Reassessing Nutritional Supplementation Program: The Impact of Maternal Vitamin B12 Levels on Feto-Maternal Outcomes
OBJECTIVES: In India, despite the high prevalence of vitamin B12 (vit B12) deficiency, the current public health policy focuses solely on iron and folic acid supplementation as a measure to prevent anaemia. Vit B12 is an important cofactor for enzymatic reactions related to DNA synthesis, folate, a...
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Medical Network
2023-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1403 |
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| author | Pranjali Dhume Reshu Rawal Ashish Vadhera Ankur Shah Madhusudan Dey Sunil Chawla Suyash Goel Simran Gilhotra Ankita Sharma |
| author_facet | Pranjali Dhume Reshu Rawal Ashish Vadhera Ankur Shah Madhusudan Dey Sunil Chawla Suyash Goel Simran Gilhotra Ankita Sharma |
| author_sort | Pranjali Dhume |
| collection | DOAJ |
| description |
OBJECTIVES: In India, despite the high prevalence of vitamin B12 (vit B12) deficiency, the current public health policy focuses solely on iron and folic acid supplementation as a measure to prevent anaemia. Vit B12 is an important cofactor for enzymatic reactions related to DNA synthesis, folate, and cell metabolism. While folate deficiency has been acknowledged in not only the prevention of neural tube defects and other adverse pregnancy outcomes, the effects of low vit B12 status have not been well defined. It is becoming recognized that there is a much higher prevalence of B12 deficiency than earlier suspected, and more of its effect on maternal and fetal health is being reported. The current study was planned as an observational study to correlate the effects of vit B12 deficiency with respect to various feto-maternal outcomes.
STUDY DESIGN: In this prospective cohort study a total of 300 antenatal women were screened for vit B12 levels in the late first trimester and were followed up to find out co-existent folic acid deficiency, development of pregnancy complications like anemia, gestational hypertension/pre-eclampsia, fetal growth restriction (FGR), second-trimester abortions, gestational diabetes mellitus (GDM) and preterm deliveries.
RESULTS: It was found that most of the women with low B12 levels were vegetarian and had co-existent folic acid deficiency. They had a statistically significant increase in the incidence of anemia, pre-eclampsia, gestational diabetes, (small for gestational age) SGA/FGR, and preterm births.
CONCLUSION: The study suggests that low levels of vit B12 increase the likelihood of adverse feto-maternal outcomes. Further research involving larger sample sizes is necessary to confirm these findings and determine if vit B12 supplementation should be included in pregnancy nutritional supplements, especially in vegetarian women.
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| format | Article |
| id | doaj-art-57fefea8f8a643029a0cd1ae00cf0aaf |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-57fefea8f8a643029a0cd1ae00cf0aaf2025-02-11T21:17:50ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182023-12-0129310.21613/GORM.2023.1403Reassessing Nutritional Supplementation Program: The Impact of Maternal Vitamin B12 Levels on Feto-Maternal OutcomesPranjali Dhume0Reshu Rawal1Ashish Vadhera2Ankur Shah3Madhusudan Dey4Sunil Chawla5Suyash Goel6Simran Gilhotra7Ankita Sharma8Armed Forces Medical Services IndiaArmed Forces Medical Services IndiaArmed Forces Medical Services IndiaArmed Forces Medical Services IndiaArmed Forces Medical Services IndiaArmed Forces Medical Services IndiaArmed Forces Medical Services IndiaESI PGIMER Model Hospital BasaidarapurArmed Forces Medical Services India OBJECTIVES: In India, despite the high prevalence of vitamin B12 (vit B12) deficiency, the current public health policy focuses solely on iron and folic acid supplementation as a measure to prevent anaemia. Vit B12 is an important cofactor for enzymatic reactions related to DNA synthesis, folate, and cell metabolism. While folate deficiency has been acknowledged in not only the prevention of neural tube defects and other adverse pregnancy outcomes, the effects of low vit B12 status have not been well defined. It is becoming recognized that there is a much higher prevalence of B12 deficiency than earlier suspected, and more of its effect on maternal and fetal health is being reported. The current study was planned as an observational study to correlate the effects of vit B12 deficiency with respect to various feto-maternal outcomes. STUDY DESIGN: In this prospective cohort study a total of 300 antenatal women were screened for vit B12 levels in the late first trimester and were followed up to find out co-existent folic acid deficiency, development of pregnancy complications like anemia, gestational hypertension/pre-eclampsia, fetal growth restriction (FGR), second-trimester abortions, gestational diabetes mellitus (GDM) and preterm deliveries. RESULTS: It was found that most of the women with low B12 levels were vegetarian and had co-existent folic acid deficiency. They had a statistically significant increase in the incidence of anemia, pre-eclampsia, gestational diabetes, (small for gestational age) SGA/FGR, and preterm births. CONCLUSION: The study suggests that low levels of vit B12 increase the likelihood of adverse feto-maternal outcomes. Further research involving larger sample sizes is necessary to confirm these findings and determine if vit B12 supplementation should be included in pregnancy nutritional supplements, especially in vegetarian women. https://gorm.com.tr/index.php/GORM/article/view/1403B12 deficiencyMaternal nutrition Vit B12 Feto-maternal outcomeVit B12 supplement |
| spellingShingle | Pranjali Dhume Reshu Rawal Ashish Vadhera Ankur Shah Madhusudan Dey Sunil Chawla Suyash Goel Simran Gilhotra Ankita Sharma Reassessing Nutritional Supplementation Program: The Impact of Maternal Vitamin B12 Levels on Feto-Maternal Outcomes Gynecology Obstetrics & Reproductive Medicine B12 deficiency Maternal nutrition Vit B12 Feto-maternal outcome Vit B12 supplement |
| title | Reassessing Nutritional Supplementation Program: The Impact of Maternal Vitamin B12 Levels on Feto-Maternal Outcomes |
| title_full | Reassessing Nutritional Supplementation Program: The Impact of Maternal Vitamin B12 Levels on Feto-Maternal Outcomes |
| title_fullStr | Reassessing Nutritional Supplementation Program: The Impact of Maternal Vitamin B12 Levels on Feto-Maternal Outcomes |
| title_full_unstemmed | Reassessing Nutritional Supplementation Program: The Impact of Maternal Vitamin B12 Levels on Feto-Maternal Outcomes |
| title_short | Reassessing Nutritional Supplementation Program: The Impact of Maternal Vitamin B12 Levels on Feto-Maternal Outcomes |
| title_sort | reassessing nutritional supplementation program the impact of maternal vitamin b12 levels on feto maternal outcomes |
| topic | B12 deficiency Maternal nutrition Vit B12 Feto-maternal outcome Vit B12 supplement |
| url | https://gorm.com.tr/index.php/GORM/article/view/1403 |
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