Diagnosis of carbon monoxide exposure in clinical research and practice: A scoping review.
<h4>Objective</h4>To undertake a scoping review to identify methods and diagnostic levels used in determining unintentional, non-fire related carbon monoxide exposure.<h4>Design</h4>Online databases and grey literature were searched from 1946 to 2023 identifying 80 papers whe...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0300989 |
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| author | Phil Moss Natasha Matthews Rosalie McDonald Heather Jarman |
| author_facet | Phil Moss Natasha Matthews Rosalie McDonald Heather Jarman |
| author_sort | Phil Moss |
| collection | DOAJ |
| description | <h4>Objective</h4>To undertake a scoping review to identify methods and diagnostic levels used in determining unintentional, non-fire related carbon monoxide exposure.<h4>Design</h4>Online databases and grey literature were searched from 1946 to 2023 identifying 80 papers where carbon monoxide levels were reported.<h4>Results</h4>80 papers were included; 71 research studies and 9 clinical guidelines. Four methods were described: blood carboxyhaemoglobin (arterial or venous blood analysis), carbon monoxide oximetry (SpO2), expired carbon monoxide, and ambient carbon monoxide sampling. Blood analysis methods predominated (60.0% of the papers). Multiple methods of measurement were used in 26 (32.5%) of the papers. Diagnostic levels for carboxyhaemoglobin were described in 54 (67.5%) papers, ranging between 2% and 15%. 26 (32.5%) papers reported diagnostic levels that were adjusted for the smoking status of the patient.<h4>Conclusions</h4>Four methods were found for use in different settings. Variability in diagnostic thresholds impairs diagnostic accuracy. Agreement on standardised diagnostic levels is required to enable consistent diagnosis of unintentional, non-fire related carbon monoxide exposure. |
| format | Article |
| id | doaj-art-4f8a7f1e47da425786388bac1a264953 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-4f8a7f1e47da425786388bac1a2649532025-02-10T05:30:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e030098910.1371/journal.pone.0300989Diagnosis of carbon monoxide exposure in clinical research and practice: A scoping review.Phil MossNatasha MatthewsRosalie McDonaldHeather Jarman<h4>Objective</h4>To undertake a scoping review to identify methods and diagnostic levels used in determining unintentional, non-fire related carbon monoxide exposure.<h4>Design</h4>Online databases and grey literature were searched from 1946 to 2023 identifying 80 papers where carbon monoxide levels were reported.<h4>Results</h4>80 papers were included; 71 research studies and 9 clinical guidelines. Four methods were described: blood carboxyhaemoglobin (arterial or venous blood analysis), carbon monoxide oximetry (SpO2), expired carbon monoxide, and ambient carbon monoxide sampling. Blood analysis methods predominated (60.0% of the papers). Multiple methods of measurement were used in 26 (32.5%) of the papers. Diagnostic levels for carboxyhaemoglobin were described in 54 (67.5%) papers, ranging between 2% and 15%. 26 (32.5%) papers reported diagnostic levels that were adjusted for the smoking status of the patient.<h4>Conclusions</h4>Four methods were found for use in different settings. Variability in diagnostic thresholds impairs diagnostic accuracy. Agreement on standardised diagnostic levels is required to enable consistent diagnosis of unintentional, non-fire related carbon monoxide exposure.https://doi.org/10.1371/journal.pone.0300989 |
| spellingShingle | Phil Moss Natasha Matthews Rosalie McDonald Heather Jarman Diagnosis of carbon monoxide exposure in clinical research and practice: A scoping review. PLoS ONE |
| title | Diagnosis of carbon monoxide exposure in clinical research and practice: A scoping review. |
| title_full | Diagnosis of carbon monoxide exposure in clinical research and practice: A scoping review. |
| title_fullStr | Diagnosis of carbon monoxide exposure in clinical research and practice: A scoping review. |
| title_full_unstemmed | Diagnosis of carbon monoxide exposure in clinical research and practice: A scoping review. |
| title_short | Diagnosis of carbon monoxide exposure in clinical research and practice: A scoping review. |
| title_sort | diagnosis of carbon monoxide exposure in clinical research and practice a scoping review |
| url | https://doi.org/10.1371/journal.pone.0300989 |
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