Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021
Abstract Urinary tract infections (UTIs) are prevalent; however, comprehensive and current epidemiological data remain scarce. This study examined the global, national, and regional burden of UTIs by sex, age, and socio-demographic index (SDI) from 1990 to 2021. The 2021 Global Burden of Disease stu...
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2025-02-01
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| author | Yining He Jing Zhao Lanhui Wang Chao Han Ruxue Yan Peiqi Zhu Tianyang Qian Siyao Yu Xiaolin Zhu Weiming He |
| author_facet | Yining He Jing Zhao Lanhui Wang Chao Han Ruxue Yan Peiqi Zhu Tianyang Qian Siyao Yu Xiaolin Zhu Weiming He |
| author_sort | Yining He |
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| description | Abstract Urinary tract infections (UTIs) are prevalent; however, comprehensive and current epidemiological data remain scarce. This study examined the global, national, and regional burden of UTIs by sex, age, and socio-demographic index (SDI) from 1990 to 2021. The 2021 Global Burden of Disease study included age-standardised incidence rate (ASIR), age-standardised prevalence rate (ASPR), age-standardised death rate (ASDR), and age-standardised disability-adjusted life years rate (ASDAR). The estimated annual percentage change was used to depict temporal trends, whereas Pearson correlation analysis explore its correlation with the human development index (HDI), the SDI, and age-standardised rates (ASRs). An autoregressive integrated moving average model forecasted the UTI burden trends. From 1990 to 2021, the number of UTI cases increased by 66.45%, reaching 4.49 billion cases, with an ASIR of 5,531.88 per 100,000 population. The greatest incidence of UTIs was seen in women and older adult men. Tropical Latin America and low–middle SDI regions exhibited the highest ASIR, ASPR, ASDR, and ASDAR, while East Asia showed the lowest. ASDR and ASDAR decreased with higher SDI levels. ASR and HDI were weakly positively correlated with ASDR and ASDAR. ASIR, ASPR, and ASDAR are projected to increase until 2050. The global burden of UTIs is rising and is influenced by geographical location, age, sex, and economic development, crucial for guiding medical practices and forming relevant policies. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-50272f73fba945828a5bfea2ddb8195e2025-02-09T12:29:08ZengNature PortfolioScientific Reports2045-23222025-02-0115111210.1038/s41598-025-89240-5Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021Yining He0Jing Zhao1Lanhui Wang2Chao Han3Ruxue Yan4Peiqi Zhu5Tianyang Qian6Siyao Yu7Xiaolin Zhu8Weiming He9Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineDivision of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineDivision of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineDivision of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineDivision of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineDivision of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineDivision of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineDivision of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineDepartment of Nephrology, the Second Affiliated Hospital of Nanjing University of Chinese MedicineDivision of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese MedicineAbstract Urinary tract infections (UTIs) are prevalent; however, comprehensive and current epidemiological data remain scarce. This study examined the global, national, and regional burden of UTIs by sex, age, and socio-demographic index (SDI) from 1990 to 2021. The 2021 Global Burden of Disease study included age-standardised incidence rate (ASIR), age-standardised prevalence rate (ASPR), age-standardised death rate (ASDR), and age-standardised disability-adjusted life years rate (ASDAR). The estimated annual percentage change was used to depict temporal trends, whereas Pearson correlation analysis explore its correlation with the human development index (HDI), the SDI, and age-standardised rates (ASRs). An autoregressive integrated moving average model forecasted the UTI burden trends. From 1990 to 2021, the number of UTI cases increased by 66.45%, reaching 4.49 billion cases, with an ASIR of 5,531.88 per 100,000 population. The greatest incidence of UTIs was seen in women and older adult men. Tropical Latin America and low–middle SDI regions exhibited the highest ASIR, ASPR, ASDR, and ASDAR, while East Asia showed the lowest. ASDR and ASDAR decreased with higher SDI levels. ASR and HDI were weakly positively correlated with ASDR and ASDAR. ASIR, ASPR, and ASDAR are projected to increase until 2050. The global burden of UTIs is rising and is influenced by geographical location, age, sex, and economic development, crucial for guiding medical practices and forming relevant policies.https://doi.org/10.1038/s41598-025-89240-5Global burden of disease studyUrinary tract infectionIncidencePrevalenceMortalityDisability-adjusted life years |
| spellingShingle | Yining He Jing Zhao Lanhui Wang Chao Han Ruxue Yan Peiqi Zhu Tianyang Qian Siyao Yu Xiaolin Zhu Weiming He Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021 Scientific Reports Global burden of disease study Urinary tract infection Incidence Prevalence Mortality Disability-adjusted life years |
| title | Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021 |
| title_full | Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021 |
| title_fullStr | Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021 |
| title_full_unstemmed | Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021 |
| title_short | Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021 |
| title_sort | epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021 |
| topic | Global burden of disease study Urinary tract infection Incidence Prevalence Mortality Disability-adjusted life years |
| url | https://doi.org/10.1038/s41598-025-89240-5 |
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