COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution Exposure
Abstract Chronic obstructive pulmonary disease (COPD) has been linked to air pollution exposure. Air pollution has been associated with eosinophilic inflammation of respiratory disease. The objective of this study was to determine associations between air pollution and eosinophilic inflammation in C...
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| Format: | Article |
| Language: | English |
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Springer
2023-05-01
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| Series: | Aerosol and Air Quality Research |
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| Online Access: | https://doi.org/10.4209/aaqr.230035 |
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| author | Amja Manullang Chi-Li Chung Yueh-Lun Lee Tzu-Hsuen Yuan Huan Minh Tran Firdian Makrufardi Kian Fan Chung Kang-Yun Lee Jer-Hwa Chang Hsiao-Chi Chuang |
| author_facet | Amja Manullang Chi-Li Chung Yueh-Lun Lee Tzu-Hsuen Yuan Huan Minh Tran Firdian Makrufardi Kian Fan Chung Kang-Yun Lee Jer-Hwa Chang Hsiao-Chi Chuang |
| author_sort | Amja Manullang |
| collection | DOAJ |
| description | Abstract Chronic obstructive pulmonary disease (COPD) has been linked to air pollution exposure. Air pollution has been associated with eosinophilic inflammation of respiratory disease. The objective of this study was to determine associations between air pollution and eosinophilic inflammation in COPD. A cross-sectional study was conducted on 291 COPD patients recruited from hospitals in Taipei between January 2014 and 2021, including 147 patients with eosinophil blood count ≥ 2% and 144 patients < 2%. Land use regression (LUR) model was used to estimate exposure levels to particulate matter with an aerodynamic diameter of < 10 µm (PM10), PM2.5 (< 10 µm), nitrogen oxides (NOx) and nitrogen dioxides (NO2). We investigated associations of air pollution with COPD outcomes by performing a linear regression approach. A two-pollutant approach was applied to examine the associations of PM10 or PM2.5 with NOx or NO2 in COPD with eosinophilic inflammation. An increase of 1 µg m−3 in PM10 was associated with a 0.62% (95% CI: −1.10%, −0.13%) decrease in the forced vital capacity (FVC) in COPD. An increase of 1 µg m−3 in PM2.5 was associated with a 0.38% (95% CI: −0.71%, −0.05%) decrease in the FVC. A 1 µg m−3 increase in PM10 was associated with a 0.92% (95% CI: −1.68%, −0.16%) decrease in the FVC in COPD patients with eosinophilic inflammation. A 1 µg m−3 increase in PM2.5 was associated with an increase of 0.26 points (95% CI: −1.68%, −0.16%) in the COPD Assessment Test (CAT) and a 0.03-times year−1 (95% CI: 0.01, 0.05) increase in the acute exacerbation (AE) of COPD eosinophilic inflammation. Associations of PM10 and PM2.5 with lung function decline in COPD eosinophilic inflammation were confirmed by the two-pollutant model. Exposure to particulate air pollution increased the risk of deleterious health outcomes in COPD with eosinophilic inflammation. COPD with eosinophilic inflammation may represent a susceptible group to particulate air pollution exposure. |
| format | Article |
| id | doaj-art-4a5aa14298844c09a54526dfb09f37f6 |
| institution | Kabale University |
| issn | 1680-8584 2071-1409 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Aerosol and Air Quality Research |
| spelling | doaj-art-4a5aa14298844c09a54526dfb09f37f62025-02-09T12:23:01ZengSpringerAerosol and Air Quality Research1680-85842071-14092023-05-0123811410.4209/aaqr.230035COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution ExposureAmja Manullang0Chi-Li Chung1Yueh-Lun Lee2Tzu-Hsuen Yuan3Huan Minh Tran4Firdian Makrufardi5Kian Fan Chung6Kang-Yun Lee7Jer-Hwa Chang8Hsiao-Chi Chuang9International Ph.D. Program in Medicine, College of Medicine, Taipei Medical UniversitySchool of Respiratory Therapy, College of Medicine, Taipei Medical UniversityDepartment of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical UniversityDepartment of Health and Welfare, College of City Management, University of TaipeiPh.D. Program in Global Health and Health Security, College of Public Health, Taipei Medical UniversityInternational Ph.D. Program in Medicine, College of Medicine, Taipei Medical UniversityNational Heart and Lung Institute, Imperial College LondonDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical UniversitySchool of Respiratory Therapy, College of Medicine, Taipei Medical UniversitySchool of Respiratory Therapy, College of Medicine, Taipei Medical UniversityAbstract Chronic obstructive pulmonary disease (COPD) has been linked to air pollution exposure. Air pollution has been associated with eosinophilic inflammation of respiratory disease. The objective of this study was to determine associations between air pollution and eosinophilic inflammation in COPD. A cross-sectional study was conducted on 291 COPD patients recruited from hospitals in Taipei between January 2014 and 2021, including 147 patients with eosinophil blood count ≥ 2% and 144 patients < 2%. Land use regression (LUR) model was used to estimate exposure levels to particulate matter with an aerodynamic diameter of < 10 µm (PM10), PM2.5 (< 10 µm), nitrogen oxides (NOx) and nitrogen dioxides (NO2). We investigated associations of air pollution with COPD outcomes by performing a linear regression approach. A two-pollutant approach was applied to examine the associations of PM10 or PM2.5 with NOx or NO2 in COPD with eosinophilic inflammation. An increase of 1 µg m−3 in PM10 was associated with a 0.62% (95% CI: −1.10%, −0.13%) decrease in the forced vital capacity (FVC) in COPD. An increase of 1 µg m−3 in PM2.5 was associated with a 0.38% (95% CI: −0.71%, −0.05%) decrease in the FVC. A 1 µg m−3 increase in PM10 was associated with a 0.92% (95% CI: −1.68%, −0.16%) decrease in the FVC in COPD patients with eosinophilic inflammation. A 1 µg m−3 increase in PM2.5 was associated with an increase of 0.26 points (95% CI: −1.68%, −0.16%) in the COPD Assessment Test (CAT) and a 0.03-times year−1 (95% CI: 0.01, 0.05) increase in the acute exacerbation (AE) of COPD eosinophilic inflammation. Associations of PM10 and PM2.5 with lung function decline in COPD eosinophilic inflammation were confirmed by the two-pollutant model. Exposure to particulate air pollution increased the risk of deleterious health outcomes in COPD with eosinophilic inflammation. COPD with eosinophilic inflammation may represent a susceptible group to particulate air pollution exposure.https://doi.org/10.4209/aaqr.230035Acute exacerbationAir pollutionLung functionPM10PM2.5 |
| spellingShingle | Amja Manullang Chi-Li Chung Yueh-Lun Lee Tzu-Hsuen Yuan Huan Minh Tran Firdian Makrufardi Kian Fan Chung Kang-Yun Lee Jer-Hwa Chang Hsiao-Chi Chuang COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution Exposure Aerosol and Air Quality Research Acute exacerbation Air pollution Lung function PM10 PM2.5 |
| title | COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution Exposure |
| title_full | COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution Exposure |
| title_fullStr | COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution Exposure |
| title_full_unstemmed | COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution Exposure |
| title_short | COPD with Eosinophilic Inflammation is Susceptible to Particulate Air Pollution Exposure |
| title_sort | copd with eosinophilic inflammation is susceptible to particulate air pollution exposure |
| topic | Acute exacerbation Air pollution Lung function PM10 PM2.5 |
| url | https://doi.org/10.4209/aaqr.230035 |
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