Impact of sleep deprivation on colon cancer: Unraveling the KynA-P4HA2-HIF-1α axis in tumor lipid metabolism and metastasis

Impact of sleep deprivation on colon cancer: Unraveling the KynA-P4HA2-HIF-1α axis in tumor lipid metabolism and metastasis

Objective: There is growing evidence that sleep deprivation promotes cancer progression. In addition, colon cancer patients often experience sleep deprivation due to factors such as cancer pain and side effects of treatment. The occurrence of liver metastases is an important factor in the mortality...

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Bibliographic Details
Main Authors: Zuojie Peng, Jia Song, Wenzhong Zhu, Haijun Bao, Yuan Hu, Yongping Shi, Xukai Cheng, Mi Jiang, Feifei Fang, Jinhuang Chen, Xiaogang Shu
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Metabolism
Subjects:
Sleep deprivation
Colon cancer
Kynurenic acid
Liver metastasis
Lipid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S221287782500016X
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