Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis
BackgroundMedical therapy and interventional approaches have improved outcomes in patients with acute myocardial infarction (MI). However, these strategies are inadequate for replacing cells lost during tissue ischemia, thereby leaving behind noncontractile scar tissue. The a...
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JMIR Publications
2025-02-01
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| Series: | JMIR Research Protocols |
| Online Access: | https://www.researchprotocols.org/2025/1/e60591 |
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| author | Michael Vincent DiCaro Brianna Yee KaChon Lei Kavita Batra Buddhadeb Dawn |
| author_facet | Michael Vincent DiCaro Brianna Yee KaChon Lei Kavita Batra Buddhadeb Dawn |
| author_sort | Michael Vincent DiCaro |
| collection | DOAJ |
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BackgroundMedical therapy and interventional approaches have improved outcomes in patients with acute myocardial infarction (MI). However, these strategies are inadequate for replacing cells lost during tissue ischemia, thereby leaving behind noncontractile scar tissue. The anti-inflammatory and immune modulating properties of mesenchymal stem cells (MSCs) may prove useful in inducing functional cardiac regeneration following acute MI.
ObjectiveThis is a protocol for systematic review and meta-analysis that will aggregate and synthesize high-level clinical data on the effects of MSC therapy for acute MI. The findings of this study may serve as evidence for clinicians and researchers in guiding the use of MSC therapy as an adjunct to reperfusion and optimal medical therapy in patients with acute MI.
MethodsThe proposed systematic review is registered with PROSPERO (International Prospective Register of Systematic Reviews). A systematic search of bibliographical databases, including Embase, PubMed, and Cochrane was conducted from inception to June 2023 to identify English-language human studies with adult patients receiving MSC therapy and optimal medical therapy for acute MI in comparison with respective controls. Article screening was performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Data on functional cardiac outcomes and major adverse cardiac events were extracted and analyzed as primary outcomes.
ResultsLiterature search and article screening commenced in June 2023. Data extraction and analysis will be completed by October 2024. The findings will be synthesized and reported by the end of November 2024.
ConclusionsThis systematic review and meta-analysis will summarize the best available updated evidence from published randomized controlled trials on the effects of MSC therapy for the treatment of acute MI. The findings of this systematic review and meta-analysis may shed light on the efficacy of MSC therapy in improving cardiac functional and structural parameters and reducing adverse cardiac events following acute MI.
Trial RegistrationPROSPERO CRD42024522398; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=522398
International Registered Report Identifier (IRRID)DERR1-10.2196/60591 |
| format | Article |
| id | doaj-art-55943f1b44864bf48ae595a325ed6f34 |
| institution | Kabale University |
| issn | 1929-0748 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | JMIR Publications |
| record_format | Article |
| series | JMIR Research Protocols |
| spelling | doaj-art-55943f1b44864bf48ae595a325ed6f342025-02-06T18:01:12ZengJMIR PublicationsJMIR Research Protocols1929-07482025-02-0114e6059110.2196/60591Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-AnalysisMichael Vincent DiCarohttps://orcid.org/0000-0003-3376-4608Brianna Yeehttps://orcid.org/0009-0009-1948-5099KaChon Leihttps://orcid.org/0000-0002-3696-195XKavita Batrahttps://orcid.org/0000-0002-0722-0191Buddhadeb Dawnhttps://orcid.org/0000-0001-5890-115X BackgroundMedical therapy and interventional approaches have improved outcomes in patients with acute myocardial infarction (MI). However, these strategies are inadequate for replacing cells lost during tissue ischemia, thereby leaving behind noncontractile scar tissue. The anti-inflammatory and immune modulating properties of mesenchymal stem cells (MSCs) may prove useful in inducing functional cardiac regeneration following acute MI. ObjectiveThis is a protocol for systematic review and meta-analysis that will aggregate and synthesize high-level clinical data on the effects of MSC therapy for acute MI. The findings of this study may serve as evidence for clinicians and researchers in guiding the use of MSC therapy as an adjunct to reperfusion and optimal medical therapy in patients with acute MI. MethodsThe proposed systematic review is registered with PROSPERO (International Prospective Register of Systematic Reviews). A systematic search of bibliographical databases, including Embase, PubMed, and Cochrane was conducted from inception to June 2023 to identify English-language human studies with adult patients receiving MSC therapy and optimal medical therapy for acute MI in comparison with respective controls. Article screening was performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Data on functional cardiac outcomes and major adverse cardiac events were extracted and analyzed as primary outcomes. ResultsLiterature search and article screening commenced in June 2023. Data extraction and analysis will be completed by October 2024. The findings will be synthesized and reported by the end of November 2024. ConclusionsThis systematic review and meta-analysis will summarize the best available updated evidence from published randomized controlled trials on the effects of MSC therapy for the treatment of acute MI. The findings of this systematic review and meta-analysis may shed light on the efficacy of MSC therapy in improving cardiac functional and structural parameters and reducing adverse cardiac events following acute MI. Trial RegistrationPROSPERO CRD42024522398; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=522398 International Registered Report Identifier (IRRID)DERR1-10.2196/60591https://www.researchprotocols.org/2025/1/e60591 |
| spellingShingle | Michael Vincent DiCaro Brianna Yee KaChon Lei Kavita Batra Buddhadeb Dawn Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis JMIR Research Protocols |
| title | Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis |
| title_full | Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis |
| title_fullStr | Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis |
| title_full_unstemmed | Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis |
| title_short | Mesenchymal Stem Cell Therapy for Acute Myocardial Infarction: Protocol for a Systematic Review and Meta-Analysis |
| title_sort | mesenchymal stem cell therapy for acute myocardial infarction protocol for a systematic review and meta analysis |
| url | https://www.researchprotocols.org/2025/1/e60591 |
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