The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout
ObjectiveThe study focuses on comparing the efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout.MethodsA prospective, randomized, open-labeled trial of men with gout and renal uric acid underexcretion was conducted. We randomly ass...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1469879/full |
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| author | Caiyu Zheng Caiyu Zheng Qingwen Tong Qingwen Tong Zhijun Zhang Chunmei Lin Zhiyi Wang Dongshu Kang Yanmei Lin Jianqing Tian |
| author_facet | Caiyu Zheng Caiyu Zheng Qingwen Tong Qingwen Tong Zhijun Zhang Chunmei Lin Zhiyi Wang Dongshu Kang Yanmei Lin Jianqing Tian |
| author_sort | Caiyu Zheng |
| collection | DOAJ |
| description | ObjectiveThe study focuses on comparing the efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout.MethodsA prospective, randomized, open-labeled trial of men with gout and renal uric acid underexcretion was conducted. We randomly assigned 100 patients to either low-dose febuxostat or low-dose benzbromarone for initial treatment. 43 patients with complete data were analyzed in this study. The analysis of medication Treatment effects, Period effects and Patient-Within-Sequence effects for different treatment options was performed by cross-test ANOVA.ResultThe cross-trial analysis revealed no significant differences in the magnitude of uric acid decline among the three groups after treatment. Similarly, there were no statistically significant differences in blood lipid levels, CRP, CA724, eGFR, and ALT among the three groups post-treatment. The null model without participant-specific benefits was a linear mixed model for ALT, AST, eGFR, TC, TG, LDL, UA, CRP, CA724, and 24-h uric acid with age, BMI, treatment period and treatment as fixed factors, and the intercept as a random factor by participant. The results indicated no significant differences on relevant indicators among the three treatment regimens.ConclusionOur study did not identify a difference in the efficacy of reducing uric acid excretion in gout patients when comparing conventional dose febuxostat and benzbromarone monotherapy versus low-dose combination therapy. |
| format | Article |
| id | doaj-art-56425b1208f84dbba408e43d5f023663 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-56425b1208f84dbba408e43d5f0236632025-02-07T06:49:21ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.14698791469879The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of goutCaiyu Zheng0Caiyu Zheng1Qingwen Tong2Qingwen Tong3Zhijun Zhang4Chunmei Lin5Zhiyi Wang6Dongshu Kang7Yanmei Lin8Jianqing Tian9Fujian Medical University Xiamen Humanity Hospital, Xiamen, ChinaSchool of Medicine, Xiamen University, Xiamen, ChinaFujian Medical University Xiamen Humanity Hospital, Xiamen, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaFujian Medical University Xiamen Humanity Hospital, Xiamen, ChinaFujian Medical University Xiamen Humanity Hospital, Xiamen, ChinaFujian Medical University Xiamen Humanity Hospital, Xiamen, ChinaFujian Medical University Xiamen Humanity Hospital, Xiamen, ChinaFujian Medical University Xiamen Humanity Hospital, Xiamen, ChinaFujian Medical University Xiamen Humanity Hospital, Xiamen, ChinaObjectiveThe study focuses on comparing the efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout.MethodsA prospective, randomized, open-labeled trial of men with gout and renal uric acid underexcretion was conducted. We randomly assigned 100 patients to either low-dose febuxostat or low-dose benzbromarone for initial treatment. 43 patients with complete data were analyzed in this study. The analysis of medication Treatment effects, Period effects and Patient-Within-Sequence effects for different treatment options was performed by cross-test ANOVA.ResultThe cross-trial analysis revealed no significant differences in the magnitude of uric acid decline among the three groups after treatment. Similarly, there were no statistically significant differences in blood lipid levels, CRP, CA724, eGFR, and ALT among the three groups post-treatment. The null model without participant-specific benefits was a linear mixed model for ALT, AST, eGFR, TC, TG, LDL, UA, CRP, CA724, and 24-h uric acid with age, BMI, treatment period and treatment as fixed factors, and the intercept as a random factor by participant. The results indicated no significant differences on relevant indicators among the three treatment regimens.ConclusionOur study did not identify a difference in the efficacy of reducing uric acid excretion in gout patients when comparing conventional dose febuxostat and benzbromarone monotherapy versus low-dose combination therapy.https://www.frontiersin.org/articles/10.3389/fmed.2025.1469879/fullfebuxostatbenzbromaronegout24-h uric aciduric acid |
| spellingShingle | Caiyu Zheng Caiyu Zheng Qingwen Tong Qingwen Tong Zhijun Zhang Chunmei Lin Zhiyi Wang Dongshu Kang Yanmei Lin Jianqing Tian The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout Frontiers in Medicine febuxostat benzbromarone gout 24-h uric acid uric acid |
| title | The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout |
| title_full | The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout |
| title_fullStr | The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout |
| title_full_unstemmed | The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout |
| title_short | The efficacy of a low-dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout |
| title_sort | efficacy of a low dose combination of febuxostat and benzbromarone versus each drug used alone for the treatment of gout |
| topic | febuxostat benzbromarone gout 24-h uric acid uric acid |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1469879/full |
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