Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial
Abstract In addition to topical non-steroidal anti-inflammatory drugs that are used in hand osteoarthritis, there are other drugs that can reduce pain in osteoarthritis, such as topical cetylated fatty acids. Previous studies have reported that topical CFAs are effective in all knee OA patients, wit...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88202-1 |
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| author | Sitthiphong Suwannaphisit Nitiphoom Sinnathakorn Pormes Suwanno Warangkana Fongsri Boonsin Tangtrakulwanich |
| author_facet | Sitthiphong Suwannaphisit Nitiphoom Sinnathakorn Pormes Suwanno Warangkana Fongsri Boonsin Tangtrakulwanich |
| author_sort | Sitthiphong Suwannaphisit |
| collection | DOAJ |
| description | Abstract In addition to topical non-steroidal anti-inflammatory drugs that are used in hand osteoarthritis, there are other drugs that can reduce pain in osteoarthritis, such as topical cetylated fatty acids. Previous studies have reported that topical CFAs are effective in all knee OA patients, with slightly higher evidence for those with advanced disease. The mechanism of pain in OA knee and OA hand is similar. Furthermore, there are no previous studies on CFAs in OA hand. Patients fulfilling the American College of Rheumatology criteria for hand OA participated in this randomized, double-blind, placebo-controlled study. Eligible patients were over 40 years of age, had at least one tender joint, and had a joint pain visual analog score of 30–60 mm. Patients received topical CFA (n = 36) or placebo (n = 36) twice daily for six weeks. The primary outcome was the Functional Index for Hand Osteoarthritis (FIHOA) at 2, 4, and 6 weeks. The secondary outcome measures included the Visual Analog Score (VAS), Patient Global Assessment (PGA), and skin irritation at 2, 4, and 6 weeks. At baseline, no statistically significant differences were observed among the assessment parameters. Upon concluding the 6-week study period, it was evident that patients in the CFA group exhibited a notably lower mean pain score compared to those in the placebo group (2.2 ± 1.9 vs. 3.2 ± 2.2, P < 0.05) and achieved superior PGA scores (2.1 ± 1.7 vs. 3.1 ± 2.2, P < 0.05). However, no significant disparity was detected in terms of FIHOA between the two groups. Additionally, adverse reactions were reported by two patients in the placebo group, whereas no such reports were documented in the CFA group. Topical CFAs demonstrate efficacy in alleviating pain and enhancing patient global satisfaction in the treatment of hand osteoarthritis. However, a more extended follow-up period is imperative to ascertain whether disparities exist in the safety profile and functional outcomes between topical CFAs and a placebo. |
| format | Article |
| id | doaj-art-5eb07215e4f0450f83b7f341401bdb96 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-5eb07215e4f0450f83b7f341401bdb962025-02-09T12:28:24ZengNature PortfolioScientific Reports2045-23222025-02-011511910.1038/s41598-025-88202-1Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trialSitthiphong Suwannaphisit0Nitiphoom Sinnathakorn1Pormes Suwanno2Warangkana Fongsri3Boonsin Tangtrakulwanich4Department of Orthopaedics, Faculty of Medicine Vajira Hospital, Navamindradhiraj UniversityDepartment of Orthopaedics, School of Medicine, University of PhayaoDepartment of Orthopaedics, Faculty of Medicine, Prince of Songkla UniversityDepartment of Orthopaedics, Faculty of Medicine, Prince of Songkla UniversityDepartment of Orthopaedics, Faculty of Medicine, Prince of Songkla UniversityAbstract In addition to topical non-steroidal anti-inflammatory drugs that are used in hand osteoarthritis, there are other drugs that can reduce pain in osteoarthritis, such as topical cetylated fatty acids. Previous studies have reported that topical CFAs are effective in all knee OA patients, with slightly higher evidence for those with advanced disease. The mechanism of pain in OA knee and OA hand is similar. Furthermore, there are no previous studies on CFAs in OA hand. Patients fulfilling the American College of Rheumatology criteria for hand OA participated in this randomized, double-blind, placebo-controlled study. Eligible patients were over 40 years of age, had at least one tender joint, and had a joint pain visual analog score of 30–60 mm. Patients received topical CFA (n = 36) or placebo (n = 36) twice daily for six weeks. The primary outcome was the Functional Index for Hand Osteoarthritis (FIHOA) at 2, 4, and 6 weeks. The secondary outcome measures included the Visual Analog Score (VAS), Patient Global Assessment (PGA), and skin irritation at 2, 4, and 6 weeks. At baseline, no statistically significant differences were observed among the assessment parameters. Upon concluding the 6-week study period, it was evident that patients in the CFA group exhibited a notably lower mean pain score compared to those in the placebo group (2.2 ± 1.9 vs. 3.2 ± 2.2, P < 0.05) and achieved superior PGA scores (2.1 ± 1.7 vs. 3.1 ± 2.2, P < 0.05). However, no significant disparity was detected in terms of FIHOA between the two groups. Additionally, adverse reactions were reported by two patients in the placebo group, whereas no such reports were documented in the CFA group. Topical CFAs demonstrate efficacy in alleviating pain and enhancing patient global satisfaction in the treatment of hand osteoarthritis. However, a more extended follow-up period is imperative to ascertain whether disparities exist in the safety profile and functional outcomes between topical CFAs and a placebo.https://doi.org/10.1038/s41598-025-88202-1Cetylated fatty acidCFAHand osteoarthritisHand OA |
| spellingShingle | Sitthiphong Suwannaphisit Nitiphoom Sinnathakorn Pormes Suwanno Warangkana Fongsri Boonsin Tangtrakulwanich Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial Scientific Reports Cetylated fatty acid CFA Hand osteoarthritis Hand OA |
| title | Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial |
| title_full | Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial |
| title_fullStr | Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial |
| title_full_unstemmed | Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial |
| title_short | Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial |
| title_sort | impact of topical cetylated fatty acid cream on hand osteoarthritis a randomized double blind clinical trial |
| topic | Cetylated fatty acid CFA Hand osteoarthritis Hand OA |
| url | https://doi.org/10.1038/s41598-025-88202-1 |
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