A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community
Background Information: Diabetes is a serious global health issue that is particularly common in East Africa. Lifestyle factors influence the incidence, mortality, and morbidity of diabetes. Medicinal plants have phytochemicals with anti-diabetic properties. Purpose: This systematic review assesses...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266703132400191X |
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| author | Nancy Bonareri Mitaki Ilemobayo Victor Fasogbon Onyinye Vivian Ojiakor Wusa Makena Emmanuel O. Ikuomola Reuben Samson Dangana Ibe Micheal Usman Ekom Monday Etukudo Augustine Oviosun Swase Dominic Terkimbi Elizabeth Bessy Umoren Angela Mumbua Musyoka Solomon A Mbina Esther Ugo Alum Ibrahim Babangida Abubakar Godson Emeka Anyanwu Patrick Maduabuchi Aja |
| author_facet | Nancy Bonareri Mitaki Ilemobayo Victor Fasogbon Onyinye Vivian Ojiakor Wusa Makena Emmanuel O. Ikuomola Reuben Samson Dangana Ibe Micheal Usman Ekom Monday Etukudo Augustine Oviosun Swase Dominic Terkimbi Elizabeth Bessy Umoren Angela Mumbua Musyoka Solomon A Mbina Esther Ugo Alum Ibrahim Babangida Abubakar Godson Emeka Anyanwu Patrick Maduabuchi Aja |
| author_sort | Nancy Bonareri Mitaki |
| collection | DOAJ |
| description | Background Information: Diabetes is a serious global health issue that is particularly common in East Africa. Lifestyle factors influence the incidence, mortality, and morbidity of diabetes. Medicinal plants have phytochemicals with anti-diabetic properties. Purpose: This systematic review assesses the efficacy, efficiency, safety, and feasibility of phytotherapy in the treatment of diabetes in the East African Community (EAC). Methods: we conducted a comprehensive literature search using PubMed, Scopus, and Web of Science databases. We limited our search to peer-reviewed English articles, preclinical models, and intervention studies reporting the use of medicinal plants in the treatment of diabetes, particularly in EAC. This article follows the Guidelines for Systematic Reviews and Meta-Analyses (PRISMA) 2020. Two reviewers independently performed data collection and quality assessment. We retrieved 465 articles from the database and reviewed eight articles that met the inclusion criteria for this study. Results: we identified eight medicinal plants: Maerua decumbens, Rotheca myricoides (Hochst), Piper capence, Berberis holstii, Polyscias fulva (Hiern) Harms, Lippia javanica, Caesalpina bonducella, and Securinega virosa. We extracted and analyzed information from the literature and showed that seven medicinal plants reduce blood sugar levels and insulin sensitivity through their mechanism of action. Conclusion: The phytochemical properties of these medicinal plants, mainly containing alkaloids, tannins, and flavonoids, may contribute to their hypoglycemic effects. Caesalpinia bonducella seed extract is less effective in controlling high blood sugar. More preclinical studies are needed to investigate the potential of phytotherapy in the management of diabetes in EAC. |
| format | Article |
| id | doaj-art-5c0cdef396a34bfd9ee7173cd3cc3b44 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-5c0cdef396a34bfd9ee7173cd3cc3b442025-02-10T04:35:16ZengElsevierPhytomedicine Plus2667-03132025-02-0151100717A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa communityNancy Bonareri Mitaki0Ilemobayo Victor Fasogbon1Onyinye Vivian Ojiakor2Wusa Makena3Emmanuel O. Ikuomola4Reuben Samson Dangana5Ibe Micheal Usman6Ekom Monday Etukudo7Augustine Oviosun8Swase Dominic Terkimbi9Elizabeth Bessy Umoren10Angela Mumbua Musyoka11Solomon A Mbina12Esther Ugo Alum13Ibrahim Babangida Abubakar14Godson Emeka Anyanwu15Patrick Maduabuchi Aja16Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, Uganda; Corresponding author at: PO BOX 71, Bushenyi, Uganda.Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Publications and Extension, Kampala International University, PO Box 20000, UgandaDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Anatomy, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaDepartment of Biochemistry, Faculty of Biomedical Sciences, Kampala International University, Western Campus, UgandaBackground Information: Diabetes is a serious global health issue that is particularly common in East Africa. Lifestyle factors influence the incidence, mortality, and morbidity of diabetes. Medicinal plants have phytochemicals with anti-diabetic properties. Purpose: This systematic review assesses the efficacy, efficiency, safety, and feasibility of phytotherapy in the treatment of diabetes in the East African Community (EAC). Methods: we conducted a comprehensive literature search using PubMed, Scopus, and Web of Science databases. We limited our search to peer-reviewed English articles, preclinical models, and intervention studies reporting the use of medicinal plants in the treatment of diabetes, particularly in EAC. This article follows the Guidelines for Systematic Reviews and Meta-Analyses (PRISMA) 2020. Two reviewers independently performed data collection and quality assessment. We retrieved 465 articles from the database and reviewed eight articles that met the inclusion criteria for this study. Results: we identified eight medicinal plants: Maerua decumbens, Rotheca myricoides (Hochst), Piper capence, Berberis holstii, Polyscias fulva (Hiern) Harms, Lippia javanica, Caesalpina bonducella, and Securinega virosa. We extracted and analyzed information from the literature and showed that seven medicinal plants reduce blood sugar levels and insulin sensitivity through their mechanism of action. Conclusion: The phytochemical properties of these medicinal plants, mainly containing alkaloids, tannins, and flavonoids, may contribute to their hypoglycemic effects. Caesalpinia bonducella seed extract is less effective in controlling high blood sugar. More preclinical studies are needed to investigate the potential of phytotherapy in the management of diabetes in EAC.http://www.sciencedirect.com/science/article/pii/S266703132400191XDiabetes mellitusMedicinal plantsEast Africa communitySystematic review |
| spellingShingle | Nancy Bonareri Mitaki Ilemobayo Victor Fasogbon Onyinye Vivian Ojiakor Wusa Makena Emmanuel O. Ikuomola Reuben Samson Dangana Ibe Micheal Usman Ekom Monday Etukudo Augustine Oviosun Swase Dominic Terkimbi Elizabeth Bessy Umoren Angela Mumbua Musyoka Solomon A Mbina Esther Ugo Alum Ibrahim Babangida Abubakar Godson Emeka Anyanwu Patrick Maduabuchi Aja A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community Phytomedicine Plus Diabetes mellitus Medicinal plants East Africa community Systematic review |
| title | A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community |
| title_full | A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community |
| title_fullStr | A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community |
| title_full_unstemmed | A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community |
| title_short | A systematic review of plant-based therapy for the management of diabetes mellitus in the East Africa community |
| title_sort | systematic review of plant based therapy for the management of diabetes mellitus in the east africa community |
| topic | Diabetes mellitus Medicinal plants East Africa community Systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S266703132400191X |
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