An exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic Neuropathy
Abstract Electrical stimulation (ES) may be effective for intractable retinal or optic nerve diseases. We studied frequent transcutaneous ES in a single-center, single-arm prospective study in patients with Leber hereditary optic neuropathy (LHON) who carry the mitochondrial (mt) 11778 G > A muta...
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Nature Portfolio
2025-02-01
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| author | Fumio Takano Kaori Ueda Takuji Kurimoto Mina Arai Takayuki Nagai Yuko Yamada-Nakanishi Makoto Nakamura |
| author_facet | Fumio Takano Kaori Ueda Takuji Kurimoto Mina Arai Takayuki Nagai Yuko Yamada-Nakanishi Makoto Nakamura |
| author_sort | Fumio Takano |
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| description | Abstract Electrical stimulation (ES) may be effective for intractable retinal or optic nerve diseases. We studied frequent transcutaneous ES in a single-center, single-arm prospective study in patients with Leber hereditary optic neuropathy (LHON) who carry the mitochondrial (mt) 11778 G > A mutation. A 30-min ES was applied to either eye every other day for 12 weeks. The primary outcome was the difference in the logarithm of the minimum angle of resolution (LogMAR) at baseline and 1 week after completion of ES treatment. The secondary outcomes included changes in visual field; LogMAR; critical flicker frequency; and inner retinal thickness. Safety endpoints included the corneal endothelial cell density and complications during ES. Fourteen patients participated in the study; four dropped out. The median (interquartile range) LogMAR values before stimulation and 1, 4, and 8 weeks after ES were 1.60 (1.45–1.80), 1.70 (1.35–1.80), 1.60 (1.43–1.73), and 1.50 (1.43–1.73), respectively, indicating no significant improvement (primary outcome: Wilcoxon’s signed rank test, p = 1.000, secondary outcome: Friedman test, p = 0.229). There were no improvements in any secondary efficacy endpoints and no complications. In conclusion, frequent transcutaneous ES did not improve visual acuity in patients with LHON carrying the mt11778 G > A mutation. |
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| institution | Kabale University |
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| language | English |
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| spelling | doaj-art-5d358aaf9bb040eaae7ca9c74ecc65232025-02-09T12:33:05ZengNature PortfolioScientific Reports2045-23222025-02-0115111210.1038/s41598-025-89076-zAn exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic NeuropathyFumio Takano0Kaori Ueda1Takuji Kurimoto2Mina Arai3Takayuki Nagai4Yuko Yamada-Nakanishi5Makoto Nakamura6Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of MedicineDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of MedicineKurimoto Eye ClinicDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of MedicineDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of MedicineDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of MedicineDivision of Ophthalmology, Department of Surgery, Kobe University Graduate School of MedicineAbstract Electrical stimulation (ES) may be effective for intractable retinal or optic nerve diseases. We studied frequent transcutaneous ES in a single-center, single-arm prospective study in patients with Leber hereditary optic neuropathy (LHON) who carry the mitochondrial (mt) 11778 G > A mutation. A 30-min ES was applied to either eye every other day for 12 weeks. The primary outcome was the difference in the logarithm of the minimum angle of resolution (LogMAR) at baseline and 1 week after completion of ES treatment. The secondary outcomes included changes in visual field; LogMAR; critical flicker frequency; and inner retinal thickness. Safety endpoints included the corneal endothelial cell density and complications during ES. Fourteen patients participated in the study; four dropped out. The median (interquartile range) LogMAR values before stimulation and 1, 4, and 8 weeks after ES were 1.60 (1.45–1.80), 1.70 (1.35–1.80), 1.60 (1.43–1.73), and 1.50 (1.43–1.73), respectively, indicating no significant improvement (primary outcome: Wilcoxon’s signed rank test, p = 1.000, secondary outcome: Friedman test, p = 0.229). There were no improvements in any secondary efficacy endpoints and no complications. In conclusion, frequent transcutaneous ES did not improve visual acuity in patients with LHON carrying the mt11778 G > A mutation.https://doi.org/10.1038/s41598-025-89076-zElectrical stimulationLeber Hereditary Optic NeuropathyMitochondrial diseaseProspective studyVisual field |
| spellingShingle | Fumio Takano Kaori Ueda Takuji Kurimoto Mina Arai Takayuki Nagai Yuko Yamada-Nakanishi Makoto Nakamura An exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic Neuropathy Scientific Reports Electrical stimulation Leber Hereditary Optic Neuropathy Mitochondrial disease Prospective study Visual field |
| title | An exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic Neuropathy |
| title_full | An exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic Neuropathy |
| title_fullStr | An exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic Neuropathy |
| title_full_unstemmed | An exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic Neuropathy |
| title_short | An exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic Neuropathy |
| title_sort | exploratory study to evaluate efficacy and safety of frequent transcutaneous electrical stimulation for leber hereditary optic neuropathy |
| topic | Electrical stimulation Leber Hereditary Optic Neuropathy Mitochondrial disease Prospective study Visual field |
| url | https://doi.org/10.1038/s41598-025-89076-z |
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