Intercellular communication is crucial in the regulation of healthy aging via exosomes
The hallmarks of aging encompass a variety of molecular categories (genomic, telomeric, and epigenetic), organelles (proteostasis, autophagy, and mitochondria), cellular components (including stem cells), systems (such as intercellular communication and chronic inflammation), and environmental facto...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825000167 |
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| author | Huifang Sun Tengyuan Xia Shuting Ma Tao Lv Yuhong Li |
| author_facet | Huifang Sun Tengyuan Xia Shuting Ma Tao Lv Yuhong Li |
| author_sort | Huifang Sun |
| collection | DOAJ |
| description | The hallmarks of aging encompass a variety of molecular categories (genomic, telomeric, and epigenetic), organelles (proteostasis, autophagy, and mitochondria), cellular components (including stem cells), systems (such as intercellular communication and chronic inflammation), and environmental factors (dysbiosis and nutrient sensing). These hallmarks play a crucial role in the aging process. Despite their intricate interconnections, the relationships among the hallmarks of aging remain unclear. Although the boundaries between these hallmarks may be indistinct, they exhibit interdependence, with the influence of one hallmark extending to others. Building on this foundation, we investigated the interrelations among the various hallmarks of aging and provided a systematic overview of their logical relationships, proposing that cellular communication plays a crucial role in the aging process. Exosomes function as a primary mode of cellular communication and significantly impact the aging process. Therefore, we propose utilizing exosomes as valuable tools for understanding the mechanisms of aging and addressing age-related concerns. Exosomes may represent a novel approach for the treatment and diagnosis of aging-related conditions in animals. Furthermore, our research reveals that exocytosis in young nematodes slows the aging process, while exocytosis in aged nematodes has the opposite effect, accelerating aging. In conclusion, exosomes act as intercellular messengers that influence the maintenance of a healthy aging process and link the hallmarks of aging with indicators of well-being. |
| format | Article |
| id | doaj-art-47bcd3fb441448cfb030f479544d7fbc |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-47bcd3fb441448cfb030f479544d7fbc2025-02-08T04:59:44ZengElsevierPharmacological Research1096-11862025-02-01212107591Intercellular communication is crucial in the regulation of healthy aging via exosomesHuifang Sun0Tengyuan Xia1Shuting Ma2Tao Lv3Yuhong Li4College of Biological and Food Engineering, Qujing Normal University, Qujing, Yunnan 655011, ChinaCollege of Biological and Food Engineering, Qujing Normal University, Qujing, Yunnan 655011, ChinaCollege of Biological and Food Engineering, Qujing Normal University, Qujing, Yunnan 655011, ChinaCorrespondence to: No. 222, Sanjiang Road, Economic and Technological Development Area, Qujing, Yunnan, China.; College of Biological and Food Engineering, Qujing Normal University, Qujing, Yunnan 655011, ChinaCorrespondence to: No. 222, Sanjiang Road, Economic and Technological Development Area, Qujing, Yunnan, China.; College of Biological and Food Engineering, Qujing Normal University, Qujing, Yunnan 655011, ChinaThe hallmarks of aging encompass a variety of molecular categories (genomic, telomeric, and epigenetic), organelles (proteostasis, autophagy, and mitochondria), cellular components (including stem cells), systems (such as intercellular communication and chronic inflammation), and environmental factors (dysbiosis and nutrient sensing). These hallmarks play a crucial role in the aging process. Despite their intricate interconnections, the relationships among the hallmarks of aging remain unclear. Although the boundaries between these hallmarks may be indistinct, they exhibit interdependence, with the influence of one hallmark extending to others. Building on this foundation, we investigated the interrelations among the various hallmarks of aging and provided a systematic overview of their logical relationships, proposing that cellular communication plays a crucial role in the aging process. Exosomes function as a primary mode of cellular communication and significantly impact the aging process. Therefore, we propose utilizing exosomes as valuable tools for understanding the mechanisms of aging and addressing age-related concerns. Exosomes may represent a novel approach for the treatment and diagnosis of aging-related conditions in animals. Furthermore, our research reveals that exocytosis in young nematodes slows the aging process, while exocytosis in aged nematodes has the opposite effect, accelerating aging. In conclusion, exosomes act as intercellular messengers that influence the maintenance of a healthy aging process and link the hallmarks of aging with indicators of well-being.http://www.sciencedirect.com/science/article/pii/S1043661825000167AgingCellular communicationExosomesLifestyle |
| spellingShingle | Huifang Sun Tengyuan Xia Shuting Ma Tao Lv Yuhong Li Intercellular communication is crucial in the regulation of healthy aging via exosomes Pharmacological Research Aging Cellular communication Exosomes Lifestyle |
| title | Intercellular communication is crucial in the regulation of healthy aging via exosomes |
| title_full | Intercellular communication is crucial in the regulation of healthy aging via exosomes |
| title_fullStr | Intercellular communication is crucial in the regulation of healthy aging via exosomes |
| title_full_unstemmed | Intercellular communication is crucial in the regulation of healthy aging via exosomes |
| title_short | Intercellular communication is crucial in the regulation of healthy aging via exosomes |
| title_sort | intercellular communication is crucial in the regulation of healthy aging via exosomes |
| topic | Aging Cellular communication Exosomes Lifestyle |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825000167 |
| work_keys_str_mv | AT huifangsun intercellularcommunicationiscrucialintheregulationofhealthyagingviaexosomes AT tengyuanxia intercellularcommunicationiscrucialintheregulationofhealthyagingviaexosomes AT shutingma intercellularcommunicationiscrucialintheregulationofhealthyagingviaexosomes AT taolv intercellularcommunicationiscrucialintheregulationofhealthyagingviaexosomes AT yuhongli intercellularcommunicationiscrucialintheregulationofhealthyagingviaexosomes |