Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review)
Aim. To review the main mechanisms of functional disorders of the gastrointestinal tract and to present the materials of an Expert Council, which was held on 10 December 2021 in Moscow.Key points. The pathogenesis of the most common functional diseases of the gastrointestinal tract — functional dysp...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2022-05-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/655 |
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| author | V. T. Ivashkin I. V. Maev A. S. Trukhmanov A. A. Sheptulin T. L. Lapina V. I. Simanenkov K. A. Sokolov |
| author_facet | V. T. Ivashkin I. V. Maev A. S. Trukhmanov A. A. Sheptulin T. L. Lapina V. I. Simanenkov K. A. Sokolov |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | Aim. To review the main mechanisms of functional disorders of the gastrointestinal tract and to present the materials of an Expert Council, which was held on 10 December 2021 in Moscow.Key points. The pathogenesis of the most common functional diseases of the gastrointestinal tract — functional dyspepsia (FD) and irritable bowel syndrome (IBS) is multifactorial and includes motor disorders of various parts of the gastrointestinal tract, visceral hypersensitivity, changes in the intestinal microbiome, impairment of the permeability of the protective barrier, low-grade inflammation of the gastrointestinal mucosa, etc. This often leads to the prescription of a complex of various medications to such patients, which increases the risk of undesirable drug interactions and side effects. Multitargeted therapy involves the use of drugs that simultaneously affect different pathogenetic links. One of these drugs is Iberogast®, which normalizes gastrointestinal motility and visceral sensitivity, has an anti-inflammatory action and is highly effective in treatment of FD and IBS.Conclusion. In the treatment of functional gastrointestinal diseases characterized by multifactorial pathogenesis, preference should be given to multi-targeted therapy with the use of drugs that have an effect on its various links. |
| format | Article |
| id | doaj-art-544708026e62453ab092a5973b222042 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2022-05-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-544708026e62453ab092a5973b2220422025-02-10T16:14:37ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732022-05-0132171410.22416/1382-4376-2022-32-1-7-14459Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review)V. T. Ivashkin0I. V. Maev1A. S. Trukhmanov2A. A. Sheptulin3T. L. Lapina4V. I. Simanenkov5K. A. Sokolov6Sechenov First Moscow State University (Sechenov University)Yevdokimov Moscow State University of Medicine and DentistrySechenov First Moscow State University (Sechenov University)Sechenov First Moscow State University (Sechenov University)Sechenov First Moscow State University (Sechenov University)Mechnikov North-Western State Medical University“Bayer” JSCAim. To review the main mechanisms of functional disorders of the gastrointestinal tract and to present the materials of an Expert Council, which was held on 10 December 2021 in Moscow.Key points. The pathogenesis of the most common functional diseases of the gastrointestinal tract — functional dyspepsia (FD) and irritable bowel syndrome (IBS) is multifactorial and includes motor disorders of various parts of the gastrointestinal tract, visceral hypersensitivity, changes in the intestinal microbiome, impairment of the permeability of the protective barrier, low-grade inflammation of the gastrointestinal mucosa, etc. This often leads to the prescription of a complex of various medications to such patients, which increases the risk of undesirable drug interactions and side effects. Multitargeted therapy involves the use of drugs that simultaneously affect different pathogenetic links. One of these drugs is Iberogast®, which normalizes gastrointestinal motility and visceral sensitivity, has an anti-inflammatory action and is highly effective in treatment of FD and IBS.Conclusion. In the treatment of functional gastrointestinal diseases characterized by multifactorial pathogenesis, preference should be given to multi-targeted therapy with the use of drugs that have an effect on its various links.https://www.gastro-j.ru/jour/article/view/655gastrointestinal tractmotilityvisceral hypersensitivityinflammationiberogast® |
| spellingShingle | V. T. Ivashkin I. V. Maev A. S. Trukhmanov A. A. Sheptulin T. L. Lapina V. I. Simanenkov K. A. Sokolov Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review) Российский журнал гастроэнтерологии, гепатологии, колопроктологии gastrointestinal tract motility visceral hypersensitivity inflammation iberogast® |
| title | Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review) |
| title_full | Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review) |
| title_fullStr | Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review) |
| title_full_unstemmed | Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review) |
| title_short | Inflammation, impaired motor function and visceral hypersensitivity: the main mechanisms of functional disorders of the gastrointestinal tract (materials of the Expert Council and literature review) |
| title_sort | inflammation impaired motor function and visceral hypersensitivity the main mechanisms of functional disorders of the gastrointestinal tract materials of the expert council and literature review |
| topic | gastrointestinal tract motility visceral hypersensitivity inflammation iberogast® |
| url | https://www.gastro-j.ru/jour/article/view/655 |
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