Second Trimester Genetic Amniocentesis: Five- Year Experience of a Maternal- Fetal Medicine Unit
OBJECTİVE: The objective of this study is to identify the annual variations amniocentesis indications such as change in maternal age, cytogenetic results, and other indications. Another outcome is the investigation of the relationship between indications for amniocentesis and the distribution of ch...
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Medical Network
2013-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/207 |
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| author | Orkun Çetin Fatma Ferda Verit Atmaca Ali Galip Zebitay Ayşegül Deregözü Begüm Aydoğan Seda Keskin Oğuz Yücel |
| author_facet | Orkun Çetin Fatma Ferda Verit Atmaca Ali Galip Zebitay Ayşegül Deregözü Begüm Aydoğan Seda Keskin Oğuz Yücel |
| author_sort | Orkun Çetin |
| collection | DOAJ |
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OBJECTİVE: The objective of this study is to identify the annual variations amniocentesis indications such as change in maternal age, cytogenetic results, and other indications. Another outcome is the investigation of the relationship between indications for amniocentesis and the distribution of chromosomal abnormalities.
STUDY DESIGN: This study was designed as a retrospective analysis of amniocentesis results of the 1667 pregnant patients between January 2007 and December 2012 in the Süleymaniye Women’s Health Education and Research Hospital. The karyotype results, indications for intervention and complications during procedure were reported.
RESULTS: Total chromosome abnormalities were detected in 101 cases out of 1667 patients which correspond to a 6.1% of the total results. Distribution of the chromosomal abnormality detection rate with respect to the amniocentesis indication was 4.2%; in the abnormal first trimester screening tests group; 5.3% in the abnormal second trimester maternal serum screening group, 18.7% in the fetal malformations in previous pregnancy group, and 7.1%. in the abnormal ultrasound findings group.
CONCLUSION: Amniocentesis is the most common invasive procedure for prenatal diagnosis. Although the advanced maternal age is still an important indication, there has been significant development of both new markers and technology making this indication for amniocentesis questionable. Prenatal ultrasonography for the soft markers of chromosomal aneuploidy in association with the maternal serum biochemical screening tests should be evaluated during the decision process for amniocentesis.
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| format | Article |
| id | doaj-art-500b76fa7d4d4eb6bbde625b2cca25eb |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-500b76fa7d4d4eb6bbde625b2cca25eb2025-02-11T21:22:20ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182013-12-01193145Second Trimester Genetic Amniocentesis: Five- Year Experience of a Maternal- Fetal Medicine UnitOrkun Çetin0Fatma Ferda Verit Atmaca1Ali Galip Zebitay2Ayşegül Deregözü3Begüm Aydoğan4Seda Keskin5Oğuz Yücel6Süleymaniye Women’s Health Education and Research Hospital, İstanbulSüleymaniye Women’s Health Education and Research Hospital, İstanbulSüleymaniye Women’s Health Education and Research Hospital, İstanbulSüleymaniye Women’s Health Education and Research Hospital, İstanbulŞişli Etfal Education and Research Hospital, İstanbulSüleymaniye Women’s Health Education and Research Hospital, İstanbulSüleymaniye Women’s Health Education and Research Hospital, İstanbul OBJECTİVE: The objective of this study is to identify the annual variations amniocentesis indications such as change in maternal age, cytogenetic results, and other indications. Another outcome is the investigation of the relationship between indications for amniocentesis and the distribution of chromosomal abnormalities. STUDY DESIGN: This study was designed as a retrospective analysis of amniocentesis results of the 1667 pregnant patients between January 2007 and December 2012 in the Süleymaniye Women’s Health Education and Research Hospital. The karyotype results, indications for intervention and complications during procedure were reported. RESULTS: Total chromosome abnormalities were detected in 101 cases out of 1667 patients which correspond to a 6.1% of the total results. Distribution of the chromosomal abnormality detection rate with respect to the amniocentesis indication was 4.2%; in the abnormal first trimester screening tests group; 5.3% in the abnormal second trimester maternal serum screening group, 18.7% in the fetal malformations in previous pregnancy group, and 7.1%. in the abnormal ultrasound findings group. CONCLUSION: Amniocentesis is the most common invasive procedure for prenatal diagnosis. Although the advanced maternal age is still an important indication, there has been significant development of both new markers and technology making this indication for amniocentesis questionable. Prenatal ultrasonography for the soft markers of chromosomal aneuploidy in association with the maternal serum biochemical screening tests should be evaluated during the decision process for amniocentesis. https://gorm.com.tr/index.php/GORM/article/view/207Genetic amniocentesisChromosomal abnormalitiesDetection rate |
| spellingShingle | Orkun Çetin Fatma Ferda Verit Atmaca Ali Galip Zebitay Ayşegül Deregözü Begüm Aydoğan Seda Keskin Oğuz Yücel Second Trimester Genetic Amniocentesis: Five- Year Experience of a Maternal- Fetal Medicine Unit Gynecology Obstetrics & Reproductive Medicine Genetic amniocentesis Chromosomal abnormalities Detection rate |
| title | Second Trimester Genetic Amniocentesis: Five- Year Experience of a Maternal- Fetal Medicine Unit |
| title_full | Second Trimester Genetic Amniocentesis: Five- Year Experience of a Maternal- Fetal Medicine Unit |
| title_fullStr | Second Trimester Genetic Amniocentesis: Five- Year Experience of a Maternal- Fetal Medicine Unit |
| title_full_unstemmed | Second Trimester Genetic Amniocentesis: Five- Year Experience of a Maternal- Fetal Medicine Unit |
| title_short | Second Trimester Genetic Amniocentesis: Five- Year Experience of a Maternal- Fetal Medicine Unit |
| title_sort | second trimester genetic amniocentesis five year experience of a maternal fetal medicine unit |
| topic | Genetic amniocentesis Chromosomal abnormalities Detection rate |
| url | https://gorm.com.tr/index.php/GORM/article/view/207 |
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