Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection.
With the rapid increase in the number of implant operations, the incidence of bone infections has increased. Methicillin-resistant Staphylococcus aureus (S. aureus) and other emerging fully drug-resistant strains make the management of bone infections even more challenging. Bone infections are mainl...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1012896 |
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| _version_ | 1825206787256614912 |
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| author | Zhihao Chen Qiyuan Jin Jinqi Zhong Zonggang Xie Qi Chen Liubing Li Jijie Li Chenhao Zhao Junfeng Wang Xiaoying Tang Mingxiao Han Ru Li Ziyuan Li Zelei Tong Min Wang Hong Du Haifang Zhang |
| author_facet | Zhihao Chen Qiyuan Jin Jinqi Zhong Zonggang Xie Qi Chen Liubing Li Jijie Li Chenhao Zhao Junfeng Wang Xiaoying Tang Mingxiao Han Ru Li Ziyuan Li Zelei Tong Min Wang Hong Du Haifang Zhang |
| author_sort | Zhihao Chen |
| collection | DOAJ |
| description | With the rapid increase in the number of implant operations, the incidence of bone infections has increased. Methicillin-resistant Staphylococcus aureus (S. aureus) and other emerging fully drug-resistant strains make the management of bone infections even more challenging. Bone infections are mainly caused by S. aureus and require extensive surgical intervention and long-term antibiotic therapy. The host autophagy response is critical to the elimination of S. aureus infections. In this study, we demonstrate that a circular RNA (circRNA), circSyk, is a potential biological target for the treatment of S. aureus-induced bone infection. Most importantly, S. aureus regulates circSyk to block autophagy and promote bone destruction via the circSyk/miR-5106/Sik3 axis in a nonclassical pathway, which is involved in the S. aureus infection process through a competitive endogenous RNA network. In summary, this study proposes a novel perspective on the immune escape of S. aureus in bone infections, based on circRNA. |
| format | Article |
| id | doaj-art-59974331ac9542e39d47326bdf22360b |
| institution | Kabale University |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-59974331ac9542e39d47326bdf22360b2025-02-07T05:30:30ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742025-01-01211e101289610.1371/journal.ppat.1012896Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection.Zhihao ChenQiyuan JinJinqi ZhongZonggang XieQi ChenLiubing LiJijie LiChenhao ZhaoJunfeng WangXiaoying TangMingxiao HanRu LiZiyuan LiZelei TongMin WangHong DuHaifang ZhangWith the rapid increase in the number of implant operations, the incidence of bone infections has increased. Methicillin-resistant Staphylococcus aureus (S. aureus) and other emerging fully drug-resistant strains make the management of bone infections even more challenging. Bone infections are mainly caused by S. aureus and require extensive surgical intervention and long-term antibiotic therapy. The host autophagy response is critical to the elimination of S. aureus infections. In this study, we demonstrate that a circular RNA (circRNA), circSyk, is a potential biological target for the treatment of S. aureus-induced bone infection. Most importantly, S. aureus regulates circSyk to block autophagy and promote bone destruction via the circSyk/miR-5106/Sik3 axis in a nonclassical pathway, which is involved in the S. aureus infection process through a competitive endogenous RNA network. In summary, this study proposes a novel perspective on the immune escape of S. aureus in bone infections, based on circRNA.https://doi.org/10.1371/journal.ppat.1012896 |
| spellingShingle | Zhihao Chen Qiyuan Jin Jinqi Zhong Zonggang Xie Qi Chen Liubing Li Jijie Li Chenhao Zhao Junfeng Wang Xiaoying Tang Mingxiao Han Ru Li Ziyuan Li Zelei Tong Min Wang Hong Du Haifang Zhang Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection. PLoS Pathogens |
| title | Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection. |
| title_full | Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection. |
| title_fullStr | Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection. |
| title_full_unstemmed | Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection. |
| title_short | Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection. |
| title_sort | staphylococcus aureus blocks host autophagy through circsyk mir 5106 sik3 axis to promote progression of bone infection |
| url | https://doi.org/10.1371/journal.ppat.1012896 |
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