Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia

Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia

Abstract Background Significant sex differences exist in the prevalence and incidence of Alzheimer’s disease (AD). Notably, testosterone has been reported to regulate cognitive functions in the brain, with low serum testosterone levels correlating with increased AD risk. However, the specific mechan...

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Main Authors: Haolin Zheng, Akiko Mizokami, Sergio Romera-Giner, Jaime Llera-Oyola, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Francisco García-García, Takashi Kanematsu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Biology of Sex Differences
Subjects:
Fatty acid synthesis
Inflammation
Microglia
miRNA
Sex differences
Testosterone
Online Access:https://doi.org/10.1186/s13293-025-00686-8
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