Association between prenatal exposure to phthalate esters and blood pressure in children aged 3–7 years: A prospective cohort study
Background: An increasing number of animal studies have indicated that exposure to phthalate esters (PAEs) may cause high blood pressure. However, population-based evidence is limited, particularly for pregnant women and young children. Objective: To examine the correlation between prenatal exposure...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324016294 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856898976251904 |
|---|---|
| author | Zihao Wang Yu Zhang Wenwen Yang Mengfei Xu Beini Li Ping Wu Zhongqiang Cao Wei Wu |
| author_facet | Zihao Wang Yu Zhang Wenwen Yang Mengfei Xu Beini Li Ping Wu Zhongqiang Cao Wei Wu |
| author_sort | Zihao Wang |
| collection | DOAJ |
| description | Background: An increasing number of animal studies have indicated that exposure to phthalate esters (PAEs) may cause high blood pressure. However, population-based evidence is limited, particularly for pregnant women and young children. Objective: To examine the correlation between prenatal exposure to phthalate ester metabolites (mPAEs) and blood pressure in preschool children. Methods: In our cohort study, 497 pairs of mothers and children (aged 3–7 years) were enrolled at the Wuhan Maternal and Child Healthcare Hospital, Wuhan, China, between 2016 and 2017. Eight mPAEs were detected in the urine samples of pregnant women during the third trimester. Systolic (SBP) and diastolic blood pressure (DBP) were measured by physicians using an automated oscillometric sphygmomanometer and childhood hypertension was defined according to the American Academy of Pediatrics 2017 guidelines. Mixed-effects linear regression models were used to estimate the correlations between individual mPAEs and the SBP and DBP z-scores of preschoolers. Binary logistic regression models were used to examine the correlation between individual mPAEs and hypertension risk. A weighted quantile sum (WQS) regression was implemented to explore the correlation between mixed mPAEs and the SBP/DBP z-scores in children. Result: Monomethyl phthalate, monobutyl phthalate (MBP), monoethyl phthalate, mono(2-ethylhexyl) phthalate, mono(2-ethyl-5-hydroxyhexyl) phthalate and mono(2-ethyl-5-oxohexyl) phthalate were significantly positively correlated with increases in the SBP and DBP z-scores, whereas MBP was significantly correlated with hypertension risk, with an odds ratio of 1.695 (95 % confidence interval: 1.322, 2.173). Moreover, the WQS regression analyses revealed that MBP increased SBP (67.7 %) and DBP (80.8 %). Conclusions: The present study suggests that prenatal exposure to PAEs was positively correlated with increased blood pressure in pre-school children, and MBP is of particular concern because it contributed the most to the combined effect of PAE mixture on the risk of childhood hypertension. |
| format | Article |
| id | doaj-art-55a7573f68284e798be8fd066d476ff9 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-55a7573f68284e798be8fd066d476ff92025-02-12T05:29:41ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117553Association between prenatal exposure to phthalate esters and blood pressure in children aged 3–7 years: A prospective cohort studyZihao Wang0Yu Zhang1Wenwen Yang2Mengfei Xu3Beini Li4Ping Wu5Zhongqiang Cao6Wei Wu7School of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan 430065, China; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan 430065, ChinaMaternal and child health care hospital of Jiang’ an district, NO.68 Houhu South Road, Wuhan 430015, ChinaInstitute of Preventive Medicine Information, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, ChinaSchool of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan 430065, ChinaSchool of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan 430065, ChinaSchool of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan 430065, ChinaInstitute of Maternal and Children Health, Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430015, China; Correspondence to: Wuhan Children’s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.School of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan 430065, China; Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan 430065, China; Corresponding author at: School of Laboratory Medicine, Hubei University of Chinese Medicine, 16 Huangjia Lake West Road, Wuhan 430065, China.Background: An increasing number of animal studies have indicated