Vitamin B12, folate, and homocysteine levels in children and adolescents with obesity: a systematic review and meta-analysis
Background and aimsChildhood and adolescent obesity is a global public health concern. Obesity induces several metabolic disturbances. Several studies have explored the association of vitamin B12, folate, and homocysteine (Hcy) with obesity. This study aimed to synthesize the available evidence rega...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1481002/full |
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| author | Juan R. Ulloque-Badaracco Esteban A. Alarcon-Braga Enrique A. Hernandez-Bustamante Enrique A. Hernandez-Bustamante Beatrix M. Von-Koeller-Jones Miguel Huayta-Cortez Esduardo Saavedra-Custodio Percy Herrera-Añazco Vicente A. Benites-Zapata |
| author_facet | Juan R. Ulloque-Badaracco Esteban A. Alarcon-Braga Enrique A. Hernandez-Bustamante Enrique A. Hernandez-Bustamante Beatrix M. Von-Koeller-Jones Miguel Huayta-Cortez Esduardo Saavedra-Custodio Percy Herrera-Añazco Vicente A. Benites-Zapata |
| author_sort | Juan R. Ulloque-Badaracco |
| collection | DOAJ |
| description | Background and aimsChildhood and adolescent obesity is a global public health concern. Obesity induces several metabolic disturbances. Several studies have explored the association of vitamin B12, folate, and homocysteine (Hcy) with obesity. This study aimed to synthesize the available evidence regarding the differences in serum levels of vitamin B12, Hcy, and folate among children or adolescents with and without obesity.MethodsA random-effects meta-analysis using the Sidik-Jonkman method and corrected 95% confidence interval (CI) using the truncated Knapp-Hartung standard errors was used for all meta-analyses. Standardized mean difference (SMD) with the corresponding 95% CI was used as the only effect size. The Cochran’s Q test and the I2 statistic were used to evaluate between-study heterogeneity. Publication bias was assessed using funnel plots and the Egger test.ResultsTwenty studies were included with a combined study population of 7,791 patients. There were no significant differences between children/adolescents with and without obesity with respect to serum vitamin B12 levels (SMD: −0.24; 95% CI: −0.53 to 0.06; p > 0.05, I2 = 74.93%) and folate levels (SMD: −0.12; 95% CI: −0.29 to 0.06; p > 0.05, I2 = 19.6%). However, children/adolescents with obesity had significantly higher Hcy levels compared to counterparts without obesity (SMD: 0.77; 95% CI: 0.39 to 1.14; p < 0.001, I2 = 86.4%).ConclusionChildren and adolescents with obesity had higher Hcy levels than those without obesity. However, no significant differences were found for vitamin B12 and folate levels. Hcy may play a role in the development of obesity in this population. |
| format | Article |
| id | doaj-art-57969ab0effd482e937a6aef6017fc44 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-02-01 |
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| series | Frontiers in Public Health |
| spelling | doaj-art-57969ab0effd482e937a6aef6017fc442025-02-07T06:49:32ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-02-011310.3389/fpubh.2025.14810021481002Vitamin B12, folate, and homocysteine levels in children and adolescents with obesity: a systematic review and meta-analysisJuan R. Ulloque-Badaracco0Esteban A. Alarcon-Braga1Enrique A. Hernandez-Bustamante2Enrique A. Hernandez-Bustamante3Beatrix M. Von-Koeller-Jones4Miguel Huayta-Cortez5Esduardo Saavedra-Custodio6Percy Herrera-Añazco7Vicente A. Benites-Zapata8Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, PeruFacultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, PeruSociedad Científica de Estudiantes de Medicina de la Universidad Nacional de Trujillo, Trujillo, PeruGrupo Peruano de Investigación Epidemiológica, Unidad Para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, PeruFacultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, PeruFacultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, PeruFacultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, PeruFacultad de Ciencias de la Salud, Universidad Privada del Norte, Trujillo, PeruUnidad de Investigación Para la Generación y Síntesis de Evidencias en Salud, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, PeruBackground and aimsChildhood and adolescent obesity is a global public health concern. Obesity induces several metabolic disturbances. Several studies have explored the association of vitamin B12, folate, and homocysteine (Hcy) with obesity. This study aimed to synthesize the available evidence regarding the differences in serum levels of vitamin B12, Hcy, and folate among children or adolescents with and without obesity.MethodsA random-effects meta-analysis using the Sidik-Jonkman method and corrected 95% confidence interval (CI) using the truncated Knapp-Hartung standard errors was used for all meta-analyses. Standardized mean difference (SMD) with the corresponding 95% CI was used as the only effect size. The Cochran’s Q test and the I2 statistic were used to evaluate between-study heterogeneity. Publication bias was assessed using funnel plots and the Egger test.ResultsTwenty studies were included with a combined study population of 7,791 patients. There were no significant differences between children/adolescents with and without obesity with respect to serum vitamin B12 levels (SMD: −0.24; 95% CI: −0.53 to 0.06; p > 0.05, I2 = 74.93%) and folate levels (SMD: −0.12; 95% CI: −0.29 to 0.06; p > 0.05, I2 = 19.6%). However, children/adolescents with obesity had significantly higher Hcy levels compared to counterparts without obesity (SMD: 0.77; 95% CI: 0.39 to 1.14; p < 0.001, I2 = 86.4%).ConclusionChildren and adolescents with obesity had higher Hcy levels than those without obesity. However, no significant differences were found for vitamin B12 and folate levels. Hcy may play a role in the development of obesity in this population.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1481002/fullobesityvitamin B12folatehomocysteinemeta-analysis |
| spellingShingle | Juan R. Ulloque-Badaracco Esteban A. Alarcon-Braga Enrique A. Hernandez-Bustamante Enrique A. Hernandez-Bustamante Beatrix M. Von-Koeller-Jones Miguel Huayta-Cortez Esduardo Saavedra-Custodio Percy Herrera-Añazco Vicente A. Benites-Zapata Vitamin B12, folate, and homocysteine levels in children and adolescents with obesity: a systematic review and meta-analysis Frontiers in Public Health obesity vitamin B12 folate homocysteine meta-analysis |
| title | Vitamin B12, folate, and homocysteine levels in children and adolescents with obesity: a systematic review and meta-analysis |
| title_full | Vitamin B12, folate, and homocysteine levels in children and adolescents with obesity: a systematic review and meta-analysis |
| title_fullStr | Vitamin B12, folate, and homocysteine levels in children and adolescents with obesity: a systematic review and meta-analysis |
| title_full_unstemmed | Vitamin B12, folate, and homocysteine levels in children and adolescents with obesity: a systematic review and meta-analysis |
| title_short | Vitamin B12, folate, and homocysteine levels in children and adolescents with obesity: a systematic review and meta-analysis |
| title_sort | vitamin b12 folate and homocysteine levels in children and adolescents with obesity a systematic review and meta analysis |
| topic | obesity vitamin B12 folate homocysteine meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1481002/full |
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