Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms
Polymyxins, a class of cyclic peptide antibiotics, have become the last line of defense against gram-negative bacterial infections as the number of multidrug-resistant bacteria continues to rise. Heteroresistance refers to the presence of subpopulations within the same strain with varying sensitivit...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2024-11-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0159 |
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| _version_ | 1823865228894404608 |
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| author | LI Yanbing ZHOU Menglan XU Yingchun |
| author_facet | LI Yanbing ZHOU Menglan XU Yingchun |
| author_sort | LI Yanbing |
| collection | DOAJ |
| description | Polymyxins, a class of cyclic peptide antibiotics, have become the last line of defense against gram-negative bacterial infections as the number of multidrug-resistant bacteria continues to rise. Heteroresistance refers to the presence of subpopulations within the same strain with varying sensitivities to antibiotics, which cannot be detected by standard clinical tests and may result in treatment failure. In several common gram-negative bacteria, mutations in the PhoPQ and PmrAB two-component systems are key contributors to polymyxin heteroresistance. This review aims to summarize recent research on the mechanisms of polymyxin heteroresistance in gram-negative bacteria, so as to provide insights for developing rapid detection methods and improving clinical treatment strategies. |
| format | Article |
| id | doaj-art-5456b68bcbe54de39fcbb2a35439ae43 |
| institution | Kabale University |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-5456b68bcbe54de39fcbb2a35439ae432025-02-08T07:47:34ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812024-11-0116117718310.12290/xhyxzz.2024-0159Progress in the Study of Polymyxin Heteroresistance Molecular MechanismsLI YanbingZHOU MenglanXU YingchunPolymyxins, a class of cyclic peptide antibiotics, have become the last line of defense against gram-negative bacterial infections as the number of multidrug-resistant bacteria continues to rise. Heteroresistance refers to the presence of subpopulations within the same strain with varying sensitivities to antibiotics, which cannot be detected by standard clinical tests and may result in treatment failure. In several common gram-negative bacteria, mutations in the PhoPQ and PmrAB two-component systems are key contributors to polymyxin heteroresistance. This review aims to summarize recent research on the mechanisms of polymyxin heteroresistance in gram-negative bacteria, so as to provide insights for developing rapid detection methods and improving clinical treatment strategies.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0159polymyxinsheteroresistancegram-negative bacteriamolecular mechanism |
| spellingShingle | LI Yanbing ZHOU Menglan XU Yingchun Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms Xiehe Yixue Zazhi polymyxins heteroresistance gram-negative bacteria molecular mechanism |
| title | Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms |
| title_full | Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms |
| title_fullStr | Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms |
| title_full_unstemmed | Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms |
| title_short | Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms |
| title_sort | progress in the study of polymyxin heteroresistance molecular mechanisms |
| topic | polymyxins heteroresistance gram-negative bacteria molecular mechanism |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0159 |
| work_keys_str_mv | AT liyanbing progressinthestudyofpolymyxinheteroresistancemolecularmechanisms AT zhoumenglan progressinthestudyofpolymyxinheteroresistancemolecularmechanisms AT xuyingchun progressinthestudyofpolymyxinheteroresistancemolecularmechanisms |