Phenotype control and elimination of variables in Boolean networks
We investigate how elimination of variables can affect the asymptotic dynamics and phenotype control of Boolean networks. In particular, we look at the impact on minimal trap spaces, and identify a structural condition that guarantees their preservation. We examine the possible effects of variable e...
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| Format: | Article |
| Language: | English |
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2024-08-01
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| Series: | Peer Community Journal |
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| Online Access: | https://peercommunityjournal.org/articles/10.24072/pcjournal.452/ |
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| author | Tonello, Elisa Paulevé, Loïc |
| author_facet | Tonello, Elisa Paulevé, Loïc |
| author_sort | Tonello, Elisa |
| collection | DOAJ |
| description | We investigate how elimination of variables can affect the asymptotic dynamics and phenotype control of Boolean networks. In particular, we look at the impact on minimal trap spaces, and identify a structural condition that guarantees their preservation. We examine the possible effects of variable elimination under three of the most popular approaches to control (attractor-based control, value propagation and control of minimal trap spaces), and under different update schemes (synchronous, asynchronous, generalized asynchronous). We provide some insights on the application of reduction, and an ample inventory of examples and counterexamples. |
| format | Article |
| id | doaj-art-4c715f54a0a5442b83f70ac453430167 |
| institution | Kabale University |
| issn | 2804-3871 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Peer Community In |
| record_format | Article |
| series | Peer Community Journal |
| spelling | doaj-art-4c715f54a0a5442b83f70ac4534301672025-02-07T10:17:18ZengPeer Community InPeer Community Journal2804-38712024-08-01410.24072/pcjournal.45210.24072/pcjournal.452Phenotype control and elimination of variables in Boolean networks Tonello, Elisa0https://orcid.org/0000-0002-5182-4216Paulevé, Loïc1https://orcid.org/0000-0002-7219-2027Department of Mathematics and Computer Science, Freie Universität Berlin, GermanyUniv. Bordeaux, CNRS, Bordeaux INP, LaBRI, UMR 5800, F-33400 Talence, FranceWe investigate how elimination of variables can affect the asymptotic dynamics and phenotype control of Boolean networks. In particular, we look at the impact on minimal trap spaces, and identify a structural condition that guarantees their preservation. We examine the possible effects of variable elimination under three of the most popular approaches to control (attractor-based control, value propagation and control of minimal trap spaces), and under different update schemes (synchronous, asynchronous, generalized asynchronous). We provide some insights on the application of reduction, and an ample inventory of examples and counterexamples.https://peercommunityjournal.org/articles/10.24072/pcjournal.452/Boolean networks, control, reduction, trap spaces |
| spellingShingle | Tonello, Elisa Paulevé, Loïc Phenotype control and elimination of variables in Boolean networks Peer Community Journal Boolean networks, control, reduction, trap spaces |
| title | Phenotype control and elimination of variables in Boolean networks
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| title_full | Phenotype control and elimination of variables in Boolean networks
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| title_fullStr | Phenotype control and elimination of variables in Boolean networks
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| title_full_unstemmed | Phenotype control and elimination of variables in Boolean networks
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| title_short | Phenotype control and elimination of variables in Boolean networks
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| title_sort | phenotype control and elimination of variables in boolean networks |
| topic | Boolean networks, control, reduction, trap spaces |
| url | https://peercommunityjournal.org/articles/10.24072/pcjournal.452/ |
| work_keys_str_mv | AT tonelloelisa phenotypecontrolandeliminationofvariablesinbooleannetworks AT pauleveloic phenotypecontrolandeliminationofvariablesinbooleannetworks |