Autophagy-lysosome pathway in insulin & glucagon homeostasis
Lysosome, a highly dynamic organelle, is an important nutrient sensing center. They utilize different ion channels and transporters to complete the mission in degradation, trafficking, nutrient sensing and integration of various metabolic pathways to maintain cellular homeostasis. Glucose homeostasi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1541794/full |
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| author | Yi Wu Yi Wu Yi Wu Hui Wang Huoyan Xu |
| author_facet | Yi Wu Yi Wu Yi Wu Hui Wang Huoyan Xu |
| author_sort | Yi Wu |
| collection | DOAJ |
| description | Lysosome, a highly dynamic organelle, is an important nutrient sensing center. They utilize different ion channels and transporters to complete the mission in degradation, trafficking, nutrient sensing and integration of various metabolic pathways to maintain cellular homeostasis. Glucose homeostasis relies on tightly regulated insulin secretion by pancreatic β cells, and their dysfunction is a hallmark of type 2 diabetes. Glucagon also plays an important role in hyperglycemia in diabetic patients. Currently, lysosome has been recognized as a nutrient hub to regulate the homeostasis of insulin and other hormones. In this review, we will discuss recent advances in understanding lysosome-mediated autophagy and lysosomal proteins involved in maintaining insulin and glucagon homeostasis, as well as their contributions to the etiology of diabetes. |
| format | Article |
| id | doaj-art-52790be1c0c84b0da41aaf58ffcedd39 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-52790be1c0c84b0da41aaf58ffcedd392025-02-10T06:49:53ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15417941541794Autophagy-lysosome pathway in insulin & glucagon homeostasisYi Wu0Yi Wu1Yi Wu2Hui Wang3Huoyan Xu4School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, ChinaShanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, ChinaShanghai Key Laboratory of Molecular Imaging, School of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai, ChinaLysosome, a highly dynamic organelle, is an important nutrient sensing center. They utilize different ion channels and transporters to complete the mission in degradation, trafficking, nutrient sensing and integration of various metabolic pathways to maintain cellular homeostasis. Glucose homeostasis relies on tightly regulated insulin secretion by pancreatic β cells, and their dysfunction is a hallmark of type 2 diabetes. Glucagon also plays an important role in hyperglycemia in diabetic patients. Currently, lysosome has been recognized as a nutrient hub to regulate the homeostasis of insulin and other hormones. In this review, we will discuss recent advances in understanding lysosome-mediated autophagy and lysosomal proteins involved in maintaining insulin and glucagon homeostasis, as well as their contributions to the etiology of diabetes.https://www.frontiersin.org/articles/10.3389/fendo.2025.1541794/fulllysosomeautophagyinsulin homeostasisglucagon homeostasisdiabetes |
| spellingShingle | Yi Wu Yi Wu Yi Wu Hui Wang Huoyan Xu Autophagy-lysosome pathway in insulin & glucagon homeostasis Frontiers in Endocrinology lysosome autophagy insulin homeostasis glucagon homeostasis diabetes |
| title | Autophagy-lysosome pathway in insulin & glucagon homeostasis |
| title_full | Autophagy-lysosome pathway in insulin & glucagon homeostasis |
| title_fullStr | Autophagy-lysosome pathway in insulin & glucagon homeostasis |
| title_full_unstemmed | Autophagy-lysosome pathway in insulin & glucagon homeostasis |
| title_short | Autophagy-lysosome pathway in insulin & glucagon homeostasis |
| title_sort | autophagy lysosome pathway in insulin glucagon homeostasis |
| topic | lysosome autophagy insulin homeostasis glucagon homeostasis diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1541794/full |
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