18F-FDG PET/CT assessment of metabolic tumor burden predicts survival in patients with metastatic posterior uveal melanoma

18F-FDG PET/CT assessment of metabolic tumor burden predicts survival in patients with metastatic posterior uveal melanoma

Abstract The prognostic value of metabolic tumor burden parameters obtained from 18F-FDG PET/CT imaging was evaluated in this retrospective national multicenter study of patients with metastatic posterior uveal melanoma (PUM) and compared to the largest diameter of the largest metastatic lesion (LDL...

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Main Authors: Tine Gadegaard Hindso, Torben Martinussen, Camilla Wium Bjerrum, Sune Høgild Keller, Annika Loft, Mette Bagger Sjøl, Kristoffer Nissen, Carsten Faber, Marco Donia, Inge Marie Svane, Eva Ellebaek, Steffen Heegaard, Jens Folke Kiilgaard, Karine Madsen
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Uveal melanoma
FDG PET
Metabolic tumor burden
Metabolic tumor volume (MTV)
Total lesion glycolysis (TLG)
Survival
Online Access:https://doi.org/10.1038/s41598-025-88625-w
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Summary:Abstract The prognostic value of metabolic tumor burden parameters obtained from 18F-FDG PET/CT imaging was evaluated in this retrospective national multicenter study of patients with metastatic posterior uveal melanoma (PUM) and compared to the largest diameter of the largest metastatic lesion (LDLM) and the American Joint Committee on Cancer (AJCC) staging system. The Maximal Standard Uptake Value (SUVmax), Metabolic Tumor Volume (MTV), and Total Lesion Glycolysis (TLG) were obtained in 106 patients. Higher values of SUVmax (p = 0.007, log-rank), MTV (p < 0.001, log-rank), and TLG (p < 0.001, long-rank) were associated with shorter survival. The three parameters were also independent predictors in the multivariate Cox model, while the AJCC staging turned insignificant. Time-dependent positive predictive value (PPV) analysis and Receiver Operating Characteristics (ROC) curves showed that MTV (Area Under the Curve (AUC) = 0.78), TLG (AUC = 0.78), and LDLM (AUC = 0.76) were good predictors of 1-year survival. For the subset of 97 patients with liver metastases, the corresponding regional measurements in the liver tended to be even better predictors. In conclusion, MTV and TLG were found to be better predictors of survival in metastatic PUM than the AJCC staging system, but when LDLM was used as a continuous variable it showed an equally good prediction of 1-year survival.
ISSN:2045-2322

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