Value of transabdominal ultrasonography for diagnosing functional constipation in children: a systematic review and meta-analysis
Transabdominal ultrasonography is increasingly used as a novel modality for detecting pediatric functional constipation (FC). This systematic review and meta-analysis aimed to assess the diagnostic parameters of FC including rectal diameter (RD) and anterior rectal wall thickness. A systematic searc...
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2025-02-01
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| Series: | Clinical and Experimental Pediatrics |
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| Online Access: | http://www.e-cep.org/upload/pdf/cep-2024-00927.pdf |
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| author | Duc Long Tran Phu Nguyen Trong Tran Paweena Susantitaphong Phichayut Phinyo Palittiya Sintusek |
| author_facet | Duc Long Tran Phu Nguyen Trong Tran Paweena Susantitaphong Phichayut Phinyo Palittiya Sintusek |
| author_sort | Duc Long Tran |
| collection | DOAJ |
| description | Transabdominal ultrasonography is increasingly used as a novel modality for detecting pediatric functional constipation (FC). This systematic review and meta-analysis aimed to assess the diagnostic parameters of FC including rectal diameter (RD) and anterior rectal wall thickness. A systematic search was conducted of the Ovid MEDLINE, Embase, Scopus, and PubMed databases through September 29, 2023, to identify studies comparing RD and anterior wall thickness using transabdominal ultrasonography in children with versus without FC. Metaanalyses were performed using random-effects models to calculate the weighted mean differences (MDs) in RD and anterior wall thickness. Comprehensive Meta-Analysis ver. 3, R, and Review Manager ver. 5.4.1 software were used to assess the optimal cutoff, sensitivity, specificity, and area under the curve (AUC). Fourteen studies involving 1,255 children (mean age, 6.21±2.3 years) were included. The mean RD was significantly larger in constipated children versus controls (MD, 10.35 mm; 95% confidence interval [CI], 6.97–13.74; P<0.001; I2=94%). A meta-regression showed no significant effects of age, weight, or height on RD. An optimal RD cutoff point of 31 mm was suggested by a pooled analysis with an AUC of 0.86 (95% CI, 0.8–0.91; P<0.001), sensitivity of 0.75 (95% CI, 0.59–0.86), and specificity of 0.84 (95% CI, 0.68–0.93). The mean anterior rectal wall thickness was greater among constipated children than among controls (MD, 0.44; 95% CI, -0.26 to 1.13; P=0.22), but this difference was not statistically significant. RD measured using transabdominal ultrasonography with a cutoff point of 31 mm exhibited good diagnostic accuracy for diagnosing FC in children. |
| format | Article |
| id | doaj-art-5c089b36e388424c8e66180cb2c3569e |
| institution | Kabale University |
| issn | 2713-4148 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj-art-5c089b36e388424c8e66180cb2c3569e2025-02-07T07:38:39ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482025-02-0168212713510.3345/cep.2024.0092720125555753Value of transabdominal ultrasonography for diagnosing functional constipation in children: a systematic review and meta-analysisDuc Long Tran0Phu Nguyen Trong Tran1Paweena Susantitaphong2Phichayut Phinyo3Palittiya Sintusek4 Clinical Sciences Program, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Clinical Sciences Program, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Division of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, The Thai Red Cross Society, Bangkok, Thailand Center for Clinical Epidemiology and Clinical Statistics, Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand Center of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology (TPGHAI), Division of Gastroenterology, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, ThailandTransabdominal ultrasonography is increasingly used as a novel modality for detecting pediatric functional constipation (FC). This systematic review and meta-analysis aimed to assess the diagnostic parameters of FC including rectal diameter (RD) and anterior rectal wall thickness. A systematic search was conducted of the Ovid MEDLINE, Embase, Scopus, and PubMed databases through September 29, 2023, to identify studies comparing RD and anterior wall thickness using transabdominal ultrasonography in children with versus without FC. Metaanalyses were performed using random-effects models to calculate the weighted mean differences (MDs) in RD and anterior wall thickness. Comprehensive Meta-Analysis ver. 3, R, and Review Manager ver. 5.4.1 software were used to assess the optimal cutoff, sensitivity, specificity, and area under the curve (AUC). Fourteen studies involving 1,255 children (mean age, 6.21±2.3 years) were included. The mean RD was significantly larger in constipated children versus controls (MD, 10.35 mm; 95% confidence interval [CI], 6.97–13.74; P<0.001; I2=94%). A meta-regression showed no significant effects of age, weight, or height on RD. An optimal RD cutoff point of 31 mm was suggested by a pooled analysis with an AUC of 0.86 (95% CI, 0.8–0.91; P<0.001), sensitivity of 0.75 (95% CI, 0.59–0.86), and specificity of 0.84 (95% CI, 0.68–0.93). The mean anterior rectal wall thickness was greater among constipated children than among controls (MD, 0.44; 95% CI, -0.26 to 1.13; P=0.22), but this difference was not statistically significant. RD measured using transabdominal ultrasonography with a cutoff point of 31 mm exhibited good diagnostic accuracy for diagnosing FC in children.http://www.e-cep.org/upload/pdf/cep-2024-00927.pdfchildfunctional constipationultrasonographymeta-analysisrectal diameter |
| spellingShingle | Duc Long Tran Phu Nguyen Trong Tran Paweena Susantitaphong Phichayut Phinyo Palittiya Sintusek Value of transabdominal ultrasonography for diagnosing functional constipation in children: a systematic review and meta-analysis Clinical and Experimental Pediatrics child functional constipation ultrasonography meta-analysis rectal diameter |
| title | Value of transabdominal ultrasonography for diagnosing functional constipation in children: a systematic review and meta-analysis |
| title_full | Value of transabdominal ultrasonography for diagnosing functional constipation in children: a systematic review and meta-analysis |
| title_fullStr | Value of transabdominal ultrasonography for diagnosing functional constipation in children: a systematic review and meta-analysis |
| title_full_unstemmed | Value of transabdominal ultrasonography for diagnosing functional constipation in children: a systematic review and meta-analysis |
| title_short | Value of transabdominal ultrasonography for diagnosing functional constipation in children: a systematic review and meta-analysis |
| title_sort | value of transabdominal ultrasonography for diagnosing functional constipation in children a systematic review and meta analysis |
| topic | child functional constipation ultrasonography meta-analysis rectal diameter |
| url | http://www.e-cep.org/upload/pdf/cep-2024-00927.pdf |
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