Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress
Environmental arsenic contamination is a serious issue that cannot be ignored, since arsenic levels in drinking water frequently exceed safety standards, and there is an increased prevalence of Helicobacter pylori (H. pylori) infection. This results in an increasing population at risk of simultaneou...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015884 |
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| author | Linmin Zhong Qiling Yang Yiming Shao Shanwen Hu Lianxian Guo |
| author_facet | Linmin Zhong Qiling Yang Yiming Shao Shanwen Hu Lianxian Guo |
| author_sort | Linmin Zhong |
| collection | DOAJ |
| description | Environmental arsenic contamination is a serious issue that cannot be ignored, since arsenic levels in drinking water frequently exceed safety standards, and there is an increased prevalence of Helicobacter pylori (H. pylori) infection. This results in an increasing population at risk of simultaneous exposure to both harmful agents, yet whether a synergistic interaction exists between them remains unclear. Therefore, this study aims to investigate the combined effects and underlying pathogenic mechanisms of concurrent exposure to these two hazardous factors by establishing a mouse model that is infected with H. pylori and exposed to inorganic arsenic through drinking water. Analysis of intestinal flora revealed significant alterations in the composition, relative abundance (Akkermansia, Faecalibaculum, Ilieibacterium, etc.), and metabolic potential of the intestinal microflora (amino acid metabolism and energy metabolism) in the combinatory exposure group. Non-targeted metabolomics analysis identified that the combinatory exposure group exhibited greater fluctuations in metabolite content, particularly in triacylglycerol, fatty-acid, peptide and amino acid. Moreover, H. pylori infection and arsenic exposure had increased levels of metabolites associated with the intestinal microbiota in their livers (4-Ethylphenyl sulfate and Phenylacetylglycine). Further analysis revealed significant correlations between changes in the intestinal flora and alterations in liver metabolic profiles. Herein, we hypothesize that H. pylori infection may exacerbate the intestinal flora imbalance and hepatic metabolic disturbances caused by arsenic exposure, which may disrupt enterohepatic homeostasis and potentially increase biological susceptibility to heavy metal toxicity. |
| format | Article |
| id | doaj-art-5877cda6a5c14bfb957bf3ee012a15e0 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-5877cda6a5c14bfb957bf3ee012a15e02025-02-12T05:29:24ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117512Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stressLinmin Zhong0Qiling Yang1Yiming Shao2Shanwen Hu3Lianxian Guo4Dongguan Key Laboratory of Public Health Laboratory Science, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou 350122, ChinaDongguan Key Laboratory of Sepsis Translational Medicine, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Health Inspection and Quarantine, School of Public Health, Fujian Medical University, Fuzhou 350122, ChinaDongguan Key Laboratory of Public Health Laboratory Science, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan 523808, China; Corresponding author.Environmental arsenic contamination is a serious issue that cannot be ignored, since arsenic levels in drinking water frequently exceed safety standards, and there is an increased prevalence of Helicobacter pylori (H. pylori) infection. This results in an increasing population at risk of simultaneous exposure to both harmful agents, yet whether a synergistic interaction exists between them remains unclear. Therefore, this study aims to investigate the combined effects and underlying pathogenic mechanisms of concurrent exposure to these two hazardous factors by establishing a mouse model that is infected with H. pylori and exposed to inorganic arsenic through drinking water. Analysis of intestinal flora revealed significant alterations in the composition, relative abundance (Akkermansia, Faecalibaculum, Ilieibacterium, etc.), and metabolic potential of the intestinal microflora (amino acid metabolism and energy metabolism) in the combinatory exposure group. Non-targeted metabolomics analysis identified that the combinatory exposure group exhibited greater fluctuations in metabolite content, particularly in triacylglycerol, fatty-acid, peptide and amino acid. Moreover, H. pylori infection and arsenic exposure had increased levels of metabolites associated with the intestinal microbiota in their livers (4-Ethylphenyl sulfate and Phenylacetylglycine). Further analysis revealed significant correlations between changes in the intestinal flora and alterations in liver metabolic profiles. Herein, we hypothesize that H. pylori infection may exacerbate the intestinal flora imbalance and hepatic metabolic disturbances caused by arsenic exposure, which may disrupt enterohepatic homeostasis and potentially increase biological susceptibility to heavy metal toxicity.http://www.sciencedirect.com/science/article/pii/S0147651324015884Bacterial infectionEnvironmental pollutionMicrobiomicsMetabolomics |
| spellingShingle | Linmin Zhong Qiling Yang Yiming Shao Shanwen Hu Lianxian Guo Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress Ecotoxicology and Environmental Safety Bacterial infection Environmental pollution Microbiomics Metabolomics |
| title | Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress |
| title_full | Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress |
| title_fullStr | Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress |
| title_full_unstemmed | Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress |
| title_short | Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress |
| title_sort | helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress |
| topic | Bacterial infection Environmental pollution Microbiomics Metabolomics |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015884 |
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