Role of stem cells on motor function recovery in stroke patients: systematic review
Abstract Background The effectiveness of stem cell (SC) therapy for motor recovery in stroke patients remains debated within the scientific community. Aim/Objective This study aims to conduct a comprehensive systematic review and meta-analysis to evaluate the therapeutic potential of SC administrati...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2025-02-01
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| Series: | Egyptian Journal of Neurosurgery |
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| Online Access: | https://doi.org/10.1186/s41984-025-00352-6 |
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| author | Babita Raghuwanshi Suresh K. Thanneeru Roshan Chanchalani Sumit Raj Pradeep Chouksey Md Yunus Amit Agrawal |
| author_facet | Babita Raghuwanshi Suresh K. Thanneeru Roshan Chanchalani Sumit Raj Pradeep Chouksey Md Yunus Amit Agrawal |
| author_sort | Babita Raghuwanshi |
| collection | DOAJ |
| description | Abstract Background The effectiveness of stem cell (SC) therapy for motor recovery in stroke patients remains debated within the scientific community. Aim/Objective This study aims to conduct a comprehensive systematic review and meta-analysis to evaluate the therapeutic potential of SC administration for motor recovery in stroke. Methods A thorough search was performed on major electronic databases—PubMed, Scopus, ScienceDirect, and Cochrane—until August 15, 2023. Studies were selected based on predefined inclusion and exclusion criteria to ensure methodological rigor and relevance. Results The initial search identified a substantial number of studies. After applying the selection criteria, a final set of eligible studies was reviewed. The extracted data covered various outcome measures related to motor recovery in stroke patients. Conclusions Although some studies suggest the potential efficacy of stem cell therapy for motor recovery in stroke patients, the evidence lacks consistency. Future well-designed, robust randomized controlled trials are necessary to evaluate the efficacy, safety, and ethical implications of stem cell therapy for motor recovery in stroke patients. |
| format | Article |
| id | doaj-art-5b32459b4d124c6b83f4cb4b5b66e58d |
| institution | Kabale University |
| issn | 2520-8225 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Neurosurgery |
| spelling | doaj-art-5b32459b4d124c6b83f4cb4b5b66e58d2025-02-09T12:25:14ZengSpringerOpenEgyptian Journal of Neurosurgery2520-82252025-02-014011810.1186/s41984-025-00352-6Role of stem cells on motor function recovery in stroke patients: systematic reviewBabita Raghuwanshi0Suresh K. Thanneeru1Roshan Chanchalani2Sumit Raj3Pradeep Chouksey4Md Yunus5Amit Agrawal6Department of Blood Bank and Transfusion Medicine, All India Institute of Medical SciencesDepartment of Paediatric Surgery, All India Institute of Medical SciencesDepartment of Paediatric Surgery, All India Institute of Medical SciencesDepartment of Neurosurgery, All India Institute of Medical SciencesDepartment of Neurosurgery, All India Institute of Medical SciencesDepartment of Trauma and Emergency Medicine, All India Institute of Medical SciencesDepartment of Neurosurgery, All India Institute of Medical SciencesAbstract Background The effectiveness of stem cell (SC) therapy for motor recovery in stroke patients remains debated within the scientific community. Aim/Objective This study aims to conduct a comprehensive systematic review and meta-analysis to evaluate the therapeutic potential of SC administration for motor recovery in stroke. Methods A thorough search was performed on major electronic databases—PubMed, Scopus, ScienceDirect, and Cochrane—until August 15, 2023. Studies were selected based on predefined inclusion and exclusion criteria to ensure methodological rigor and relevance. Results The initial search identified a substantial number of studies. After applying the selection criteria, a final set of eligible studies was reviewed. The extracted data covered various outcome measures related to motor recovery in stroke patients. Conclusions Although some studies suggest the potential efficacy of stem cell therapy for motor recovery in stroke patients, the evidence lacks consistency. Future well-designed, robust randomized controlled trials are necessary to evaluate the efficacy, safety, and ethical implications of stem cell therapy for motor recovery in stroke patients.https://doi.org/10.1186/s41984-025-00352-6StrokeMesenchymal stem cellMotor recoveryfMRIBiomarkerCell therapy |
| spellingShingle | Babita Raghuwanshi Suresh K. Thanneeru Roshan Chanchalani Sumit Raj Pradeep Chouksey Md Yunus Amit Agrawal Role of stem cells on motor function recovery in stroke patients: systematic review Egyptian Journal of Neurosurgery Stroke Mesenchymal stem cell Motor recovery fMRI Biomarker Cell therapy |
| title | Role of stem cells on motor function recovery in stroke patients: systematic review |
| title_full | Role of stem cells on motor function recovery in stroke patients: systematic review |
| title_fullStr | Role of stem cells on motor function recovery in stroke patients: systematic review |
| title_full_unstemmed | Role of stem cells on motor function recovery in stroke patients: systematic review |
| title_short | Role of stem cells on motor function recovery in stroke patients: systematic review |
| title_sort | role of stem cells on motor function recovery in stroke patients systematic review |
| topic | Stroke Mesenchymal stem cell Motor recovery fMRI Biomarker Cell therapy |
| url | https://doi.org/10.1186/s41984-025-00352-6 |
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