A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients
Background and Objectives: Type-2 diabetes mellitus (T2DM) is a systemic disease which have higher incidence of gingivitis and periodontitis. Pomegranate peel has higher content of phenolic compounds with potent anti-inflammatory, antioxidant and antibacterial activity. The aim is to evaluate the e...
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College Of Dentistry Hawler Medical University
2020-06-01
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| Series: | Erbil Dental Journal |
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| Online Access: | https://edj.hmu.edu.krd/index.php/journal/article/view/76 |
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| author | Shayma Ghazi Dilyar Ahmed Baban Saif Monem Aziz |
| author_facet | Shayma Ghazi Dilyar Ahmed Baban Saif Monem Aziz |
| author_sort | Shayma Ghazi |
| collection | DOAJ |
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Background and Objectives: Type-2 diabetes mellitus (T2DM) is a systemic disease which have higher incidence of gingivitis and periodontitis. Pomegranate peel has higher content of phenolic compounds with potent anti-inflammatory, antioxidant and antibacterial activity. The aim is to evaluate the efficacy of pomegranate peel extract on the clinical and biochemical measures of (IL-1β) and the enzyme (AST) in saliva of (T2DM) patients suffering from gingivitis in comparison with chlorhexidine.
Patients and Methods: A randomized controlled clinical trial on 45 (T2DM) patients, both sexes with moderate gingivitis, age 40-55 years, (Hb1Ac) < 7%. They were randomly assigned to 3 groups undergo scaling and polishing, (15) for each group, group 1 used chlorhexidine mouthwash (0.12%), group 2 used pomegranate peel extract (6.25%) and group 3 pomegranate peel extract (12.5%). Before and after 14 days, PI, GI, BOP, salivary IL-1β and AST were evaluated.
Results: All the results for both biochemical and clinical parameters in the three groups showed significant reduction after 14 days of treatment except for the salivary IL-1β in group 1. No significant difference between group1 and group 2 except for PLI and group1 and group 3 except for IL-1β, while significant differences between group 2 and 3 after 14days of treatment except for the salivary AST, with no side effects associated with the use of pomegranate peel extract as a mouthwash at both concentrations.
Conclusion: pomegranate peel extract could be considered more effective in treating gingivitis especially at the high concentration with no considerable side effects comparing to chlorhexidine.
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| format | Article |
| id | doaj-art-5dc1e36b33a04a1eb9514957a7bd0380 |
| institution | Kabale University |
| issn | 2523-6172 2616-4795 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | College Of Dentistry Hawler Medical University |
| record_format | Article |
| series | Erbil Dental Journal |
| spelling | doaj-art-5dc1e36b33a04a1eb9514957a7bd03802025-02-10T20:48:46ZengCollege Of Dentistry Hawler Medical UniversityErbil Dental Journal2523-61722616-47952020-06-0131A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patientsShayma Ghazi0Dilyar Ahmed Baban1Saif Monem Aziz2Oral and Maxillofacial Surgery Department, College of Dentistry, Hawler Medical UniversityPeriodontics Department, College of Dentistry, Hawler Medical UniversityOral and Maxillofacial surgery Department, College of Dentistry, Hawler Medical University Background and Objectives: Type-2 diabetes mellitus (T2DM) is a systemic disease which have higher incidence of gingivitis and periodontitis. Pomegranate peel has higher content of phenolic compounds with potent anti-inflammatory, antioxidant and antibacterial activity. The aim is to evaluate the efficacy of pomegranate peel extract on the clinical and biochemical measures of (IL-1β) and the enzyme (AST) in saliva of (T2DM) patients suffering from gingivitis in comparison with chlorhexidine. Patients and Methods: A randomized controlled clinical trial on 45 (T2DM) patients, both sexes with moderate gingivitis, age 40-55 years, (Hb1Ac) < 7%. They were randomly assigned to 3 groups undergo scaling and polishing, (15) for each group, group 1 used chlorhexidine mouthwash (0.12%), group 2 used pomegranate peel extract (6.25%) and group 3 pomegranate peel extract (12.5%). Before and after 14 days, PI, GI, BOP, salivary IL-1β and AST were evaluated. Results: All the results for both biochemical and clinical parameters in the three groups showed significant reduction after 14 days of treatment except for the salivary IL-1β in group 1. No significant difference between group1 and group 2 except for PLI and group1 and group 3 except for IL-1β, while significant differences between group 2 and 3 after 14days of treatment except for the salivary AST, with no side effects associated with the use of pomegranate peel extract as a mouthwash at both concentrations. Conclusion: pomegranate peel extract could be considered more effective in treating gingivitis especially at the high concentration with no considerable side effects comparing to chlorhexidine. https://edj.hmu.edu.krd/index.php/journal/article/view/76gingivitispomegranate peelchlorhexidine. |
| spellingShingle | Shayma Ghazi Dilyar Ahmed Baban Saif Monem Aziz A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients Erbil Dental Journal gingivitis pomegranate peel chlorhexidine. |
| title | A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients |
| title_full | A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients |
| title_fullStr | A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients |
| title_full_unstemmed | A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients |
| title_short | A clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients |
| title_sort | clinical trial evaluates the effect of pomegranate extract as a mouth wash for gingivitis in type 2 diabetic patients |
| topic | gingivitis pomegranate peel chlorhexidine. |
| url | https://edj.hmu.edu.krd/index.php/journal/article/view/76 |
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