Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis
Introduction: Considering that both long and short sleep duration may have an association with nonalcoholic fatty liver disease (NAFLD), in this meta-analysis, we analyzed the dose-response association between sleep duration and NAFLD along with meta-analyses of the differences in mean sleep duratio...
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Elsevier
2025-02-01
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| Series: | Preventive Medicine Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335525000075 |
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| author | Kasra Pirahesh Ali Zarrinnia Leila Nikniaz Zeinab Nikniaz |
| author_facet | Kasra Pirahesh Ali Zarrinnia Leila Nikniaz Zeinab Nikniaz |
| author_sort | Kasra Pirahesh |
| collection | DOAJ |
| description | Introduction: Considering that both long and short sleep duration may have an association with nonalcoholic fatty liver disease (NAFLD), in this meta-analysis, we analyzed the dose-response association between sleep duration and NAFLD along with meta-analyses of the differences in mean sleep duration between NAFLD patients and healthy controls, and linear meta-analysis of the association between sleep duration and NAFLD. Methods: PubMed (665 articles), Scopus (442 articles), and Web of Sciences (200 articles) were searched from inception until November 2023. Observational studies were included if they assess the association between sleep duration and NAFLD or compare the mean sleep duration between patients with NAFLD and healthy population. All studies done in humans without restriction on sex, age, and language were included. The methological quality of studies was assessed by Joanna Briggs Institute (JBI) tools. The meta-analysis was conducted using STATA. Results: Thirty-one studies that included 836,117 participants were included in this systematic review. The results indicated no significant differences between NAFLD patients and healthy controls regarding mean sleep duration [Mean difference: -7.08, 95 % CI: −20.10, 5.94]. The subgroup meta-analysis did not show any significant differences between groups. The long versus short sleep duration meta-analysis showed a significant association between sleep duration and NAFLD (OR: 0.8 [95 % CI, 0.74–0.91]). The results of the dose-response meta-analysis do not suggest a linear or nonlinear relationship between sleep duration and NAFLD (p-value = 0.9). Conclusion: The highest category of sleep duration was associated with a lower risk of NAFLD. However, no dose-response association was observed. |
| format | Article |
| id | doaj-art-5739429ee5ee4008a7333dee8d5ac62b |
| institution | Kabale University |
| issn | 2211-3355 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Preventive Medicine Reports |
| spelling | doaj-art-5739429ee5ee4008a7333dee8d5ac62b2025-02-08T05:00:14ZengElsevierPreventive Medicine Reports2211-33552025-02-0150102968Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysisKasra Pirahesh0Ali Zarrinnia1Leila Nikniaz2Zeinab Nikniaz3Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; School of Medicine, Tehran University of Medical Sciences, Tehran, IranStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Students` Scientific Research Center, Tehran University of Medical Sciences, Tehran, IranLiver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, IranTabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding author.Introduction: Considering that both long and short sleep duration may have an association with nonalcoholic fatty liver disease (NAFLD), in this meta-analysis, we analyzed the dose-response association between sleep duration and NAFLD along with meta-analyses of the differences in mean sleep duration between NAFLD patients and healthy controls, and linear meta-analysis of the association between sleep duration and NAFLD. Methods: PubMed (665 articles), Scopus (442 articles), and Web of Sciences (200 articles) were searched from inception until November 2023. Observational studies were included if they assess the association between sleep duration and NAFLD or compare the mean sleep duration between patients with NAFLD and healthy population. All studies done in humans without restriction on sex, age, and language were included. The methological quality of studies was assessed by Joanna Briggs Institute (JBI) tools. The meta-analysis was conducted using STATA. Results: Thirty-one studies that included 836,117 participants were included in this systematic review. The results indicated no significant differences between NAFLD patients and healthy controls regarding mean sleep duration [Mean difference: -7.08, 95 % CI: −20.10, 5.94]. The subgroup meta-analysis did not show any significant differences between groups. The long versus short sleep duration meta-analysis showed a significant association between sleep duration and NAFLD (OR: 0.8 [95 % CI, 0.74–0.91]). The results of the dose-response meta-analysis do not suggest a linear or nonlinear relationship between sleep duration and NAFLD (p-value = 0.9). Conclusion: The highest category of sleep duration was associated with a lower risk of NAFLD. However, no dose-response association was observed.http://www.sciencedirect.com/science/article/pii/S2211335525000075Sleep lengthFatty livermeta-analysisDose-responseNAFLD |
| spellingShingle | Kasra Pirahesh Ali Zarrinnia Leila Nikniaz Zeinab Nikniaz Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis Preventive Medicine Reports Sleep length Fatty liver meta-analysis Dose-response NAFLD |
| title | Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis |
| title_full | Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis |
| title_fullStr | Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis |
| title_full_unstemmed | Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis |
| title_short | Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis |
| title_sort | association between sleep duration and risk of nonalcoholic fatty liver disease a systematic review and meta analysis |
| topic | Sleep length Fatty liver meta-analysis Dose-response NAFLD |
| url | http://www.sciencedirect.com/science/article/pii/S2211335525000075 |
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