Functional Dyspepsia and Gastroesophageal Reflux Disease: From Pathogenesis to Current Treatment Strategies
Aim: to present a modern view on the combination of functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) and to evaluate the effectiveness of acotiamide in patients with FD and GERD.Key points. The high frequency of the combination of FD and GERD is caused by common pathogenetic mech...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2024-12-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1168 |
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| author | A. S. Trukhmanov D. E. Rumyantseva |
| author_facet | A. S. Trukhmanov D. E. Rumyantseva |
| author_sort | A. S. Trukhmanov |
| collection | DOAJ |
| description | Aim: to present a modern view on the combination of functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) and to evaluate the effectiveness of acotiamide in patients with FD and GERD.Key points. The high frequency of the combination of FD and GERD is caused by common pathogenetic mechanisms and presents an urgent problem in clinical practice. The concurrent occurrence of these diseases alters the clinical picture, complicates differential diagnostics, and leads to inadequate prescription of drugs. Medical treatment for patients with FD and GERD includes the use of proton pump inhibitors (PPIs) and prokinetics. Currently, acotiamide is recognized as an effective drug that affects the motility of the upper gastrointestinal tract. Acotiamide is an antagonist of muscarinic M1 and M2 receptors and a reversible inhibitor of acetylcholinesterase. The clinical efficacy of this drug has been demonstrated not only in patients with FD but also in those with a combination of FD and GERD.Conclusion. Administration of acotiamide is pathogenetically justified in patients with the combination of GERD and FD. |
| format | Article |
| id | doaj-art-5c31246044d446309329003d6a627358 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-5c31246044d446309329003d6a6273582025-02-10T16:14:40ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732024-12-01345839210.22416/1382-4376-2024-34-5-83-921076Functional Dyspepsia and Gastroesophageal Reflux Disease: From Pathogenesis to Current Treatment StrategiesA. S. Trukhmanov0D. E. Rumyantseva1I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Aim: to present a modern view on the combination of functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) and to evaluate the effectiveness of acotiamide in patients with FD and GERD.Key points. The high frequency of the combination of FD and GERD is caused by common pathogenetic mechanisms and presents an urgent problem in clinical practice. The concurrent occurrence of these diseases alters the clinical picture, complicates differential diagnostics, and leads to inadequate prescription of drugs. Medical treatment for patients with FD and GERD includes the use of proton pump inhibitors (PPIs) and prokinetics. Currently, acotiamide is recognized as an effective drug that affects the motility of the upper gastrointestinal tract. Acotiamide is an antagonist of muscarinic M1 and M2 receptors and a reversible inhibitor of acetylcholinesterase. The clinical efficacy of this drug has been demonstrated not only in patients with FD but also in those with a combination of FD and GERD.Conclusion. Administration of acotiamide is pathogenetically justified in patients with the combination of GERD and FD.https://www.gastro-j.ru/jour/article/view/1168functional dyspepsiagastroesophageal reflux diseaseprokineticsacotiamide |
| spellingShingle | A. S. Trukhmanov D. E. Rumyantseva Functional Dyspepsia and Gastroesophageal Reflux Disease: From Pathogenesis to Current Treatment Strategies Российский журнал гастроэнтерологии, гепатологии, колопроктологии functional dyspepsia gastroesophageal reflux disease prokinetics acotiamide |
| title | Functional Dyspepsia and Gastroesophageal Reflux Disease: From Pathogenesis to Current Treatment Strategies |
| title_full | Functional Dyspepsia and Gastroesophageal Reflux Disease: From Pathogenesis to Current Treatment Strategies |
| title_fullStr | Functional Dyspepsia and Gastroesophageal Reflux Disease: From Pathogenesis to Current Treatment Strategies |
| title_full_unstemmed | Functional Dyspepsia and Gastroesophageal Reflux Disease: From Pathogenesis to Current Treatment Strategies |
| title_short | Functional Dyspepsia and Gastroesophageal Reflux Disease: From Pathogenesis to Current Treatment Strategies |
| title_sort | functional dyspepsia and gastroesophageal reflux disease from pathogenesis to current treatment strategies |
| topic | functional dyspepsia gastroesophageal reflux disease prokinetics acotiamide |
| url | https://www.gastro-j.ru/jour/article/view/1168 |
| work_keys_str_mv | AT astrukhmanov functionaldyspepsiaandgastroesophagealrefluxdiseasefrompathogenesistocurrenttreatmentstrategies AT derumyantseva functionaldyspepsiaandgastroesophagealrefluxdiseasefrompathogenesistocurrenttreatmentstrategies |