Serum Ischemia Modified Albumin Levels in Infertile Couples Underwent in Vitro Fertilization
OBJECTIVE: Ischemia-modified albumin (IMA) is a novel biomarker for diagnosis of distinct disease states including infectious diseases, coronary atherosclerotic disease, hypoxic fetal distress and diabetes mellitus. In vitro fertilization (IVF) is a medical process by which an egg is fertilized by...
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Medical Network
2015-04-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/38 |
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| author | Fatma Beyazıt Osman Balcı Magdi Adam Hasan İnal Yeşim Bardakcı Nafiye Yılmaz |
| author_facet | Fatma Beyazıt Osman Balcı Magdi Adam Hasan İnal Yeşim Bardakcı Nafiye Yılmaz |
| author_sort | Fatma Beyazıt |
| collection | DOAJ |
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OBJECTIVE: Ischemia-modified albumin (IMA) is a novel biomarker for diagnosis of distinct disease states including infectious diseases, coronary atherosclerotic disease, hypoxic fetal distress and diabetes mellitus. In vitro fertilization (IVF) is a medical process by which an egg is fertilized by sperm outside the body with varible success rates. It is important for the clinician to assess which women will get pregnant after IVF procedure. In this context we aimed to analyse the possible role of IMA in infertile couples underwent IVF.
STUDY DESINGN: The study group comprised 30 patients with IVF failure, 27 patients with a successful IVF cycle and 34 fertile controls. IVF failure is defined as IVF that does not result in a pregnancy. A rapid, spectrophotometric Albumin Cobalt Binding (ACB) test was used to determine serum IMA levels and results were presented by absorbance units (ABSU).
RESULTS: Serum IMA levels were 0.27 (0.07-0.58), 0.35(0.08-0.88), and 0.37(0.06-1.07) ABSU for patients with IVF cycle failure, successful IVF cycle and controls respectively. No statistically significant difference was observed between study participants.
CONCLUSION: Our results showed that ischemia modified albumin did not provide enough sensitivity or specificity to determine IVF success.
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| format | Article |
| id | doaj-art-48955989e41f43bf88ff3c525c5c4ba5 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-48955989e41f43bf88ff3c525c5c4ba52025-02-11T21:25:23ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182015-04-0121133Serum Ischemia Modified Albumin Levels in Infertile Couples Underwent in Vitro FertilizationFatma Beyazıt0Osman Balcı1Magdi Adam2Hasan İnal3Yeşim Bardakcı4Nafiye Yılmaz5Department of Reproductive Endocrinology and IVF Department Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, AnkaraDepartment of Obstetrics and Gynecology Meram Medicine Faculty Selcuk University, KonyaDepartment of Reproductive Endocrinology and IVF Department Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, AnkaraDepartment of Reproductive Endocrinology and IVF Department Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, AnkaraDepartment of Reproductive Endocrinology and IVF, Laboratory of ART and Embryology Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, AnkaraDepartment of Reproductive Endocrinology and IVF Department Dr. Zekai Tahir Burak Women’s Health Education and Research Hospital, Ankara OBJECTIVE: Ischemia-modified albumin (IMA) is a novel biomarker for diagnosis of distinct disease states including infectious diseases, coronary atherosclerotic disease, hypoxic fetal distress and diabetes mellitus. In vitro fertilization (IVF) is a medical process by which an egg is fertilized by sperm outside the body with varible success rates. It is important for the clinician to assess which women will get pregnant after IVF procedure. In this context we aimed to analyse the possible role of IMA in infertile couples underwent IVF. STUDY DESINGN: The study group comprised 30 patients with IVF failure, 27 patients with a successful IVF cycle and 34 fertile controls. IVF failure is defined as IVF that does not result in a pregnancy. A rapid, spectrophotometric Albumin Cobalt Binding (ACB) test was used to determine serum IMA levels and results were presented by absorbance units (ABSU). RESULTS: Serum IMA levels were 0.27 (0.07-0.58), 0.35(0.08-0.88), and 0.37(0.06-1.07) ABSU for patients with IVF cycle failure, successful IVF cycle and controls respectively. No statistically significant difference was observed between study participants. CONCLUSION: Our results showed that ischemia modified albumin did not provide enough sensitivity or specificity to determine IVF success. https://gorm.com.tr/index.php/GORM/article/view/38In vitro fertilizationInfertilityIschemia modified albumin |
| spellingShingle | Fatma Beyazıt Osman Balcı Magdi Adam Hasan İnal Yeşim Bardakcı Nafiye Yılmaz Serum Ischemia Modified Albumin Levels in Infertile Couples Underwent in Vitro Fertilization Gynecology Obstetrics & Reproductive Medicine In vitro fertilization Infertility Ischemia modified albumin |
| title | Serum Ischemia Modified Albumin Levels in Infertile Couples Underwent in Vitro Fertilization |
| title_full | Serum Ischemia Modified Albumin Levels in Infertile Couples Underwent in Vitro Fertilization |
| title_fullStr | Serum Ischemia Modified Albumin Levels in Infertile Couples Underwent in Vitro Fertilization |
| title_full_unstemmed | Serum Ischemia Modified Albumin Levels in Infertile Couples Underwent in Vitro Fertilization |
| title_short | Serum Ischemia Modified Albumin Levels in Infertile Couples Underwent in Vitro Fertilization |
| title_sort | serum ischemia modified albumin levels in infertile couples underwent in vitro fertilization |
| topic | In vitro fertilization Infertility Ischemia modified albumin |
| url | https://gorm.com.tr/index.php/GORM/article/view/38 |
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