Multimodal mismatch responses in mouse auditory cortex
Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual sensory input, primary sensory areas of cortex have been shown to compute sensorimotor prediction errors. How prediction errors in one sensory modality influence the comp...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2025-02-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/95398 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860043358928896 |
|---|---|
| author | Magdalena Solyga Georg B Keller |
| author_facet | Magdalena Solyga Georg B Keller |
| author_sort | Magdalena Solyga |
| collection | DOAJ |
| description | Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual sensory input, primary sensory areas of cortex have been shown to compute sensorimotor prediction errors. How prediction errors in one sensory modality influence the computation of prediction errors in another modality is still unclear. To investigate multimodal prediction errors in mouse auditory cortex, we used a virtual environment to experimentally couple running to both self-generated auditory and visual feedback. Using two-photon microscopy, we first characterized responses of layer 2/3 (L2/3) neurons to sounds, visual stimuli, and running onsets and found responses to all three stimuli. Probing responses evoked by audiomotor (AM) mismatches, we found that they closely resemble visuomotor (VM) mismatch responses in visual cortex (V1). Finally, testing for cross modal influence on AM mismatch responses by coupling both sound amplitude and visual flow speed to the speed of running, we found that AM mismatch responses were amplified when paired with concurrent VM mismatches. Our results demonstrate that multimodal and non-hierarchical interactions shape prediction error responses in cortical L2/3. |
| format | Article |
| id | doaj-art-5b2f534550cc4ed18abe3b9bc73b92c1 |
| institution | Kabale University |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-5b2f534550cc4ed18abe3b9bc73b92c12025-02-10T16:32:08ZengeLife Sciences Publications LtdeLife2050-084X2025-02-011310.7554/eLife.95398Multimodal mismatch responses in mouse auditory cortexMagdalena Solyga0https://orcid.org/0000-0003-2969-2963Georg B Keller1https://orcid.org/0000-0002-1401-0117Friedrich Miescher Institute for Biomedical Research, Basel, SwitzerlandFriedrich Miescher Institute for Biomedical Research, Basel, Switzerland; Faculty of Science, University of Basel, Basel, SwitzerlandOur movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual sensory input, primary sensory areas of cortex have been shown to compute sensorimotor prediction errors. How prediction errors in one sensory modality influence the computation of prediction errors in another modality is still unclear. To investigate multimodal prediction errors in mouse auditory cortex, we used a virtual environment to experimentally couple running to both self-generated auditory and visual feedback. Using two-photon microscopy, we first characterized responses of layer 2/3 (L2/3) neurons to sounds, visual stimuli, and running onsets and found responses to all three stimuli. Probing responses evoked by audiomotor (AM) mismatches, we found that they closely resemble visuomotor (VM) mismatch responses in visual cortex (V1). Finally, testing for cross modal influence on AM mismatch responses by coupling both sound amplitude and visual flow speed to the speed of running, we found that AM mismatch responses were amplified when paired with concurrent VM mismatches. Our results demonstrate that multimodal and non-hierarchical interactions shape prediction error responses in cortical L2/3.https://elifesciences.org/articles/95398predictive processinglayer 2/3 neuronssensorimotor mismatch responses |
| spellingShingle | Magdalena Solyga Georg B Keller Multimodal mismatch responses in mouse auditory cortex eLife predictive processing layer 2/3 neurons sensorimotor mismatch responses |
| title | Multimodal mismatch responses in mouse auditory cortex |
| title_full | Multimodal mismatch responses in mouse auditory cortex |
| title_fullStr | Multimodal mismatch responses in mouse auditory cortex |
| title_full_unstemmed | Multimodal mismatch responses in mouse auditory cortex |
| title_short | Multimodal mismatch responses in mouse auditory cortex |
| title_sort | multimodal mismatch responses in mouse auditory cortex |
| topic | predictive processing layer 2/3 neurons sensorimotor mismatch responses |
| url | https://elifesciences.org/articles/95398 |
| work_keys_str_mv | AT magdalenasolyga multimodalmismatchresponsesinmouseauditorycortex AT georgbkeller multimodalmismatchresponsesinmouseauditorycortex |