Comparative evaluation of APRI and MELD scores in the prediction of complications of chronic hepatitis in patients infected with hepatitis B or C viruses in Lubumbashi, democratic republic of Congo
The indication for treatment of viral hepatitis B and C depends on the degree of deterioration of liver function and secondarily viral load. APRI and MELD scores are WHO-validated tests for the assessment of liver fibrosis. They are inexpensive and non-invasive. Many patients suffer from viral hepat...
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Elsevier
2025-02-01
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| Series: | Journal of Clinical Virology Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667038024000255 |
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| author | Arsène Kabamba-Tshikongo Adolphe Baleebenga Bernard Kalunga-Tompa Claude Mwamba-Mulumba Henry Manya-Mboni Cedrick Mutombo-Shakalenga Pierrot Mwamba-Tshilumba Sébastien Bontems Géraldine Dessilly Benoît Kabamba-Mukadi Albert Longanga-Otshudi |
| author_facet | Arsène Kabamba-Tshikongo Adolphe Baleebenga Bernard Kalunga-Tompa Claude Mwamba-Mulumba Henry Manya-Mboni Cedrick Mutombo-Shakalenga Pierrot Mwamba-Tshilumba Sébastien Bontems Géraldine Dessilly Benoît Kabamba-Mukadi Albert Longanga-Otshudi |
| author_sort | Arsène Kabamba-Tshikongo |
| collection | DOAJ |
| description | The indication for treatment of viral hepatitis B and C depends on the degree of deterioration of liver function and secondarily viral load. APRI and MELD scores are WHO-validated tests for the assessment of liver fibrosis. They are inexpensive and non-invasive. Many patients suffer from viral hepatitis B or C in the Democratic Republic of Congo. These scores are an asset in the medical management of these patients. The objective of this study was to compare APRI and MELD scores in the prediction of fibrosis in patients with chronic viral hepatitis B in Lubumbashi. It included infected patients followed in the gastroenterology departments of the hospitals of Lubumbashi and the Center of Excellence and Expertise for Viral Hepatitis and other Pathologies (CEEHP). Biological parameters of patient samples were evaluated to calculate APRI and MELD scores. Analytical performance of APRI and MELD scores was evaluated by using liver biopsy as gold standard.The APRI and MELD scores had a sensitivity of 100 % and a specificity of 93.5 and 88.6 %, respectively. In the fibrosis group of patients infected with HBV, the mean APRI score was of 1.89 whereas the mean MELD score was of 12.4 Incorporating these scores in routine clinical practice could reduce the morbidity rate, the costs related to the practice of liver biopsy and thus improve the routine management of viral hepatitis in Lubumbashi. |
| format | Article |
| id | doaj-art-479a49c80ad44d8ba3b06292ebea1999 |
| institution | Kabale University |
| issn | 2667-0380 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical Virology Plus |
| spelling | doaj-art-479a49c80ad44d8ba3b06292ebea19992025-02-08T05:01:32ZengElsevierJournal of Clinical Virology Plus2667-03802025-02-0151100200Comparative evaluation of APRI and MELD scores in the prediction of complications of chronic hepatitis in patients infected with hepatitis B or C viruses in Lubumbashi, democratic republic of CongoArsène Kabamba-Tshikongo0Adolphe Baleebenga1Bernard Kalunga-Tompa2Claude Mwamba-Mulumba3Henry Manya-Mboni4Cedrick Mutombo-Shakalenga5Pierrot Mwamba-Tshilumba6Sébastien Bontems7Géraldine Dessilly8Benoît Kabamba-Mukadi9Albert Longanga-Otshudi10Laboratoire de Biologie Clinique, Faculté des Sciences Pharmaceutiques, Université de Lubumbashi, Lubumbashi-Democratic Republic of the Congo; Centre d'Excellence et d'Expertise des Hépatites Virales et autres Pathologies, Lubumbashi-Democratic Republic of the Congo; Institut de Recherche Expérimentale et Clinique, Pôle de Microbiologie, Université Catholique de Louvain, Belgium; Corresponding author.Laboratoire de Biologie Clinique, Faculté des Sciences Pharmaceutiques, Université de Lubumbashi, Lubumbashi-Democratic Republic of the CongoLaboratoire de Biologie Clinique, Faculté des Sciences Pharmaceutiques, Université de Lubumbashi, Lubumbashi-Democratic Republic of the CongoDépartement de Médecine Interne, Faculté de Médecine, Université de Lubumbashi, Lubumbashi-Democratic Republic of the CongoLaboratoire de Biologie Clinique, Faculté des Sciences