osamu Nikkuni Yuichi Tomidokoro Satoshi Yokoo Kazuaki Chikamatsu Tatsuya Ohno |
| author_facet | Atsushi Musha Nobuteru Kubo Hidemasa Kawamura Naoko Okano Masahiro Onishi Takeru Ohtaka Midori Tamura Osamu Nikkuni Yuichi Tomidokoro Satoshi Yokoo Kazuaki Chikamatsu Tatsuya Ohno |
| author_sort | Atsushi Musha |
| collection | DOAJ |
| description | Background and purpose: Despite recognizing the effectiveness of carbon-ion radiotherapy (C-ion RT) in treating head and neck adenoid cystic carcinoma (HN-ACC), the impact of perineural tumor spread (PNTS) on treatment outcomes and the relationship between PNTS and post-treatment marginal recurrences remain unexplored. Therefore, we analyzed the efficacy of C-ion RT in HN-ACC, focusing on PNTS including details of post-treatment marginal recurrence and indicators for future treatment strategies. Materials and methods: In this retrospective study, we included 74 patients diagnosed with HN-ACC who underwent C-ion RT between June 2010 and July 2022. Treatment dosages were either 57.6 or 64.0 Gy (relative biological effectiveness) delivered in 16 fractions. Patients undergoing C-ion RT were identified retrospectively from medical records. PNTS was evaluated by magnetic resonance imaging for detecting extratumoral extension to peritumoral nerves. Results: The median duration of follow-up was 46.4 months. Local recurrence developed in 19 patients. Moreover, most marginal recurrences occurred within the irradiated margins. The 5-year rates for local control (LC), progression-free survival (PFS), and overall survival (OS) were 67.6 %, 47.7 %, and 79.0 %, respectively. LC (p = 0.005) and PFS (p = 0.013) demonstrated significant variances on analysis based on PNTS occurrence; however, OS did not exhibit a similar pattern. Conclusion: Our findings highlight the importance for considering disease-specific characteristics and the need for developing targeted strategies that address the complex nature of HN-ACC, particularly in cases involving PNTS, to enhance treatment outcomes and potentially reduce recurrence rates. |
| format | Article |
| id | doaj-art-46ff2c9026ae4af0bdf036dd8487b949 |
| institution | Kabale University |
| issn | 2405-6308 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical and Translational Radiation Oncology |
| spelling | doaj-art-46ff2c9026ae4af0bdf036dd8487b9492025-02-07T04:47:51ZengElsevierClinical and Translational Radiation Oncology2405-63082025-05-0152100928Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapyAtsushi Musha0Nobuteru Kubo1Hidemasa Kawamura2Naoko Okano3Masahiro Onishi4Takeru Ohtaka5Midori Tamura6Osamu Nikkuni7Yuichi Tomidokoro8Satoshi Yokoo9Kazuaki Chikamatsu10Tatsuya Ohno11Gunma University Heavy Ion Medical Center, Maebashi, Gunma 371-8511, Japan; Department of Oral and Maxillofacial Surgery and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan; Corresponding author at: Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan.Gunma University Heavy Ion Medical Center, Maebashi, Gunma 371-8511, JapanGunma University Heavy Ion Medical Center, Maebashi, Gunma 371-8511, JapanGunma University Heavy Ion Medical Center, Maebashi, Gunma 371-8511, JapanGunma University Heavy Ion Medical Center, Maebashi, Gunma 371-8511, JapanGunma University Heavy Ion Medical Center, Maebashi, Gunma 371-8511, JapanGunma University Heavy Ion Medical Center, Maebashi, Gunma 371-8511, JapanDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, JapanDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, JapanDepartment of Oral and Maxillofacial Surgery and Plastic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, JapanDepartment of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, JapanGunma University Heavy Ion Medical Center, Maebashi, Gunma 371-8511, JapanBackground and purpose: Despite recognizing the effectiveness of carbon-ion radiotherapy (C-ion RT) in treating head and neck adenoid cystic carcinoma (HN-ACC), the impact of perineural tumor spread (PNTS) on treatment outcomes and the relationship between PNTS and post-treatment marginal recurrences remain unexplored. Therefore, we analyzed the efficacy of C-ion RT in HN-ACC, focusing on PNTS including details of post-treatment marginal recurrence and indicators for future treatment strategies. Materials and methods: In this retrospective study, we included 74 patients diagnosed with HN-ACC who underwent C-ion RT between June 2010 and July 2022. Treatment dosages were either 57.6 or 64.0 Gy (relative biological effectiveness) delivered in 16 fractions. Patients undergoing C-ion RT were identified retrospectively from medical records. PNTS was evaluated by magnetic resonance imaging for detecting extratumoral extension to peritumoral nerves. Results: The median duration of follow-up was 46.4 months. Local recurrence developed in 19 patients. Moreover, most marginal recurrences occurred within the irradiated margins. The 5-year rates for local control (LC), progression-free survival (PFS), and overall survival (OS) were 67.6 %, 47.7 %, and 79.0 %, respectively. LC (p = 0.005) and PFS (p = 0.013) demonstrated significant variances on analysis based on PNTS occurrence; however, OS did not exhibit a similar pattern. Conclusion: Our findings highlight the importance for considering disease-specific characteristics and the need for developing targeted strategies that address the complex nature of HN-ACC, particularly in cases involving PNTS, to enhance treatment outcomes and potentially reduce recurrence rates.http://www.sciencedirect.com/science/article/pii/S2405630825000187Adenoid cystic carcinomaCarbon-ion radiotherapyPerineural tumor spreadHead and neck tumorTreatment outcome |
| spellingShingle | Atsushi Musha Nobuteru Kubo Hidemasa Kawamura Naoko Okano Masahiro Onishi Takeru Ohtaka Midori Tamura Osamu Nikkuni Yuichi Tomidokoro Satoshi Yokoo Kazuaki Chikamatsu Tatsuya Ohno Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapy Clinical and Translational Radiation Oncology Adenoid cystic carcinoma Carbon-ion radiotherapy Perineural tumor spread Head and neck tumor Treatment outcome |
| title | Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapy |
| title_full | Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapy |
| title_fullStr | Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapy |
| title_full_unstemmed | Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapy |
| title_short | Impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon-ion radiotherapy |
| title_sort | impact of perineural tumor spread in head and neck adenoid cystic carcinoma for carbon ion radiotherapy |
| topic | Adenoid cystic carcinoma Carbon-ion radiotherapy Perineural tumor spread Head and neck tumor Treatment outcome |
| url | http://www.sciencedirect.com/science/article/pii/S2405630825000187 |
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