Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018
BackgroundThe Magnesium Depletion Score (MDS) is a novel indicator that integrates multiple factors to assess systemic magnesium depletion. However, its association with hyperuricemia (HUA) prevalence remains unclear. This study aims to investigate the relationship between MDS and the prevalence of...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| author | Yongchun Xiao Yong Mou Yong Mou Ping Wu Ke Wang Tianjun Chen Zhiwan Chen Hongsheng Lin Hua Yang Zhisheng Ji |
| author_facet | Yongchun Xiao Yong Mou Yong Mou Ping Wu Ke Wang Tianjun Chen Zhiwan Chen Hongsheng Lin Hua Yang Zhisheng Ji |
| author_sort | Yongchun Xiao |
| collection | DOAJ |
| description | BackgroundThe Magnesium Depletion Score (MDS) is a novel indicator that integrates multiple factors to assess systemic magnesium depletion. However, its association with hyperuricemia (HUA) prevalence remains unclear. This study aims to investigate the relationship between MDS and the prevalence of HUA.MethodsA cross-sectional analysis was conducted using data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). The MDS was derived by integrating multiple risk factors associated with magnesium depletion: the use of diuretics and proton pump inhibitors (PPI), estimated glomerular filtration rate (eGFR), and alcohol consumption exceeding recommended thresholds. Univariable and multivariable logistic regression models assessed the association between MDS and HUA. Subgroup and sensitivity analyses, including the exclusion of gout patients, further evaluated this association.ResultsAmong 18,761 participants, higher MDS were associated with an increased prevalence of HUA. Multivariable logistic regression confirmed a significant positive association between MDS and HUA (OR = 1.73, 95% CI = 1.62-1.84). Restricted cubic splines (RCS) further characterized the non-linear relationship between MDS and HUA prevalence. Subgroup analysis indicated a positive association between MDS and HUA, with significant interactions observed for sex and body mass index. Sensitivity and additional analyses reinforced the robustness of these findings.ConclusionAmong U.S. adults, higher MDS were significantly associated with an increased prevalence of HUA, suggesting that interventions targeting magnesium deficiency could be beneficial in reducing HUA prevalence within this population. However, prospective studies are needed to further confirm these findings. |
| format | Article |
| id | doaj-art-4801962d5aa446e59e897ef5e0362bf0 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-4801962d5aa446e59e897ef5e0362bf02025-02-06T05:21:43ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.14386391438639Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018Yongchun Xiao0Yong Mou1Yong Mou2Ping Wu3Ke Wang4Tianjun Chen5Zhiwan Chen6Hongsheng Lin7Hua Yang8Zhisheng Ji9Department of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Microsurgery, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaBackgroundThe Magnesium Depletion Score (MDS) is a novel indicator that integrates multiple factors to assess systemic magnesium depletion. However, its association with hyperuricemia (HUA) prevalence remains unclear. This study aims to investigate the relationship between MDS and the prevalence of HUA.MethodsA cross-sectional analysis was conducted using data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). The MDS was derived by integrating multiple risk factors associated with magnesium depletion: the use of diuretics and proton pump inhibitors (PPI), estimated glomerular filtration rate (eGFR), and alcohol consumption exceeding recommended thresholds. Univariable and multivariable logistic regression models assessed the association between MDS and HUA. Subgroup and sensitivity analyses, including the exclusion of gout patients, further evaluated this association.ResultsAmong 18,761 participants, higher MDS were associated with an increased prevalence of HUA. Multivariable logistic regression confirmed a significant positive association between MDS and HUA (OR = 1.73, 95% CI = 1.62-1.84). Restricted cubic splines (RCS) further characterized the non-linear relationship between MDS and HUA prevalence. Subgroup analysis indicated a positive association between MDS and HUA, with significant interactions observed for sex and body mass index. Sensitivity and additional analyses reinforced the robustness of these findings.ConclusionAmong U.S. adults, higher MDS were significantly associated with an increased prevalence of HUA, suggesting that interventions targeting magnesium deficiency could be beneficial in reducing HUA prevalence within this population. However, prospective studies are needed to further confirm these findings.https://www.frontiersin.org/articles/10.3389/fendo.2025.1438639/fullmagnesium depletion scorehyperuricemiauric acidcross-sectional studyNHANES |
| spellingShingle | Yongchun Xiao Yong Mou Yong Mou Ping Wu Ke Wang Tianjun Chen Zhiwan Chen Hongsheng Lin Hua Yang Zhisheng Ji Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018 Frontiers in Endocrinology magnesium depletion score hyperuricemia uric acid cross-sectional study NHANES |
| title | Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018 |
| title_full | Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018 |
| title_fullStr | Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018 |
| title_full_unstemmed | Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018 |
| title_short | Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018 |
| title_sort | association between magnesium depletion score and prevalence of hyperuricemia in american adults a study based on nhanes 2007 2018 |
| topic | magnesium depletion score hyperuricemia uric acid cross-sectional study NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1438639/full |
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