Exposure to nano-polystyrene during pregnancy leads to Alzheimer's disease-related pathological changes in adult offspring
Nanoplastics are common environmental pollutants. As of now, research has yet to explore how exposure to nanomaterials during gestation might influence the risk of developing Alzheimer's disease (AD) in offspring. Throughout the research, we assessed the AD pathology in adult offspring of mice...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000727 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856897061552128 |
|---|---|
| author | Fengxu Wang Jin Wang Na Luo Yonghua Luo Zhengnan Gao Ye Cui Mengna Jiang Zhaoping Shen Jing Xiao Peng Xue Xiaoke Wang Shali Yu Qiyun Wu Xinyuan Zhao |
| author_facet | Fengxu Wang Jin Wang Na Luo Yonghua Luo Zhengnan Gao Ye Cui Mengna Jiang Zhaoping Shen Jing Xiao Peng Xue Xiaoke Wang Shali Yu Qiyun Wu Xinyuan Zhao |
| author_sort | Fengxu Wang |
| collection | DOAJ |
| description | Nanoplastics are common environmental pollutants. As of now, research has yet to explore how exposure to nanomaterials during gestation might influence the risk of developing Alzheimer's disease (AD) in offspring. Throughout the research, we assessed the AD pathology in adult offspring of mice prenatal 80 nm polystyrene nanoparticles (PS-NPs) exposure. In contrast with the control group, prenatal PS-NPs exposure obviously decreased brain tissue weight and the organ coefficient (brain weight/body weight) in adult male mice, but it only led to changes in the low-dose group of female mice. Histological examination of the adult offspring brains revealed alterations following exposure to PS-NPs during gestation. Specifically, there was a substantial reduction in neuron cells, significant changes in the number of Nissl bodies, noticeable loss of cell nucleus, and increased presence of neurofibrillary tangles in adult offspring mice exposed to PS-NPs during gestation. Furthermore, the phosphorylation levels of tau proteins at ser396 and ser199 were dramatically enhanced in the PS-NPs exposed group. Furthermore, the expression of Aβ protein was markedly increased, consistent with typical AD pathological features. Our findings suggest that being exposed to PS-NPs during pregnancy substantially raises the risk of AD in offspring. |
| format | Article |
| id | doaj-art-4ea4d92610de4dfaad41ae9e8319d032 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-4ea4d92610de4dfaad41ae9e8319d0322025-02-12T05:30:08ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117736Exposure to nano-polystyrene during pregnancy leads to Alzheimer's disease-related pathological changes in adult offspringFengxu Wang0Jin Wang1Na Luo2Yonghua Luo3Zhengnan Gao4Ye Cui5Mengna Jiang6Zhaoping Shen7Jing Xiao8Peng Xue9Xiaoke Wang10Shali Yu11Qiyun Wu12Xinyuan Zhao13Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, ChinaDepartment of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, ChinaDepartment of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, ChinaNantong Fourth People's Hospital, Nantong, ChinaDepartment of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, ChinaDepartment of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, ChinaDepartment of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, ChinaDepartment of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, ChinaDepartment of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, ChinaDepartment of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, ChinaDepartment of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, ChinaDepartment of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China; Corresponding authors.Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China; Corresponding authors.Department of Occupational Medicine and Environmental Toxicology, Nantong Key Laboratory of Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China; Corresponding authors.Nanoplastics are common environmental pollutants. As of now, research has yet to explore how exposure to nanomaterials during gestation might influence the risk of developing Alzheimer's disease (AD) in offspring. Throughout the research, we assessed the AD pathology in adult offspring of mice prenatal 80 nm polystyrene nanoparticles (PS-NPs) exposure. In contrast with the control group, prenatal PS-NPs exposure obviously decreased brain tissue weight and the organ coefficient (brain weight/body weight) in adult male mice, but it only led to changes in the low-dose group of female mice. Histological examination of the adult offspring brains revealed alterations following exposure to PS-NPs during gestation. Specifically, there was a substantial reduction in neuron cells, significant changes in the number of Nissl bodies, noticeable loss of cell nucleus, and increased presence of neurofibrillary tangles in adult offspring mice exposed to PS-NPs during gestation. Furthermore, the phosphorylation levels of tau proteins at ser396 and ser199 were dramatically enhanced in the PS-NPs exposed group. Furthermore, the expression of Aβ protein was markedly increased, consistent with typical AD pathological features. Our findings suggest that being exposed to PS-NPs during pregnancy substantially raises the risk of AD in offspring.http://www.sciencedirect.com/science/article/pii/S0147651325000727PS-NPsNanotoxicityPrenatal exposureBrain damageAlzheimer's disease |
| spellingShingle | Fengxu Wang Jin Wang Na Luo Yonghua Luo Zhengnan Gao Ye Cui Mengna Jiang Zhaoping Shen Jing Xiao Peng Xue Xiaoke Wang Shali Yu Qiyun Wu Xinyuan Zhao Exposure to nano-polystyrene during pregnancy leads to Alzheimer's disease-related pathological changes in adult offspring Ecotoxicology and Environmental Safety PS-NPs Nanotoxicity Prenatal exposure Brain damage Alzheimer's disease |
| title | Exposure to nano-polystyrene during pregnancy leads to Alzheimer's disease-related pathological changes in adult offspring |
| title_full | Exposure to nano-polystyrene during pregnancy leads to Alzheimer's disease-related pathological changes in adult offspring |
| title_fullStr | Exposure to nano-polystyrene during pregnancy leads to Alzheimer's disease-related pathological changes in adult offspring |
| title_full_unstemmed | Exposure to nano-polystyrene during pregnancy leads to Alzheimer's disease-related pathological changes in adult offspring |
| title_short | Exposure to nano-polystyrene during pregnancy leads to Alzheimer's disease-related pathological changes in adult offspring |
| title_sort | exposure to nano polystyrene during pregnancy leads to alzheimer s disease related pathological changes in adult offspring |
| topic | PS-NPs Nanotoxicity Prenatal exposure Brain damage Alzheimer's disease |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000727 |
| work_keys_str_mv | AT fengxuwang exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT jinwang exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT naluo exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT yonghualuo exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT zhengnangao exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT yecui exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT mengnajiang exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT zhaopingshen exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT jingxiao exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT pengxue exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT xiaokewang exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT shaliyu exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT qiyunwu exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring AT xinyuanzhao exposuretonanopolystyreneduringpregnancyleadstoalzheimersdiseaserelatedpathologicalchangesinadultoffspring |