Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis
Epithelial barriers serve as critical defense lines against microbial infiltration and maintain tissue homeostasis. E-cadherin, an essential component of adherens junctions, has emerged as a pivotal molecule that secures epithelial homeostasis. Lately, its pleiotropic role beyond barrier function, i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1506636/full |
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| author | Peter Lialios Peter Lialios Stella Alimperti Stella Alimperti |
| author_facet | Peter Lialios Peter Lialios Stella Alimperti Stella Alimperti |
| author_sort | Peter Lialios |
| collection | DOAJ |
| description | Epithelial barriers serve as critical defense lines against microbial infiltration and maintain tissue homeostasis. E-cadherin, an essential component of adherens junctions, has emerged as a pivotal molecule that secures epithelial homeostasis. Lately, its pleiotropic role beyond barrier function, including its involvement in immune responses, has become more evident. Herein, we delve into the intricate relationship between (dys)regulation of epithelial homeostasis and the versatile functionality of E-cadherin, describing complex mechanisms that underlie barrier integrity and disruption in disease pathogenesis such as bacterial infection and inflammation, among others. Clinical implications of E-cadherin perturbations in host pathophysiology are emphasized; downregulation, proteolytic phenomena, abnormal localization/signaling and aberrant immune reactions are linked with a broad spectrum of pathology beyond infectious diseases. Finally, potential therapeutic interventions that may harness E-cadherin to mitigate barrier-associated tissue damage are explored. Overall, this review highlights the crucial role of E-cadherin in systemic health, offering insights that could pave the way for strategies to reinforce/restore barrier integrity and treat related diseases. |
| format | Article |
| id | doaj-art-4c9f28996c32433e87c74da46822619b |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-4c9f28996c32433e87c74da46822619b2025-02-11T06:59:25ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-02-011510.3389/fcimb.2025.15066361506636Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesisPeter Lialios0Peter Lialios1Stella Alimperti2Stella Alimperti3Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, United StatesCenter for Biological and Biomedical Engineering, Georgetown University, Washington, DC, United StatesDepartment of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, United StatesCenter for Biological and Biomedical Engineering, Georgetown University, Washington, DC, United StatesEpithelial barriers serve as critical defense lines against microbial infiltration and maintain tissue homeostasis. E-cadherin, an essential component of adherens junctions, has emerged as a pivotal molecule that secures epithelial homeostasis. Lately, its pleiotropic role beyond barrier function, including its involvement in immune responses, has become more evident. Herein, we delve into the intricate relationship between (dys)regulation of epithelial homeostasis and the versatile functionality of E-cadherin, describing complex mechanisms that underlie barrier integrity and disruption in disease pathogenesis such as bacterial infection and inflammation, among others. Clinical implications of E-cadherin perturbations in host pathophysiology are emphasized; downregulation, proteolytic phenomena, abnormal localization/signaling and aberrant immune reactions are linked with a broad spectrum of pathology beyond infectious diseases. Finally, potential therapeutic interventions that may harness E-cadherin to mitigate barrier-associated tissue damage are explored. Overall, this review highlights the crucial role of E-cadherin in systemic health, offering insights that could pave the way for strategies to reinforce/restore barrier integrity and treat related diseases.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1506636/fullE-cadherinepithelial barrierinfectionbacteriainflammationhomeostasis |
| spellingShingle | Peter Lialios Peter Lialios Stella Alimperti Stella Alimperti Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis Frontiers in Cellular and Infection Microbiology E-cadherin epithelial barrier infection bacteria inflammation homeostasis |
| title | Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis |
| title_full | Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis |
| title_fullStr | Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis |
| title_full_unstemmed | Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis |
| title_short | Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis |
| title_sort | role of e cadherin in epithelial barrier dysfunction implications for bacterial infection inflammation and disease pathogenesis |
| topic | E-cadherin epithelial barrier infection bacteria inflammation homeostasis |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1506636/full |
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