Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT)
Real-world data on gender differences in quality of life among psoriasis patients before and during treatment are scarce. This study analysed data of 748 adults with moderate-to-severe psoriasis enrolled in the Swiss Dermatology Network of Targeted Therapy registry between 2011 and 2023. Quality of...
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Medical Journals Sweden
2025-02-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: | https://medicaljournalssweden.se/actadv/article/view/42296 |
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| author | Ramtin Lichtenberger Lara Valeska Maul Ion Birkenmaier Iker Oyanguren Melike Ak Kristine Heidemeyer Christoph Schlapbach Nikhil Yawalkar Alexander Egeberg Simon Francis Thomsen Jacob P. Thyssen Christina Sorbe Wolf-Henning Boehncke Curdin Conrad Antonio Cozzio Georgios Kokolakis Raphael Micheroli Jashin J. Wu Thomas Kündig Alexander Navarini Julia-Tatjana Maul |
| author_facet | Ramtin Lichtenberger Lara Valeska Maul Ion Birkenmaier Iker Oyanguren Melike Ak Kristine Heidemeyer Christoph Schlapbach Nikhil Yawalkar Alexander Egeberg Simon Francis Thomsen Jacob P. Thyssen Christina Sorbe Wolf-Henning Boehncke Curdin Conrad Antonio Cozzio Georgios Kokolakis Raphael Micheroli Jashin J. Wu Thomas Kündig Alexander Navarini Julia-Tatjana Maul |
| author_sort | Ramtin Lichtenberger |
| collection | DOAJ |
| description | Real-world data on gender differences in quality of life among psoriasis patients before and during treatment are scarce. This study analysed data of 748 adults with moderate-to-severe psoriasis enrolled in the Swiss Dermatology Network of Targeted Therapy registry between 2011 and 2023. Quality of life was assessed using the Dermatological Life Quality Index at baseline and at 3, 6, 12, 18, and 24 months. At baseline, women reported significantly lower quality of life than men, with higher Dermatological Life Quality Index scores in the IL-17 inhibitor group (15.0 vs 11.0, p = 0.027), IL-12/23 inhibitor group (7.5 vs 7.0, p = 0.049), and non-biologic therapy group (13.0 vs 9.0, p < 0.001). Although quality of life improved across all subgroups during the follow-up period, women treated with IL-12/23 inhibitors continued to report worse quality of life compared with men after 2 years (p < 0.05), while no significant differences were observed with other therapies. These findings emphasize that women with psoriasis experience lower quality of life at treatment initiation and throughout non-biologic and biologic therapies, underlining the importance of addressing gender-specific differences in the management of psoriasis.
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| format | Article |
| id | doaj-art-4dae8fe6b4744314a89f03d5dee171eb |
| institution | Kabale University |
| issn | 0001-5555 1651-2057 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj-art-4dae8fe6b4744314a89f03d5dee171eb2025-02-07T07:50:51ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572025-02-0110510.2340/actadv.v105.42296Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT)Ramtin Lichtenberger0https://orcid.org/0000-0002-7682-0238Lara Valeska Maul1Ion Birkenmaier2Iker Oyanguren3Melike Ak4Kristine Heidemeyer5Christoph Schlapbach6Nikhil Yawalkar7Alexander Egeberg8Simon Francis Thomsen9Jacob P. Thyssen10Christina Sorbe11Wolf-Henning Boehncke12Curdin Conrad13Antonio Cozzio14Georgios Kokolakis15Raphael Micheroli16Jashin J. Wu17Thomas Kündig18Alexander Navarini19Julia-Tatjana Maul20Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.Department of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, SwitzerlandDepartment of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland; Life Science Zurich Graduate School, Faculty of Science, University of Zurich, Zurich, SwitzerlandSwiss4ward, Statistician and Data Analyst, Zurich, SwitzerlandDepartment of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, SwitzerlandDepartment of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Dermato-Venereology & Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Dermato-Venereology & Wound Healing Centre, Bispebjerg Hospital, Copenhagen, DenmarkDepartment of Dermato-Venereology & Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkInstitute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, GermanyDivision of Dermatology and Venereology, Geneva University Hospitals, Geneva, SwitzerlandDepartment of Dermatology, University Hospital Lausanne, Lausanne, SwitzerlandDepartment of Dermatology, Cantonal Hospital St. Gallen, St. Gallen, SwitzerlandPsoriasis Research and Treatment Center, Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandDepartment of Dermatology, University of Miami Miller School of Medicine, Miami, USADepartment of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland; Faculty of Medicine, University of Zurich, Zurich, SwitzerlandDepartment of Dermatology, University Hospital Basel, University of Basel, Basel, SwitzerlandDepartment of Dermatology, University Hospital of Zurich, University of Zurich, Zurich, Switzerland; Faculty of Medicine, University of Zurich, Zurich, SwitzerlandReal-world data on gender differences in quality of life among psoriasis patients before and during treatment are scarce. This study analysed data of 748 adults with moderate-to-severe psoriasis enrolled in the Swiss Dermatology Network of Targeted Therapy registry between 2011 and 2023. Quality of life was assessed using the Dermatological Life Quality Index at baseline and at 3, 6, 12, 18, and 24 months. At baseline, women reported significantly lower quality of life than men, with higher Dermatological Life Quality Index scores in the IL-17 inhibitor group (15.0 vs 11.0, p = 0.027), IL-12/23 inhibitor group (7.5 vs 7.0, p = 0.049), and non-biologic therapy group (13.0 vs 9.0, p < 0.001). Although quality of life improved across all subgroups during the follow-up period, women treated with IL-12/23 inhibitors continued to report worse quality of life compared with men after 2 years (p < 0.05), while no significant differences were observed with other therapies. These findings emphasize that women with psoriasis experience lower quality of life at treatment initiation and throughout non-biologic and biologic therapies, underlining the importance of addressing gender-specific differences in the management of psoriasis. https://medicaljournalssweden.se/actadv/article/view/42296Dermatology Life Quality Index (DLQI)patient-reported outcome measure (PROM)psoriasis vulgarisregistrySDNTTsex differences |
| spellingShingle | Ramtin Lichtenberger Lara Valeska Maul Ion Birkenmaier Iker Oyanguren Melike Ak Kristine Heidemeyer Christoph Schlapbach Nikhil Yawalkar Alexander Egeberg Simon Francis Thomsen Jacob P. Thyssen Christina Sorbe Wolf-Henning Boehncke Curdin Conrad Antonio Cozzio Georgios Kokolakis Raphael Micheroli Jashin J. Wu Thomas Kündig Alexander Navarini Julia-Tatjana Maul Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT) Acta Dermato-Venereologica Dermatology Life Quality Index (DLQI) patient-reported outcome measure (PROM) psoriasis vulgaris registry SDNTT sex differences |
| title | Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT) |
| title_full | Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT) |
| title_fullStr | Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT) |
| title_full_unstemmed | Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT) |
| title_short | Sex Disparities of Health-related Quality of Life in Moderate to Severe Psoriasis: A Real-world Analysis from the Swiss Psoriasis Registry (SDNTT) |
| title_sort | sex disparities of health related quality of life in moderate to severe psoriasis a real world analysis from the swiss psoriasis registry sdntt |
| topic | Dermatology Life Quality Index (DLQI) patient-reported outcome measure (PROM) psoriasis vulgaris registry SDNTT sex differences |
| url | https://medicaljournalssweden.se/actadv/article/view/42296 |
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