Dysplasia of stomach epithelium at chronic <i>H. pylori</i>-associated gastritis: is everything quite so simple?
The aim of publication. Analysis of clinical cases demonstrating differentiated management approach at chronic H. pylori-associated gastritis with stomach epithelium dysplasia.Key points. Detection of high grade (severe) dysplasia is associated to high risk of early, invasive stomach cancer or its r...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2015-07-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1021 |
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| author | T. L. Lapina A. S. Tertychny S. S. Pirogov V. V. Sokolov I. M. Kartavenko E. R. Nasretdinova A. A. Paraskevova O. A. Storonova O. S. Lyashenko Ye. Yu. Yur'yeva A. S. Trukhmanov V. T. Ivashkin |
| author_facet | T. L. Lapina A. S. Tertychny S. S. Pirogov V. V. Sokolov I. M. Kartavenko E. R. Nasretdinova A. A. Paraskevova O. A. Storonova O. S. Lyashenko Ye. Yu. Yur'yeva A. S. Trukhmanov V. T. Ivashkin |
| author_sort | T. L. Lapina |
| collection | DOAJ |
| description | The aim of publication. Analysis of clinical cases demonstrating differentiated management approach at chronic H. pylori-associated gastritis with stomach epithelium dysplasia.Key points. Detection of high grade (severe) dysplasia is associated to high risk of early, invasive stomach cancer or its rapid development. In presented clinical case adenocarcinoma has been found in 60 year-old male patient with deep submucosa invasion simultaneously with high grade dysplasia. According to comprehensive endoscopic investigation endoscopic treatment option was considered impossible and patient underwent distal subtotal stomach resection with Roux-en-Y anastomosis and D2 regional lymph node dissection. At low grade (mild) dysplasia complex endoscopic investigation is recommended to identify local premalignant lesions of the stomach mucosa, and at ruling them out — to determine adequate therapy. So, in presented clinical case H. pylori eradication therapy in 45-year old patient has led to disappearance of changes suspicious to epithelial dysplasia. The term «indefinite for dysplasia» is applied to atypical changes which can be characterized as of premalignant or reactive nature. It is provisional conclusion which requires specifying endoscopy with guided biopsy and repeated histological conclusion.Conclusion. Prognosis and management approach in the cases with histological conclusion of stomach epithelium dysplasia should be determined according to comprehensive multimodal endoscopic investigation with guided biopsy. |
| format | Article |
| id | doaj-art-5144a740224948ca87f1fc1de63ecefd |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2015-07-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-5144a740224948ca87f1fc1de63ecefd2025-02-10T16:14:34ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732015-07-0125390101628Dysplasia of stomach epithelium at chronic <i>H. pylori</i>-associated gastritis: is everything quite so simple?T. L. Lapina0A. S. Tertychny1S. S. Pirogov2V. V. Sokolov3I. M. Kartavenko4E. R. Nasretdinova5A. A. Paraskevova6O. A. Storonova7O. S. Lyashenko8Ye. Yu. Yur'yeva9A. S. Trukhmanov10V. T. Ivashkin11State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationGertsen Moscow oncological research institute, branch Federal government-financed institution «National Medical Research Radiological Centre», Ministry of healthcare of the Russian FederationGertsen Moscow oncological research institute, branch Federal government-financed institution «National Medical Research Radiological Centre», Ministry of healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationThe aim of publication. Analysis of clinical cases demonstrating differentiated management approach at chronic H. pylori-associated gastritis with stomach epithelium dysplasia.Key points. Detection of high grade (severe) dysplasia is associated to high risk of early, invasive stomach cancer or its rapid development. In presented clinical case adenocarcinoma has been found in 60 year-old male patient with deep submucosa invasion simultaneously with high grade dysplasia. According to comprehensive endoscopic investigation endoscopic treatment option was considered impossible and patient underwent distal subtotal stomach resection with Roux-en-Y anastomosis and D2 regional lymph node dissection. At low grade (mild) dysplasia complex endoscopic investigation is recommended to identify local premalignant lesions of the stomach mucosa, and at ruling them out — to determine adequate therapy. So, in presented clinical case H. pylori eradication therapy in 45-year old patient has led to disappearance of changes suspicious to epithelial dysplasia. The term «indefinite for dysplasia» is applied to atypical changes which can be characterized as of premalignant or reactive nature. It is provisional conclusion which requires specifying endoscopy with guided biopsy and repeated histological conclusion.Conclusion. Prognosis and management approach in the cases with histological conclusion of stomach epithelium dysplasia should be determined according to comprehensive multimodal endoscopic investigation with guided biopsy.https://www.gastro-j.ru/jour/article/view/1021dysplasiaconfocal endomicroscopyatrophic gastritish. pylori |
| spellingShingle | T. L. Lapina A. S. Tertychny S. S. Pirogov V. V. Sokolov I. M. Kartavenko E. R. Nasretdinova A. A. Paraskevova O. A. Storonova O. S. Lyashenko Ye. Yu. Yur'yeva A. S. Trukhmanov V. T. Ivashkin Dysplasia of stomach epithelium at chronic <i>H. pylori</i>-associated gastritis: is everything quite so simple? Российский журнал гастроэнтерологии, гепатологии, колопроктологии dysplasia confocal endomicroscopy atrophic gastritis h. pylori |
| title | Dysplasia of stomach epithelium at chronic <i>H. pylori</i>-associated gastritis: is everything quite so simple? |
| title_full | Dysplasia of stomach epithelium at chronic <i>H. pylori</i>-associated gastritis: is everything quite so simple? |
| title_fullStr | Dysplasia of stomach epithelium at chronic <i>H. pylori</i>-associated gastritis: is everything quite so simple? |
| title_full_unstemmed | Dysplasia of stomach epithelium at chronic <i>H. pylori</i>-associated gastritis: is everything quite so simple? |
| title_short | Dysplasia of stomach epithelium at chronic <i>H. pylori</i>-associated gastritis: is everything quite so simple? |
| title_sort | dysplasia of stomach epithelium at chronic i h pylori i associated gastritis is everything quite so simple |
| topic | dysplasia confocal endomicroscopy atrophic gastritis h. pylori |
| url | https://www.gastro-j.ru/jour/article/view/1021 |
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