Pharmaceutiques, Université de Lubumbashi, Lubumbashi-Democratic Republic of the CongoLaboratoire de Biologie Clinique, Faculté des Sciences Pharmaceutiques, Université de Lubumbashi, Lubumbashi-Democratic Republic of the CongoLaboratoire de Biologie Clinique, Faculté des Sciences Pharmaceutiques, Université de Lubumbashi, Lubumbashi-Democratic Republic of the CongoLaboratoire de Microbiologie, Université de Liège, BelgiumInstitut de Recherche Expérimentale et Clinique, Pôle de Microbiologie, Université Catholique de Louvain, BelgiumInstitut de Recherche Expérimentale et Clinique, Pôle de Microbiologie, Université Catholique de Louvain, BelgiumLaboratoire de Biologie Clinique, Faculté des Sciences Pharmaceutiques, Université de Lubumbashi, Lubumbashi-Democratic Republic of the Congo; Centre d'Excellence et d'Expertise des Hépatites Virales et autres Pathologies, Lubumbashi-Democratic Republic of the CongoThe indication for treatment of viral hepatitis B and C depends on the degree of deterioration of liver function and secondarily viral load. APRI and MELD scores are WHO-validated tests for the assessment of liver fibrosis. They are inexpensive and non-invasive. Many patients suffer from viral hepatitis B or C in the Democratic Republic of Congo. These scores are an asset in the medical management of these patients. The objective of this study was to compare APRI and MELD scores in the prediction of fibrosis in patients with chronic viral hepatitis B in Lubumbashi. It included infected patients followed in the gastroenterology departments of the hospitals of Lubumbashi and the Center of Excellence and Expertise for Viral Hepatitis and other Pathologies (CEEHP). Biological parameters of patient samples were evaluated to calculate APRI and MELD scores. Analytical performance of APRI and MELD scores was evaluated by using liver biopsy as gold standard.The APRI and MELD scores had a sensitivity of 100 % and a specificity of 93.5 and 88.6 %, respectively. In the fibrosis group of patients infected with HBV, the mean APRI score was of 1.89 whereas the mean MELD score was of 12.4 Incorporating these scores in routine clinical practice could reduce the morbidity rate, the costs related to the practice of liver biopsy and thus improve the routine management of viral hepatitis in Lubumbashi.http://www.sciencedirect.com/science/article/pii/S2667038024000255FibrosisHepatitisCytolysisHBVHCVLubumbashi |
| spellingShingle | Arsène Kabamba-Tshikongo Adolphe Baleebenga Bernard Kalunga-Tompa Claude Mwamba-Mulumba Henry Manya-Mboni Cedrick Mutombo-Shakalenga Pierrot Mwamba-Tshilumba Sébastien Bontems Géraldine Dessilly Benoît Kabamba-Mukadi Albert Longanga-Otshudi Comparative evaluation of APRI and MELD scores in the prediction of complications of chronic hepatitis in patients infected with hepatitis B or C viruses in Lubumbashi, democratic republic of Congo Journal of Clinical Virology Plus Fibrosis Hepatitis Cytolysis HBV HCV Lubumbashi |
| title | Comparative evaluation of APRI and MELD scores in the prediction of complications of chronic hepatitis in patients infected with hepatitis B or C viruses in Lubumbashi, democratic republic of Congo |
| title_full | Comparative evaluation of APRI and MELD scores in the prediction of complications of chronic hepatitis in patients infected with hepatitis B or C viruses in Lubumbashi, democratic republic of Congo |
| title_fullStr | Comparative evaluation of APRI and MELD scores in the prediction of complications of chronic hepatitis in patients infected with hepatitis B or C viruses in Lubumbashi, democratic republic of Congo |
| title_full_unstemmed | Comparative evaluation of APRI and MELD scores in the prediction of complications of chronic hepatitis in patients infected with hepatitis B or C viruses in Lubumbashi, democratic republic of Congo |
| title_short | Comparative evaluation of APRI and MELD scores in the prediction of complications of chronic hepatitis in patients infected with hepatitis B or C viruses in Lubumbashi, democratic republic of Congo |
| title_sort | comparative evaluation of apri and meld scores in the prediction of complications of chronic hepatitis in patients infected with hepatitis b or c viruses in lubumbashi democratic republic of congo |
| topic | Fibrosis Hepatitis Cytolysis HBV HCV Lubumbashi |
| url | http://www.sciencedirect.com/science/article/pii/S2667038024000255 |
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