Neonatal Bacterial Meningitis: Single Reference Center Experience and Review of Current Literature: A Retrospective Cohort Study
OBJECTIVE: Despite improvements in neonatal care, neonatal bacterial meningitis is still an emerging problem worldwide with high rates of mortality. The present study evaluates data on suspected- and culture-proven neonatal bacterial meningitis in the light of a single tertiary reference center exp...
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Medical Network
2021-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1142 |
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| author | Alper Aykanat Hasan Tolga Celik Gulsen Hazirolan Sule Yigit Murat Yurdakok |
| author_facet | Alper Aykanat Hasan Tolga Celik Gulsen Hazirolan Sule Yigit Murat Yurdakok |
| author_sort | Alper Aykanat |
| collection | DOAJ |
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OBJECTIVE: Despite improvements in neonatal care, neonatal bacterial meningitis is still an emerging problem worldwide with high rates of mortality. The present study evaluates data on suspected- and culture-proven neonatal bacterial meningitis in the light of a single tertiary reference center experience in Turkey in comparison with the globe.
STUDY DESIGN: In this retrospective cohort study newborns admitted to Hacettepe University Ihsan Dogramaci Children’s Hospital Neonatal Intensive Care Unit during a 5-year-period between April 2014-May 2019 and who underwent atraumatic lumbar puncture were included.
RESULTS: Two hundred sixty-four patients fulfilled the inclusion criteria. Most common symptoms in all patients raised suspicion in favor of NBM and resulted in lumbar puncture were fever (34.5%, n=91), respiratory distress (31.1%, n=82), lethargy (31.1%, n=82), and apnea (26.1%, n=69). The incidence of culture-proven NBM among suspected patients was 5.7% (n=15/264); while the incidence is 3.1 per 1000 (15/4574) at all Neonatal Intensive Care Unit admissions. Respiratory distress (60.0%, n=9/15) and apnea (40.0%, n=6/15) were the most common symptoms in patients with NBM; which may be due to the predominance of premature newborns in the NBM group. The most common microorganisms in CSF cultures were coagulase-negative Staphylococci with Methicillin-resistant Staphylococcus epidermidis being most common among all.
CONCLUSIONS: The present study underlines high rates of culture-proven neonatal bacterial meningitis among suspected newborns despite improvements in modern health care, which raises attention to careful evaluation of these patients and early administration of properly-selected antibiotics. Our incidence rates are in keeping with studies from the developed world.
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| format | Article |
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| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Medical Network |
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| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-54b47bde48134e5ab41f7498484c6df02025-02-11T21:13:46ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182021-12-0127310.21613/GORM.2021.1142Neonatal Bacterial Meningitis: Single Reference Center Experience and Review of Current Literature: A Retrospective Cohort StudyAlper Aykanat0Hasan Tolga Celik1Gulsen Hazirolan2Sule Yigit3Murat Yurdakok4Hacettepe University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, 06100, Altındağ, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, 06100, Altındağ, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Medical Microbiology, 06100, Altındağ, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, 06100, Altındağ, Ankara, TurkeyHacettepe University Faculty of Medicine, Department of Pediatrics, Division of Neonatology, 06100, Altındağ, Ankara, Turkey OBJECTIVE: Despite improvements in neonatal care, neonatal bacterial meningitis is still an emerging problem worldwide with high rates of mortality. The present study evaluates data on suspected- and culture-proven neonatal bacterial meningitis in the light of a single tertiary reference center experience in Turkey in comparison with the globe. STUDY DESIGN: In this retrospective cohort study newborns admitted to Hacettepe University Ihsan Dogramaci Children’s Hospital Neonatal Intensive Care Unit during a 5-year-period between April 2014-May 2019 and who underwent atraumatic lumbar puncture were included. RESULTS: Two hundred sixty-four patients fulfilled the inclusion criteria. Most common symptoms in all patients raised suspicion in favor of NBM and resulted in lumbar puncture were fever (34.5%, n=91), respiratory distress (31.1%, n=82), lethargy (31.1%, n=82), and apnea (26.1%, n=69). The incidence of culture-proven NBM among suspected patients was 5.7% (n=15/264); while the incidence is 3.1 per 1000 (15/4574) at all Neonatal Intensive Care Unit admissions. Respiratory distress (60.0%, n=9/15) and apnea (40.0%, n=6/15) were the most common symptoms in patients with NBM; which may be due to the predominance of premature newborns in the NBM group. The most common microorganisms in CSF cultures were coagulase-negative Staphylococci with Methicillin-resistant Staphylococcus epidermidis being most common among all. CONCLUSIONS: The present study underlines high rates of culture-proven neonatal bacterial meningitis among suspected newborns despite improvements in modern health care, which raises attention to careful evaluation of these patients and early administration of properly-selected antibiotics. Our incidence rates are in keeping with studies from the developed world. https://gorm.com.tr/index.php/GORM/article/view/1142Bacterial meningitisEpidemiologyNeonatalPreterm newborn |
| spellingShingle | Alper Aykanat Hasan Tolga Celik Gulsen Hazirolan Sule Yigit Murat Yurdakok Neonatal Bacterial Meningitis: Single Reference Center Experience and Review of Current Literature: A Retrospective Cohort Study Gynecology Obstetrics & Reproductive Medicine Bacterial meningitis Epidemiology Neonatal Preterm newborn |
| title | Neonatal Bacterial Meningitis: Single Reference Center Experience and Review of Current Literature: A Retrospective Cohort Study |
| title_full | Neonatal Bacterial Meningitis: Single Reference Center Experience and Review of Current Literature: A Retrospective Cohort Study |
| title_fullStr | Neonatal Bacterial Meningitis: Single Reference Center Experience and Review of Current Literature: A Retrospective Cohort Study |
| title_full_unstemmed | Neonatal Bacterial Meningitis: Single Reference Center Experience and Review of Current Literature: A Retrospective Cohort Study |
| title_short | Neonatal Bacterial Meningitis: Single Reference Center Experience and Review of Current Literature: A Retrospective Cohort Study |
| title_sort | neonatal bacterial meningitis single reference center experience and review of current literature a retrospective cohort study |
| topic | Bacterial meningitis Epidemiology Neonatal Preterm newborn |
| url | https://gorm.com.tr/index.php/GORM/article/view/1142 |
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