that exposure to phthalate esters (PAEs) may cause high blood pressure. However, population-based evidence is limited, particularly for pregnant women and young children. Objective: To examine the correlation between prenatal exposure to phthalate ester metabolites (mPAEs) and blood pressure in preschool children. Methods: In our cohort study, 497 pairs of mothers and children (aged 3–7 years) were enrolled at the Wuhan Maternal and Child Healthcare Hospital, Wuhan, China, between 2016 and 2017. Eight mPAEs were detected in the urine samples of pregnant women during the third trimester. Systolic (SBP) and diastolic blood pressure (DBP) were measured by physicians using an automated oscillometric sphygmomanometer and childhood hypertension was defined according to the American Academy of Pediatrics 2017 guidelines. Mixed-effects linear regression models were used to estimate the correlations between individual mPAEs and the SBP and DBP z-scores of preschoolers. Binary logistic regression models were used to examine the correlation between individual mPAEs and hypertension risk. A weighted quantile sum (WQS) regression was implemented to explore the correlation between mixed mPAEs and the SBP/DBP z-scores in children. Result: Monomethyl phthalate, monobutyl phthalate (MBP), monoethyl phthalate, mono(2-ethylhexyl) phthalate, mono(2-ethyl-5-hydroxyhexyl) phthalate and mono(2-ethyl-5-oxohexyl) phthalate were significantly positively correlated with increases in the SBP and DBP z-scores, whereas MBP was significantly correlated with hypertension risk, with an odds ratio of 1.695 (95 % confidence interval: 1.322, 2.173). Moreover, the WQS regression analyses revealed that MBP increased SBP (67.7 %) and DBP (80.8 %). Conclusions: The present study suggests that prenatal exposure to PAEs was positively correlated with increased blood pressure in pre-school children, and MBP is of particular concern because it contributed the most to the combined effect of PAE mixture on the risk of childhood hypertension.http://www.sciencedirect.com/science/article/pii/S0147651324016294Phthalates esterFetal exposureCohort studyHypertension |
| spellingShingle | Zihao Wang Yu Zhang Wenwen Yang Mengfei Xu Beini Li Ping Wu Zhongqiang Cao Wei Wu Association between prenatal exposure to phthalate esters and blood pressure in children aged 3–7 years: A prospective cohort study Ecotoxicology and Environmental Safety Phthalates ester Fetal exposure Cohort study Hypertension |
| title | Association between prenatal exposure to phthalate esters and blood pressure in children aged 3–7 years: A prospective cohort study |
| title_full | Association between prenatal exposure to phthalate esters and blood pressure in children aged 3–7 years: A prospective cohort study |
| title_fullStr | Association between prenatal exposure to phthalate esters and blood pressure in children aged 3–7 years: A prospective cohort study |
| title_full_unstemmed | Association between prenatal exposure to phthalate esters and blood pressure in children aged 3–7 years: A prospective cohort study |
| title_short | Association between prenatal exposure to phthalate esters and blood pressure in children aged 3–7 years: A prospective cohort study |
| title_sort | association between prenatal exposure to phthalate esters and blood pressure in children aged 3 7 years a prospective cohort study |
| topic | Phthalates ester Fetal exposure Cohort study Hypertension |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324016294 |
| work_keys_str_mv | AT zihaowang associationbetweenprenatalexposuretophthalateestersandbloodpressureinchildrenaged37yearsaprospectivecohortstudy AT yuzhang associationbetweenprenatalexposuretophthalateestersandbloodpressureinchildrenaged37yearsaprospectivecohortstudy AT wenwenyang associationbetweenprenatalexposuretophthalateestersandbloodpressureinchildrenaged37yearsaprospectivecohortstudy AT mengfeixu associationbetweenprenatalexposuretophthalateestersandbloodpressureinchildrenaged37yearsaprospectivecohortstudy AT beinili associationbetweenprenatalexposuretophthalateestersandbloodpressureinchildrenaged37yearsaprospectivecohortstudy AT pingwu associationbetweenprenatalexposuretophthalateestersandbloodpressureinchildrenaged37yearsaprospectivecohortstudy AT zhongqiangcao associationbetweenprenatalexposuretophthalateestersandbloodpressureinchildrenaged37yearsaprospectivecohortstudy AT weiwu associationbetweenprenatalexposuretophthalateestersandbloodpressureinchildrenaged37yearsaprospectivecohortstudy |