Antimicrobial drug use and its association with antimicrobial resistance in fecal commensals from cows on California dairies
The current study objective was to investigate the risk factors associated with the isolation of antimicrobial-resistant Escherichia coli, Enterococcus spp., and Streptococcus spp. (ES) from the feces of dairy cows in California (CA). A longitudinal study was conducted on ten dairies, and a random s...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1504640/full |
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| author | Essam M. Abdelfattah Essam M. Abdelfattah Pius S. Ekong Emmanuel Okello Emmanuel Okello Tapakorn Chamchoy Betsy M. Karle Randi A. Black Wagdy ElAshmawy Wagdy ElAshmawy David Sheedy Deniece R. Williams Terry W. Lehenbauer Terry W. Lehenbauer Barbara A. Byrne Sharif S. Aly Sharif S. Aly |
| author_facet | Essam M. Abdelfattah Essam M. Abdelfattah Pius S. Ekong Emmanuel Okello Emmanuel Okello Tapakorn Chamchoy Betsy M. Karle Randi A. Black Wagdy ElAshmawy Wagdy ElAshmawy David Sheedy Deniece R. Williams Terry W. Lehenbauer Terry W. Lehenbauer Barbara A. Byrne Sharif S. Aly Sharif S. Aly |
| author_sort | Essam M. Abdelfattah |
| collection | DOAJ |
| description | The current study objective was to investigate the risk factors associated with the isolation of antimicrobial-resistant Escherichia coli, Enterococcus spp., and Streptococcus spp. (ES) from the feces of dairy cows in California (CA). A longitudinal study was conducted on ten dairies, and a random sample of cattle (late pregnant heifers and dry cows) stratified by each herd’s parity distribution were followed monthly from close-up to 120 days in milk during fall to winter 2018 (winter season) and spring to summer 2019 (summer season). Gastrointestinal commensals were isolated from fecal samples and tested for antimicrobial susceptibility using the broth microdilution method against a selected panel of antimicrobial drugs (AMD). Eight dairies used blanket AMD therapy at dry-off for all lactating cows, while the remaining two dairies did not use any AMD treatment at dry-off. Clinical mastitis was identified as the most common indication for AMD use across the study dairies. Intramuscular administration of ceftiofur hydrochloride to treat lameness and unknown disease during lactation was significantly associated with the isolation of tetracycline-resistant fecal E. coli. Resistance to ceftiofur, tetracycline, or trimethoprim-sulfamethoxazole in fecal E. coli was significantly higher in the winter than in the summer season. In contrast, resistance to tetracycline, florfenicol, tilmicosin, tildipirosin, or tiamulin in fecal gram-positive commensals was significantly higher in the summer than in the winter. In conclusion, AMD usage practices and seasonal variations significantly influenced the AMR of E. coli and ES in the feces of dairy cattle. |
| format | Article |
| id | doaj-art-4c84198ea0c747e2b99a6f52e1567dca |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-4c84198ea0c747e2b99a6f52e1567dca2025-02-10T13:38:09ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-02-011110.3389/fvets.2024.15046401504640Antimicrobial drug use and its association with antimicrobial resistance in fecal commensals from cows on California dairiesEssam M. Abdelfattah0Essam M. Abdelfattah1Pius S. Ekong2Emmanuel Okello3Emmanuel Okello4Tapakorn Chamchoy5Betsy M. Karle6Randi A. Black7Wagdy ElAshmawy8Wagdy ElAshmawy9David Sheedy10Deniece R. Williams11Terry W. Lehenbauer12Terry W. Lehenbauer13Barbara A. Byrne14Sharif S. Aly15Sharif S. Aly16Veterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California, Davis, Tulare, CA, United StatesDepartment of Animal Hygiene and Veterinary Management, Faculty of Veterinary Medicine, Benha University, Al Qalyubiyah, EgyptVeterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California, Davis, Tulare, CA, United StatesVeterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California, Davis, Tulare, CA, United StatesDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, CA, United StatesVeterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California, Davis, Tulare, CA, United StatesCooperative Extension, Division of Agriculture and Natural Resources, University of California, Orland, CA, United StatesCooperative Extension, Division of Agriculture and Natural Resources, University of California, Santa Rosa, CA, United StatesVeterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California, Davis, Tulare, CA, United StatesDepartment of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, EgyptVeterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California, Davis, Tulare, CA, United StatesVeterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California, Davis, Tulare, CA, United StatesVeterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California, Davis, Tulare, CA, United StatesDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, CA, United StatesDepartment of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA, United StatesVeterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California, Davis, Tulare, CA, United StatesDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, CA, United StatesThe current study objective was to investigate the risk factors associated with the isolation of antimicrobial-resistant Escherichia coli, Enterococcus spp., and Streptococcus spp. (ES) from the feces of dairy cows in California (CA). A longitudinal study was conducted on ten dairies, and a random sample of cattle (late pregnant heifers and dry cows) stratified by each herd’s parity distribution were followed monthly from close-up to 120 days in milk during fall to winter 2018 (winter season) and spring to summer 2019 (summer season). Gastrointestinal commensals were isolated from fecal samples and tested for antimicrobial susceptibility using the broth microdilution method against a selected panel of antimicrobial drugs (AMD). Eight dairies used blanket AMD therapy at dry-off for all lactating cows, while the remaining two dairies did not use any AMD treatment at dry-off. Clinical mastitis was identified as the most common indication for AMD use across the study dairies. Intramuscular administration of ceftiofur hydrochloride to treat lameness and unknown disease during lactation was significantly associated with the isolation of tetracycline-resistant fecal E. coli. Resistance to ceftiofur, tetracycline, or trimethoprim-sulfamethoxazole in fecal E. coli was significantly higher in the winter than in the summer season. In contrast, resistance to tetracycline, florfenicol, tilmicosin, tildipirosin, or tiamulin in fecal gram-positive commensals was significantly higher in the summer than in the winter. In conclusion, AMD usage practices and seasonal variations significantly influenced the AMR of E. coli and ES in the feces of dairy cattle.https://www.frontiersin.org/articles/10.3389/fvets.2024.1504640/fullantimicrobial resistanceantimicrobial drug useantibioticsdairy cowsCaliforniaseason |
| spellingShingle | Essam M. Abdelfattah Essam M. Abdelfattah Pius S. Ekong Emmanuel Okello Emmanuel Okello Tapakorn Chamchoy Betsy M. Karle Randi A. Black Wagdy ElAshmawy Wagdy ElAshmawy David Sheedy Deniece R. Williams Terry W. Lehenbauer Terry W. Lehenbauer Barbara A. Byrne Sharif S. Aly Sharif S. Aly Antimicrobial drug use and its association with antimicrobial resistance in fecal commensals from cows on California dairies Frontiers in Veterinary Science antimicrobial resistance antimicrobial drug use antibiotics dairy cows California season |
| title | Antimicrobial drug use and its association with antimicrobial resistance in fecal commensals from cows on California dairies |
| title_full | Antimicrobial drug use and its association with antimicrobial resistance in fecal commensals from cows on California dairies |
| title_fullStr | Antimicrobial drug use and its association with antimicrobial resistance in fecal commensals from cows on California dairies |
| title_full_unstemmed | Antimicrobial drug use and its association with antimicrobial resistance in fecal commensals from cows on California dairies |
| title_short | Antimicrobial drug use and its association with antimicrobial resistance in fecal commensals from cows on California dairies |
| title_sort | antimicrobial drug use and its association with antimicrobial resistance in fecal commensals from cows on california dairies |
| topic | antimicrobial resistance antimicrobial drug use antibiotics dairy cows California season |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1504640/full |
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