Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage.
<h4>Purpose</h4>To determine the impact of severity of age-related macular degeneration (AMD) on subjective treatment response in patients treated for dry eye disease.<h4>Methods</h4>A total of 203 eyes diagnosed with evaporative dry eye disease (DED) due to meibomian gland d...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0318733 |
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| author | Nehal Nailesh Mehta Ines D Nagel Akshay Agnihotri Anna Heinke Lingyun Cheng Dirk-Uwe Bartsch William R Freeman Maria-Laura Gomez |
| author_facet | Nehal Nailesh Mehta Ines D Nagel Akshay Agnihotri Anna Heinke Lingyun Cheng Dirk-Uwe Bartsch William R Freeman Maria-Laura Gomez |
| author_sort | Nehal Nailesh Mehta |
| collection | DOAJ |
| description | <h4>Purpose</h4>To determine the impact of severity of age-related macular degeneration (AMD) on subjective treatment response in patients treated for dry eye disease.<h4>Methods</h4>A total of 203 eyes diagnosed with evaporative dry eye disease (DED) due to meibomian gland dysfunction were treated using the LipiFlow or MiBoFlo systems. From this cohort, 40 eyes with stable dry AMD (early, intermediate, or late stages) were included. Each participant completed the Ocular Surface Disease Index (OSDI) and Standard Patient Evaluation of Eye Dryness Questionnaire (SPEED) before treatment and at a 6-month follow-up. Changes in questionnaire scores were analyzed using one-way analysis of variance (ANOVA) to assess differences between AMD severity groups.<h4>Results</h4>Improvement in SPEED and OSDI scores, including vision related OSDI scores were observed across all AMD stages, with no significant differences between groups (p<0.05).<h4>Conclusion</h4>Managing DED improved quality of life (QOL) in patients with AMD, regardless of retinal disease severity. This highlights the importance of treating coexisting ocular surface conditions to enhance patient outcomes, even in the presence of significant maculopathy. |
| format | Article |
| id | doaj-art-5e60af2ac04e4eb8b6b4ccfaba7757a6 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-5e60af2ac04e4eb8b6b4ccfaba7757a62025-02-12T05:30:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01202e031873310.1371/journal.pone.0318733Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage.Nehal Nailesh MehtaInes D NagelAkshay AgnihotriAnna HeinkeLingyun ChengDirk-Uwe BartschWilliam R FreemanMaria-Laura Gomez<h4>Purpose</h4>To determine the impact of severity of age-related macular degeneration (AMD) on subjective treatment response in patients treated for dry eye disease.<h4>Methods</h4>A total of 203 eyes diagnosed with evaporative dry eye disease (DED) due to meibomian gland dysfunction were treated using the LipiFlow or MiBoFlo systems. From this cohort, 40 eyes with stable dry AMD (early, intermediate, or late stages) were included. Each participant completed the Ocular Surface Disease Index (OSDI) and Standard Patient Evaluation of Eye Dryness Questionnaire (SPEED) before treatment and at a 6-month follow-up. Changes in questionnaire scores were analyzed using one-way analysis of variance (ANOVA) to assess differences between AMD severity groups.<h4>Results</h4>Improvement in SPEED and OSDI scores, including vision related OSDI scores were observed across all AMD stages, with no significant differences between groups (p<0.05).<h4>Conclusion</h4>Managing DED improved quality of life (QOL) in patients with AMD, regardless of retinal disease severity. This highlights the importance of treating coexisting ocular surface conditions to enhance patient outcomes, even in the presence of significant maculopathy.https://doi.org/10.1371/journal.pone.0318733 |
| spellingShingle | Nehal Nailesh Mehta Ines D Nagel Akshay Agnihotri Anna Heinke Lingyun Cheng Dirk-Uwe Bartsch William R Freeman Maria-Laura Gomez Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage. PLoS ONE |
| title | Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage. |
| title_full | Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage. |
| title_fullStr | Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage. |
| title_full_unstemmed | Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage. |
| title_short | Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage. |
| title_sort | dry eye disease treatment improves subjective quality of life responses in patients with amd independent of disease stage |
| url | https://doi.org/10.1371/journal.pone.0318733 |
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