Is insomnia a risk factor for new-onset asthma? A population-based study in Taiwan
Objectives To determine whether insomnia at baseline is a risk factor for new-onset asthma.Methods We recruited 48 871 patients with insomnia (insomnia group) newly diagnosed between 2002 and 2007, and 97 742 matched controls without insomnia (control group) from Taiwan’s Longitudinal Health Insuran...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2017-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/7/11/e018714.full |
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| author | Shih-Feng Weng Chih-Cheng Lai Yu-Chieh Lin Chih-Chiang Chien Chin-Ming Chen Shyh-Ren Chiang Chung-Han Ho Kuo-Chen Cheng |
| author_facet | Shih-Feng Weng Chih-Cheng Lai Yu-Chieh Lin Chih-Chiang Chien Chin-Ming Chen Shyh-Ren Chiang Chung-Han Ho Kuo-Chen Cheng |
| author_sort | Shih-Feng Weng |
| collection | DOAJ |
| description | Objectives To determine whether insomnia at baseline is a risk factor for new-onset asthma.Methods We recruited 48 871 patients with insomnia (insomnia group) newly diagnosed between 2002 and 2007, and 97 742 matched controls without insomnia (control group) from Taiwan’s Longitudinal Health Insurance Database 2000. All of the patients were followed up for 4 years to see whether new-onset asthma developed. Patients with previous asthma or insomnia were excluded. The Poisson regression was used to estimate the incidence rate ratios (IRRs) and 95% CIs of asthma. Cox proportional hazard regression was used to calculate the risk of asthma between the two groups.Results After a 4-year follow-up, 424 patients in the insomnia group and 409 in the control group developed asthma. The incidence rate of asthma was significantly higher in the insomnia group (22.01vs10.57 per 10 000 person-years). Patients with insomnia have a higher risk of developing new-onset asthma during the 4-year follow-up (HR: 2.08, 95% CI 1.82 to 2.39). The difference remained significant after adjustment (adjusted HR: 1.89, 95% CI 1.64 to 2.17).Conclusions This large population-based study suggests that insomnia at baseline is a risk factor for developing asthma. |
| format | Article |
| id | doaj-art-5ab93eb784e0409fad45c2a287a1614f |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2017-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-5ab93eb784e0409fad45c2a287a1614f2025-02-11T15:15:11ZengBMJ Publishing GroupBMJ Open2044-60552017-11-0171110.1136/bmjopen-2017-018714Is insomnia a risk factor for new-onset asthma? A population-based study in TaiwanShih-Feng Weng0Chih-Cheng Lai1Yu-Chieh Lin2Chih-Chiang Chien3Chin-Ming Chen4Shyh-Ren Chiang5Chung-Han Ho6Kuo-Chen Cheng7Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan5 Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan1 Department of Family Medicine, Jiannren Hospital, Kaohsiung, Taiwan3 Department of Internal Medicine, Chi Mei Medical Center, Yung Kang, Tainan, Taiwan4 Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan3 Department of Internal Medicine, Chi Mei Medical Center, Yung Kang, Tainan, TaiwanMedical Research, Chi Mei Medical Center, Tainan, Taiwan3 Department of Internal Medicine, Chi Mei Medical Center, Yung Kang, Tainan, TaiwanObjectives To determine whether insomnia at baseline is a risk factor for new-onset asthma.Methods We recruited 48 871 patients with insomnia (insomnia group) newly diagnosed between 2002 and 2007, and 97 742 matched controls without insomnia (control group) from Taiwan’s Longitudinal Health Insurance Database 2000. All of the patients were followed up for 4 years to see whether new-onset asthma developed. Patients with previous asthma or insomnia were excluded. The Poisson regression was used to estimate the incidence rate ratios (IRRs) and 95% CIs of asthma. Cox proportional hazard regression was used to calculate the risk of asthma between the two groups.Results After a 4-year follow-up, 424 patients in the insomnia group and 409 in the control group developed asthma. The incidence rate of asthma was significantly higher in the insomnia group (22.01vs10.57 per 10 000 person-years). Patients with insomnia have a higher risk of developing new-onset asthma during the 4-year follow-up (HR: 2.08, 95% CI 1.82 to 2.39). The difference remained significant after adjustment (adjusted HR: 1.89, 95% CI 1.64 to 2.17).Conclusions This large population-based study suggests that insomnia at baseline is a risk factor for developing asthma.https://bmjopen.bmj.com/content/7/11/e018714.full |
| spellingShingle | Shih-Feng Weng Chih-Cheng Lai Yu-Chieh Lin Chih-Chiang Chien Chin-Ming Chen Shyh-Ren Chiang Chung-Han Ho Kuo-Chen Cheng Is insomnia a risk factor for new-onset asthma? A population-based study in Taiwan BMJ Open |
| title | Is insomnia a risk factor for new-onset asthma? A population-based study in Taiwan |
| title_full | Is insomnia a risk factor for new-onset asthma? A population-based study in Taiwan |
| title_fullStr | Is insomnia a risk factor for new-onset asthma? A population-based study in Taiwan |
| title_full_unstemmed | Is insomnia a risk factor for new-onset asthma? A population-based study in Taiwan |
| title_short | Is insomnia a risk factor for new-onset asthma? A population-based study in Taiwan |
| title_sort | is insomnia a risk factor for new onset asthma a population based study in taiwan |
| url | https://bmjopen.bmj.com/content/7/11/e018714.full |
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