Cancer stem-like cells stay in a plastic state ready for tumor evolution
Cell plasticity emerges as a novel cancer hallmark and is pivotal in driving tumor heterogeneity and adaptive resistance to different therapies. Cancer stem-like cells (CSCs) are considered the root of cancer. While first defined as tumor-initiating cells with the potential to develop a heterogeneou...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558625000132 |
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| _version_ | 1825199410055741440 |
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| author | Jiali Xu Houde Zhang Zhihao Nie Wenyou He Yichao Zhao Zhenhui Huang Lin Jia Zhiye Du Baotong Zhang Siyuan Xia |
| author_facet | Jiali Xu Houde Zhang Zhihao Nie Wenyou He Yichao Zhao Zhenhui Huang Lin Jia Zhiye Du Baotong Zhang Siyuan Xia |
| author_sort | Jiali Xu |
| collection | DOAJ |
| description | Cell plasticity emerges as a novel cancer hallmark and is pivotal in driving tumor heterogeneity and adaptive resistance to different therapies. Cancer stem-like cells (CSCs) are considered the root of cancer. While first defined as tumor-initiating cells with the potential to develop a heterogeneous tumor, CSCs further demonstrate their roles in cancer metastasis and adaptive therapeutic resistance. Generally, CSCs come from the malignant transformation of somatic stem cells or the de-differentiation of other cancer cells. The resultant cells gain more plasticity and are ready to differentiate into different cell states, enabling them to adapt to therapies and metastatic ecosystems. Therefore, CSCs are likely the nature of tumor cells that gain cell plasticity. However, the phenotypic plasticity of CSCs has never been systematically discussed. Here, we review the distinct intrinsic signaling pathways and unique microenvironmental niches that endow CSC plasticity in solid tumors to adapt to stressful conditions, as well as emerging opportunities for CSC-targeted therapy. |
| format | Article |
| id | doaj-art-4990faa3b57c46db90c8532d606ac503 |
| institution | Kabale University |
| issn | 1476-5586 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj-art-4990faa3b57c46db90c8532d606ac5032025-02-08T04:59:59ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862025-03-0161101134Cancer stem-like cells stay in a plastic state ready for tumor evolutionJiali Xu0Houde Zhang1Zhihao Nie2Wenyou He3Yichao Zhao4Zhenhui Huang5Lin Jia6Zhiye Du7Baotong Zhang8Siyuan Xia9Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaCoulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USACollege of Pharmacy, Shenzhen Technology University, Shenzhen 518118, Guangdong, ChinaCollege of Pharmacy, Shenzhen Technology University, Shenzhen 518118, Guangdong, China; Corresponding authors.Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, China; Corresponding authors.Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China; Corresponding authors.Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China; Corresponding authors.Cell plasticity emerges as a novel cancer hallmark and is pivotal in driving tumor heterogeneity and adaptive resistance to different therapies. Cancer stem-like cells (CSCs) are considered the root of cancer. While first defined as tumor-initiating cells with the potential to develop a heterogeneous tumor, CSCs further demonstrate their roles in cancer metastasis and adaptive therapeutic resistance. Generally, CSCs come from the malignant transformation of somatic stem cells or the de-differentiation of other cancer cells. The resultant cells gain more plasticity and are ready to differentiate into different cell states, enabling them to adapt to therapies and metastatic ecosystems. Therefore, CSCs are likely the nature of tumor cells that gain cell plasticity. However, the phenotypic plasticity of CSCs has never been systematically discussed. Here, we review the distinct intrinsic signaling pathways and unique microenvironmental niches that endow CSC plasticity in solid tumors to adapt to stressful conditions, as well as emerging opportunities for CSC-targeted therapy.http://www.sciencedirect.com/science/article/pii/S1476558625000132Cell plasticityCancer stem-like cell (CSC)Tumor heterogeneityTherapeutic resistanceCancer metastasisChemotherapy |
| spellingShingle | Jiali Xu Houde Zhang Zhihao Nie Wenyou He Yichao Zhao Zhenhui Huang Lin Jia Zhiye Du Baotong Zhang Siyuan Xia Cancer stem-like cells stay in a plastic state ready for tumor evolution Neoplasia: An International Journal for Oncology Research Cell plasticity Cancer stem-like cell (CSC) Tumor heterogeneity Therapeutic resistance Cancer metastasis Chemotherapy |
| title | Cancer stem-like cells stay in a plastic state ready for tumor evolution |
| title_full | Cancer stem-like cells stay in a plastic state ready for tumor evolution |
| title_fullStr | Cancer stem-like cells stay in a plastic state ready for tumor evolution |
| title_full_unstemmed | Cancer stem-like cells stay in a plastic state ready for tumor evolution |
| title_short | Cancer stem-like cells stay in a plastic state ready for tumor evolution |
| title_sort | cancer stem like cells stay in a plastic state ready for tumor evolution |
| topic | Cell plasticity Cancer stem-like cell (CSC) Tumor heterogeneity Therapeutic resistance Cancer metastasis Chemotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S1476558625000132 |
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