Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysis
Vascular cognitive impairment (VCI) is increasingly recognized as the second most prevalent cause of dementia, primarily attributed to vascular risk factors and cerebrovascular disease. Numerous studies suggest that blood biomarkers may play a crucial role in the detection and prognosis of VCI. This...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1496711/full |
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| author | Weiquan Huang Libin Liao Qian Liu Rongchao Ma Xuan He Xuan He Xiaoqiong Du Dujuan Sha Dujuan Sha Dujuan Sha Dujuan Sha |
| author_facet | Weiquan Huang Libin Liao Qian Liu Rongchao Ma Xuan He Xuan He Xiaoqiong Du Dujuan Sha Dujuan Sha Dujuan Sha Dujuan Sha |
| author_sort | Weiquan Huang |
| collection | DOAJ |
| description | Vascular cognitive impairment (VCI) is increasingly recognized as the second most prevalent cause of dementia, primarily attributed to vascular risk factors and cerebrovascular disease. Numerous studies suggest that blood biomarkers may play a crucial role in the detection and prognosis of VCI. This study conducted a meta-analysis to evaluate the potential of various blood biomarkers associated with neuronal function as indicators of VCI. We searched four major databases—PubMed, Embase, Web of Science, and the Cochrane Library—up to December 31, 2023, for research on blood biomarkers for VCI. Of the 4,043 studies identified, 30 met the inclusion criteria for this review. The nine peripheral biomarkers analyzed for their association with neuronal function include amyloid beta 42 (Aβ42), amyloid beta 40 (Aβ40), Aβ42/Aβ40 ratio, total Tau (t-Tau), phosphorylated tau 181 (p-tau 181), neurofilament light (NfL), brain-derived neurotrophic factor (BDNF), S100B, and soluble receptor for advanced glycation end products (sRAGE). Our findings reveal that peripheral Aβ42, Aβ42/Aβ40 ratio, NfL, and S100B significantly differ between VCI and non-VCI groups, indicating their potential as blood biomarkers for VCI. |
| format | Article |
| id | doaj-art-4fc68d7f48ba45d483eb5735c654570c |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-4fc68d7f48ba45d483eb5735c654570c2025-02-07T05:10:35ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-02-011610.3389/fneur.2025.14967111496711Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysisWeiquan Huang0Libin Liao1Qian Liu2Rongchao Ma3Xuan He4Xuan He5Xiaoqiong Du6Dujuan Sha7Dujuan Sha8Dujuan Sha9Dujuan Sha10Department of General Practice, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of General Practice, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of General Practice, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University, Nanjing, Jiangsu, ChinaDepartment of General Practice, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of General Practice, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing, ChinaDepartment of General Practice, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaDepartment of General Practice, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of General Practice, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University, Nanjing, Jiangsu, ChinaDepartment of General Practice, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, ChinaState Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing, ChinaVascular cognitive impairment (VCI) is increasingly recognized as the second most prevalent cause of dementia, primarily attributed to vascular risk factors and cerebrovascular disease. Numerous studies suggest that blood biomarkers may play a crucial role in the detection and prognosis of VCI. This study conducted a meta-analysis to evaluate the potential of various blood biomarkers associated with neuronal function as indicators of VCI. We searched four major databases—PubMed, Embase, Web of Science, and the Cochrane Library—up to December 31, 2023, for research on blood biomarkers for VCI. Of the 4,043 studies identified, 30 met the inclusion criteria for this review. The nine peripheral biomarkers analyzed for their association with neuronal function include amyloid beta 42 (Aβ42), amyloid beta 40 (Aβ40), Aβ42/Aβ40 ratio, total Tau (t-Tau), phosphorylated tau 181 (p-tau 181), neurofilament light (NfL), brain-derived neurotrophic factor (BDNF), S100B, and soluble receptor for advanced glycation end products (sRAGE). Our findings reveal that peripheral Aβ42, Aβ42/Aβ40 ratio, NfL, and S100B significantly differ between VCI and non-VCI groups, indicating their potential as blood biomarkers for VCI.https://www.frontiersin.org/articles/10.3389/fneur.2025.1496711/fullvascular cognitive impairmentbiomarkersbloodneuronal functionsystematic review |
| spellingShingle | Weiquan Huang Libin Liao Qian Liu Rongchao Ma Xuan He Xuan He Xiaoqiong Du Dujuan Sha Dujuan Sha Dujuan Sha Dujuan Sha Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysis Frontiers in Neurology vascular cognitive impairment biomarkers blood neuronal function systematic review |
| title | Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysis |
| title_full | Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysis |
| title_fullStr | Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysis |
| title_full_unstemmed | Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysis |
| title_short | Blood biomarkers for vascular cognitive impairment based on neuronal function: a systematic review and meta-analysis |
| title_sort | blood biomarkers for vascular cognitive impairment based on neuronal function a systematic review and meta analysis |
| topic | vascular cognitive impairment biomarkers blood neuronal function systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1496711/full |
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