The WAVE complex in developmental and adulthood brain disorders
Abstract Actin polymerization and depolymerization are fundamental cellular processes required not only for the embryonic and postnatal development of the brain but also for the maintenance of neuronal plasticity and survival in the adult and aging brain. The orchestrated organization of actin filam...
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| Format: | Article |
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Nature Publishing Group
2025-01-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-024-01386-w |
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| author | Hyung-Goo Kim Clara Berdasco Angus C. Nairn Yong Kim |
| author_facet | Hyung-Goo Kim Clara Berdasco Angus C. Nairn Yong Kim |
| author_sort | Hyung-Goo Kim |
| collection | DOAJ |
| description | Abstract Actin polymerization and depolymerization are fundamental cellular processes required not only for the embryonic and postnatal development of the brain but also for the maintenance of neuronal plasticity and survival in the adult and aging brain. The orchestrated organization of actin filaments is controlled by various actin regulatory proteins. Wiskott‒Aldrich syndrome protein-family verprolin-homologous protein (WAVE) members are key activators of ARP2/3 complex-mediated actin polymerization. WAVE proteins exist as heteropentameric complexes together with regulatory proteins, including CYFIP, NCKAP, ABI and BRK1. The activity of the WAVE complex is tightly regulated by extracellular cues and intracellular signaling to execute its roles in specific intracellular events in brain cells. Notably, dysregulation of the WAVE complex and WAVE complex-mediated cellular processes confers vulnerability to a variety of brain disorders. De novo mutations in WAVE genes and other components of the WAVE complex have been identified in patients with developmental disorders such as intellectual disability, epileptic seizures, schizophrenia, and/or autism spectrum disorder. In addition, alterations in the WAVE complex are implicated in the pathophysiology of Alzheimer’s disease and Parkinson’s disease, as well as in behavioral adaptations to psychostimulants or maladaptive feeding. |
| format | Article |
| id | doaj-art-496d8ab799c74386922372b996c448fa |
| institution | Kabale University |
| issn | 2092-6413 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
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| series | Experimental and Molecular Medicine |
| spelling | doaj-art-496d8ab799c74386922372b996c448fa2025-02-09T12:14:11ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132025-01-01571132910.1038/s12276-024-01386-wThe WAVE complex in developmental and adulthood brain disordersHyung-Goo Kim0Clara Berdasco1Angus C. Nairn2Yong Kim3Department of Neurosurgery, Robert Wood Johnson Medical School, Rutgers UniversityDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers UniversityDepartment of Psychiatry, Yale School of Medicine, Connecticut Mental Health CenterDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers UniversityAbstract Actin polymerization and depolymerization are fundamental cellular processes required not only for the embryonic and postnatal development of the brain but also for the maintenance of neuronal plasticity and survival in the adult and aging brain. The orchestrated organization of actin filaments is controlled by various actin regulatory proteins. Wiskott‒Aldrich syndrome protein-family verprolin-homologous protein (WAVE) members are key activators of ARP2/3 complex-mediated actin polymerization. WAVE proteins exist as heteropentameric complexes together with regulatory proteins, including CYFIP, NCKAP, ABI and BRK1. The activity of the WAVE complex is tightly regulated by extracellular cues and intracellular signaling to execute its roles in specific intracellular events in brain cells. Notably, dysregulation of the WAVE complex and WAVE complex-mediated cellular processes confers vulnerability to a variety of brain disorders. De novo mutations in WAVE genes and other components of the WAVE complex have been identified in patients with developmental disorders such as intellectual disability, epileptic seizures, schizophrenia, and/or autism spectrum disorder. In addition, alterations in the WAVE complex are implicated in the pathophysiology of Alzheimer’s disease and Parkinson’s disease, as well as in behavioral adaptations to psychostimulants or maladaptive feeding.https://doi.org/10.1038/s12276-024-01386-w |
| spellingShingle | Hyung-Goo Kim Clara Berdasco Angus C. Nairn Yong Kim The WAVE complex in developmental and adulthood brain disorders Experimental and Molecular Medicine |
| title | The WAVE complex in developmental and adulthood brain disorders |
| title_full | The WAVE complex in developmental and adulthood brain disorders |
| title_fullStr | The WAVE complex in developmental and adulthood brain disorders |
| title_full_unstemmed | The WAVE complex in developmental and adulthood brain disorders |
| title_short | The WAVE complex in developmental and adulthood brain disorders |
| title_sort | wave complex in developmental and adulthood brain disorders |
| url | https://doi.org/10.1038/s12276-024-01386-w |
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