Dynamic monocyte changes as prognostic indicators in operable gastric cancer: a retrospective cohort analysis
ObjectiveThis study aims to elucidate the relationship between postoperative monocyte count and gastric cancer prognosis. We introduce a standardized monocyte ratio (MMR) to predict postoperative survival rates in gastric cancer patients effectively.MethodsA test cohort was created to develop and ev...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1514281/full |
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| author | Yiwei Jiang Xianwei Sun Chen Yang Dandan Song Chongjun Zhou Xinxin Chen Chongquan Huang Zhonglin Wang Jiante Li |
| author_facet | Yiwei Jiang Xianwei Sun Chen Yang Dandan Song Chongjun Zhou Xinxin Chen Chongquan Huang Zhonglin Wang Jiante Li |
| author_sort | Yiwei Jiang |
| collection | DOAJ |
| description | ObjectiveThis study aims to elucidate the relationship between postoperative monocyte count and gastric cancer prognosis. We introduce a standardized monocyte ratio (MMR) to predict postoperative survival rates in gastric cancer patients effectively.MethodsA test cohort was created to develop and evaluate the pre- and postoperative MMR as a mortality predictor in gastric cancer patients. We used Kaplan-Meier survival analysis, complemented by univariate and multivariate analyses. The predictive utility of MMR was assessed via time-dependent ROC curves and decision-curve analysis.ResultsThe sample distributions in both cohorts were similar. The MMR showed high predictive value and significant clinical benefits in 1, 3, and 5-year overall survival (OS) assessments. These findings enhance understanding of prognosis and aid in developing more precise treatment plans.ConclusionsMMR is confirmed as an independent factor in predicting overall survival in gastric cancer patients, proving to be a reliable and cost-effective prognostic indicator. |
| format | Article |
| id | doaj-art-4a99e40efd454a0c83136643fdf2587b |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-4a99e40efd454a0c83136643fdf2587b2025-02-07T05:10:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15142811514281Dynamic monocyte changes as prognostic indicators in operable gastric cancer: a retrospective cohort analysisYiwei Jiang0Xianwei Sun1Chen Yang2Dandan Song3Chongjun Zhou4Xinxin Chen5Chongquan Huang6Zhonglin Wang7Jiante Li8Department of Gastrointestinal Surgery, The 2nd Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, The 1st Affiliated Hospital Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Anorectal Surgery, The 2nd Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Anorectal Surgery, The 2nd Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Anorectal Surgery, The 2nd Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Gastrointestinal Surgery, The 2nd Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Radioimaging, Wenzhou Central Hospital, Wenzhou, Zhejiang, ChinaDepartment of Anorectal Surgery, The 2nd Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaDepartment of Anorectal Surgery, The 2nd Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, ChinaObjectiveThis study aims to elucidate the relationship between postoperative monocyte count and gastric cancer prognosis. We introduce a standardized monocyte ratio (MMR) to predict postoperative survival rates in gastric cancer patients effectively.MethodsA test cohort was created to develop and evaluate the pre- and postoperative MMR as a mortality predictor in gastric cancer patients. We used Kaplan-Meier survival analysis, complemented by univariate and multivariate analyses. The predictive utility of MMR was assessed via time-dependent ROC curves and decision-curve analysis.ResultsThe sample distributions in both cohorts were similar. The MMR showed high predictive value and significant clinical benefits in 1, 3, and 5-year overall survival (OS) assessments. These findings enhance understanding of prognosis and aid in developing more precise treatment plans.ConclusionsMMR is confirmed as an independent factor in predicting overall survival in gastric cancer patients, proving to be a reliable and cost-effective prognostic indicator.https://www.frontiersin.org/articles/10.3389/fonc.2025.1514281/fullgastric cancerpostoperative and preoperative monocytes ratioprognosisoverall survival (OS)precise treatment |
| spellingShingle | Yiwei Jiang Xianwei Sun Chen Yang Dandan Song Chongjun Zhou Xinxin Chen Chongquan Huang Zhonglin Wang Jiante Li Dynamic monocyte changes as prognostic indicators in operable gastric cancer: a retrospective cohort analysis Frontiers in Oncology gastric cancer postoperative and preoperative monocytes ratio prognosis overall survival (OS) precise treatment |
| title | Dynamic monocyte changes as prognostic indicators in operable gastric cancer: a retrospective cohort analysis |
| title_full | Dynamic monocyte changes as prognostic indicators in operable gastric cancer: a retrospective cohort analysis |
| title_fullStr | Dynamic monocyte changes as prognostic indicators in operable gastric cancer: a retrospective cohort analysis |
| title_full_unstemmed | Dynamic monocyte changes as prognostic indicators in operable gastric cancer: a retrospective cohort analysis |
| title_short | Dynamic monocyte changes as prognostic indicators in operable gastric cancer: a retrospective cohort analysis |
| title_sort | dynamic monocyte changes as prognostic indicators in operable gastric cancer a retrospective cohort analysis |
| topic | gastric cancer postoperative and preoperative monocytes ratio prognosis overall survival (OS) precise treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1514281/full |
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